2015
DOI: 10.1093/ckj/sfv011
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Calcitonin, the forgotten hormone: does it deserve to be forgotten?

Abstract: Calcitonin is a 32 amino acid hormone secreted by the C-cells of the thyroid gland. Calcitonin has been preserved during the transition from ocean-based life to land dwellers and is phylogenetically older than parathyroid hormone. Calcitonin secretion is stimulated by increases in the serum calcium concentration and calcitonin protects against the development of hypercalcemia. Calcitonin is also stimulated by gastrointestinal hormones such as gastrin. This has led to the unproven hypothesis that postprandial c… Show more

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Cited by 109 publications
(77 citation statements)
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“…Elcatonin, a synthetic eel calcitonin, has been shown to inhibit gastric and duodenal ulcers . Calcitonin receptor‐like receptors have been localized to the human GI tract, and the peptide hormone gastrin, responsible for the secretion of gastric acid by parietal cells, significantly upregulates CT secretion ,,. A similar effect has been found for several other gastrointestinal hormones, as well .…”
Section: Physiological Rolessupporting
confidence: 58%
See 1 more Smart Citation
“…Elcatonin, a synthetic eel calcitonin, has been shown to inhibit gastric and duodenal ulcers . Calcitonin receptor‐like receptors have been localized to the human GI tract, and the peptide hormone gastrin, responsible for the secretion of gastric acid by parietal cells, significantly upregulates CT secretion ,,. A similar effect has been found for several other gastrointestinal hormones, as well .…”
Section: Physiological Rolessupporting
confidence: 58%
“…Treatment with sCT rescued mineral loss and time to return to baseline . As such, a heightened physiological role for CT during pregnancy and lactation when the mother is under elevated demand for calcium, has been proposed ,,…”
Section: Physiological Rolesmentioning
confidence: 96%
“…Others have observed low plasma calcitonin values in normocalcemic healthy cats (maximum, 3.2 pg/mL) . Low circulating calcitonin concentrations (<10 pg/mL) are considered normal in healthy humans, but up to 30% of human CKD patients have increased plasma calcitonin concentrations in the absence of hypercalcemia . This secondary hypercalcitoninemia could either be explained by decreased degradation, as calcitonin is predominantly degraded by the kidneys, or more likely, by increased secretion, as C‐cell hyperplasia is commonly associated with hypercalcitoninemia in humans with CKD .…”
Section: Discussionmentioning
confidence: 99%
“…The foremost function of calcitonin is thought to be lowering of blood calcium concentration, and so to protect against hypercalcemia . However, a calcitonin response appears to be absent in the majority of cats with azotemic CKD as only a 3rd showed an increase in plasma calcitonin in response to naturally occurring ionized hypercalcemia.…”
Section: Discussionmentioning
confidence: 99%
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