Calcitonin stimulates gluconeogenesis in fasted rats.

Yamaguchi, Masayoshi

doi:10.1507/endocrj1954.28.51

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…The Pck2 and G6pc3 data also partially support this indication (Figure S5B, C). This finding is, of course, not entirely surprising since CT alone can induce hepatic gluconeogenesis [45]–[47]. The important point to be made here is that neither agent alone is the magic bullet.…”

Section: Discussionmentioning

confidence: 69%

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis

et al. 2013

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IntroductionPrevious work reported the anti-arthritic synergy afforded by combining calcitonin (CT) and glucocorticoids (GC). Here we focus on the pairing of elcatonin (eCT) and dexamethasone (Dex), querying whether: i) this was a class-effect action; ii) mechanistic insights could be unveiled; iii) the synergy affected canonical GC adverse effects.MethodsUsing the rat collagen-induced arthritis model, different combinations of eCT and Dex, were administered from disease onset to peak (day 11 to 18). Macroscopic disease score was monitored throughout, with biochemical and histological analyses conducted on plasma and tissues at day 18. The effect on acute hyperglycaemia and liver enzyme message were also assessed.ResultsWhilst eCT alone was inactive, it synergised at 1 µg/kg with low doses of Dex (7.5 or 15 µg/kg) to yield an anti-arthritic efficacy equivalent to a 4- to 7-fold higher Dex dose. Mechanistically, the anti-arthritic synergy corresponded to a marked attenuation in RA-relevant analytes. CXCL5 expression, in both plasma and joint, was markedly inhibited by the co-therapy. Finally, co-administration of eCT did not exacerbate metrics of GC adverse effects, and rescued some of them.ConclusionsWe present evidence of a class-effect action for the anti-arthritic synergy of CT/GC combination, underpinned by the powerful inhibition of joint destruction markers. Furthermore, we identify CXCL5 as a marker for the combination therapy with potential diagnostic and prognostic utility. Substantial GC dose reduction, together with the absence of exacerbated adverse effects, indicated a significant clinical potential for this co-therapy in RA and beyond.

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Section: Discussionmentioning

confidence: 69%

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis

et al. 2013

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“…The results of our previous investigations allow consider that it is mediated both due to the inhibitory effect of CT on insulin secretion [11,12], the decreasing of glucose consumption by peripheral tissues [13] and due to the intensification of glycogenolysis process [14,15]. These changes result in hyperglycemia, insulin resistance, and impaired glucose tolerance.…”

Section: Methodsmentioning

confidence: 95%

Calcitonin and parathyrin are antagonists concerning to the regulation of glucose metabolism

Moisa¹

2018

Integr Food Nutr Metab

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Materials about calcium-regulating hormones (calcitonin and parathyrin) effect on carbohydrate regulation are represented. It is showed calcitonin hyperglycemic effect, its contra-insulin effect to insulin. It is ascertained the impairment of glucose metabolism under calcitonin-hyperglycemia, insulin resistance and glucose intolerance. It is established the opposite to calcitonin action of parathyrin on glucose metabolism: decreasing the glucose level and increasing glucose tolerance. It is concluded that calcitonin and parathyrin are antagonists not only concerning to the regulation of calcium metabolism, but and glucose.

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“…Recently it has been reported that CT stimulates gluconeogenesis from alanine, lactate and pyruvate in fasted rats (Yamaguchi 1981b), and from alanine and glutamine in isolated rat hepatocytes (Yamaguchi and Williamson 1983). However, the mechanism of CT actions remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…This effect of CT is not dependent on the release of epinephrine from the adrenal glands (Yamaguchi 1980) or glucagon from the pancreas of rats (Yamaguchi 1981a). More recently it has been shown that CT stimulates glucose production from alanine in the liver of rats (Yamaguchi 1981b) and in isolated rat hepatocytes (Yamaguchi and Williamson 1982).…”

Section: Introductionmentioning

confidence: 90%

Calcitonin Increases Alanine Aminotransferase Activity Related to Calcium in the Hepatic Mitochondria of Rats

Yamaguchi¹,

Momose²

1984

Horm Metab Res

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The effect of calcitonin (CT) on alanine aminotransferase activity and calcium content in the hepatic mitochondria of intact rats was investigated. A single subcutaneous administration of CT (synthetic [Asu1,7] eel calcitonin; 80 MRC mU/100 g body weight) produced a significant increase in alanine aminotransferase activity and a corresponding elevation of calcium content. Those increases were also observed with the lowest dose of CT (20 MRC mU/100 g). The mitochondrial calcium depletion by 10 mM EGTA treatment produced a remarkable reduction in alanine aminotransferase activity increased by CT, although EGTA treatment did not alter basal enzyme activity. Addition of calcium ion (1-10(3) microM) into the EGTA-treated mitochondria, however, produced a significant increase in alanine aminotransferase activity. The enzyme activity increased by CT was not inhibited by the presence of calmodulin inhibitor, W-7 (1-10(3) microM). These results suggest that the mitochondrial calcium increased by CT administration directly activates alanine aminotransferase in the hepatic mitochondria of rats.

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Calcitonin stimulates gluconeogenesis in fasted rats.

Cited by 15 publications

References 13 publications

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis

Calcitonin and parathyrin are antagonists concerning to the regulation of glucose metabolism

Calcitonin Increases Alanine Aminotransferase Activity Related to Calcium in the Hepatic Mitochondria of Rats

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