Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts

Lee, Ting-Wei; Kao, Yu Hsun; Lee, Ting-I; Chang, Chun-Jen; Lien, Gi Shih; Chen, Yi Jen

doi:10.1016/j.ijcard.2014.02.041

Cited by 50 publications

(28 citation statements)

References 30 publications

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“…The underlying mechanisms were poorly understood, although several studies demonstrated that the profibrotic effect of HMGB 1 might be due to binding to its receptors such as RAGE, TLR4, and TLR2 [18, 30]. In line with our investigation, several reports indicated that RAGE, NADPH oxidase, and fibrosis were enhanced in diabetic hearts [31, 32]. In this investigation, TLR4 expression and ROS production were upregulated in DM mice compared to normal mice.…”

Section: Discussionsupporting

confidence: 86%

Reduced HMGB 1‐Mediated Pathway and Oxidative Stress in Resveratrol‐Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Sheng

Xie

et al. 2016

Oxidative Medicine and Cellular Longevity

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Myocardial fibrosis and inflammation are intricately linked in diabetic cardiomyopathy (DCM), and resveratrol has been shown to attenuate oxidative stress, inflammation, and fibrosis in several cell types or animal models. High mobility group box 1 (HMGB 1), a proinflammatory cytokine, has been reported to regulate fibrosis and inflammation in various organs. Then the present study aimed to reveal the expression of HMGB 1-mediated signaling pathway and oxidative stress in resveratrol-treated diabetic mice. The significant increase in serum HMGB 1 concentration in diabetic mice was attenuated by treatment with resveratrol. Similarly, western blot analysis revealed a significant increase of HMGB 1 protein in monocytes and heart tissues of diabetic mice, and resveratrol partly normalized the changes. In addition, resveratrol abrogated the increased expression of HMGB 1-mediated signaling pathway, oxidative stress, fibrosis, and inflammation in diabetic hearts. In conclusion, inhibition of HMGB 1-mediated signaling pathway and oxidative stress may contribute to resveratrol-induced anti-inflammatory and antifibrotic effects in DCM.

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Section: Discussionsupporting

confidence: 86%

Reduced HMGB 1‐Mediated Pathway and Oxidative Stress in Resveratrol‐Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Sheng

Xie

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Treatment of the diabetic mice with calcitriol resulted in decreased expression of myocardial RAGE, TNF-α, p22 phox , AT1R, TGF-β1, p-SMAD2/3 and p-ERK signaling, and procollagen I. These results suggest the beneficial role of vitamin D in decreasing the effect of diabetes on myocardial RAGE and fibrosis by modulating the AT1R, and further signify the anti-inflammatory, anti-oxidative, and cardioprotective effects of vitamin D [48] (Figure 2). …”

Section: Cardiac Diseasesmentioning

confidence: 96%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

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“…RAGE levels are enhanced in a number of diseases states such as cardiovascular disease, Alzheimer's diseases (AD), diabetes, osteoarthritis, and various tumours [77,78]. Many of these diseases are associated with RAGE-induced inflammation so it is significant that Vitamin D may act to modulate RAGE expression [79].…”

Section: Vitamin D and Redox Signallingmentioning

confidence: 99%