Calcium absorption is not increased by caseinophosphopeptides

Abstract

The differences in calcium absorption are unlikely to have any biological significance. CPPs are unsuitable as candidate ingredients for functional foods that are designed to deliver improved calcium nutrition.

Caseinphosphopeptide-induced calcium uptake in human intestinal cell lines HT-29 and Caco2 is correlated to cellular differentiation☆

“…It is worth remembering that recent clinical studies reported a lack of effects by CPPs on calcium absorption and balance [18,19], but these data are not conclusive, since a lot of factors, difficult to analyze and standardize, such as the presence of fibers in the meal, the different pH and the osmolality of the gastrointestinal tracts, can affect the calcium-CPP aggregates, leading to the loss of their biological action. Further studies are planned, first of all at the molecular level, using in vitro established cellular models under controlled experimental conditions [56] which can reproduce the physiology and functionality of the human gut and successively at the animal or human in vivo level, to completely clarify this important issue.…”

“…The CPP-mediated enhanced Ca 2+ absorption observed in the rat ileum sacs or ligated segments [3][4][5][6][7][8][9][10][11] demonstrated a positive role by CPPs on calcium bioavailability in animals, suggesting that CPPs may act as functional foods. This hypothesis had some support in animal studies, whereas investigations on humans provided conflicting results [12][13][14][15][16][17][18]. In parallel with these studies in animals and humans, numerous works studied the aggregative properties of CPPs, starting from the notion that casein in milk is present as micelles with calcium and phosphate salts, and demonstrated that this supramolecular structure may be relevant for CPPs to exert a functional role.…”

Milk intelligence: Mining milk for bioactive substances associated with human health

“…Indeed, administration of 1 g of CPPs did not affect calcium metabolism acutely in nine postmenopausal women following adminstration of either CPP-enriched milk or CPP-enriched fermented milk (Narva, Karkkainen, Poussa, Lamberg-Allardt, & Korpela, 2003). While the effect of high doses of 2 well-defined CPP-enriched preparations on 15 volunteers consuming calcium lactate drinks did indicate a positive effect of the CPPs on calcium absorption, it was concluded that the differences in calcium absorption were unlikely to have any biological significance (Teucher et al, 2006). On the other hand, CPPs have been shown to have anticariogenic properties and to prevent enamel demineralisation (Aimutis, 2004;Grenby, Andrews, Mistry, & Williams, 2001).…”

Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status

“…The effect of CPP on mineral absorption in humans has revealed conflicting results (Ait-Oukhatar et al, 2002;Hansen, Sandströ m, Jensen, & Sørensen,1997a, 1997bLopez-Huertas et al, 2006;Teucher et al, 2006;Walker et al, 2006). However, the mineral binding and absorption activities of casein hydrolysates have important implications in the treatment/prevention of diseases, which have been industrially exploited.…”