Calcitriol Sensitizes Cervical Cancer Cells To Irradiation By Regulating Autophagy And Apoptosis

Cheng, Guanghui; Liu, B.; Yu, Xiaofeng

doi:10.1016/j.ijrobp.2020.07.1601

Cited by 1 publication

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“…AMBRA1-associated autophagy promotes the transition from hyper-radiosensitivity to induced radio-resistance in A549 and H460 human lung adenocarcinoma cell lines ( 84 ). Calcitriol, an active metabolite of vitamin D, enhances the sensitivity to irradiation in SiHa and CaSki cervical cancer cells by promoting AMBRA1 degradation ( 85 ). Therefore, the combination of AMBRA1 suppression and chemoradiotherapy may achieve a favorable outcome.…”

Section: Ambra1—a Potential Target For Anticancer Therapymentioning

confidence: 99%

AMBRA1 and its role as a target for anticancer therapy

Yuan

et al. 2022

Front. Oncol.

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The activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1) is an intrinsically disordered protein that regulates the survival and death of cancer cells by modulating autophagy. Although the roles of autophagy in cancer are controversial and context-dependent, inhibition of autophagy under some circumstances can be a useful strategy for cancer therapy. As AMBRA1 is a pivotal autophagy-associated protein, targeting AMBRA1 similarly may be an underlying strategy for cancer therapy. Emerging evidence indicates that AMBRA1 can also inhibit cancer formation, maintenance, and progression by regulating c-MYC and cyclins, which are frequently deregulated in human cancer cells. Therefore, AMBRA1 is at the crossroad of autophagy, tumorigenesis, proliferation, and cell cycle. In this review, we focus on discussing the mechanisms of AMBRA1 in autophagy, mitophagy, and apoptosis, and particularly the roles of AMBRA1 in tumorigenesis and targeted therapy.

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Section: Ambra1—a Potential Target For Anticancer Therapymentioning

confidence: 99%

AMBRA1 and its role as a target for anticancer therapy

Yuan

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Calcitriol Sensitizes Cervical Cancer Cells To Irradiation By Regulating Autophagy And Apoptosis

Cited by 1 publication

References 0 publications

AMBRA1 and its role as a target for anticancer therapy

AMBRA1 and its role as a target for anticancer therapy

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