Calcium and Magnesium ATPase Activities in Women with Varying BMIs

Nasser, Jennifer A.; Hashim, Sami A.; Lachance, Paul

doi:10.1038/oby.2004.229

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…It has been shown that Mg is only elevated in cells with high Ca [52]. Nasser et al [53] found a positive correlation between Mg–ATPase activity and Ca–ATPase. They concluded that decreased Mg–ATPase activity may contribute to increased intracellular Ca.…”

Section: Biological Plausibility Of Magnesium and Calciummentioning

confidence: 99%

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Sahmoun

Singh

2010

Medical Hypotheses

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SUMMARY Breast cancer is the most commonly diagnosed cancer among United States (US) women. Established risk factors explain only about 13% of breast cancer incidence among women in the US. Thus, the cause of most cases of breast cancer remains unknown. In postmenopausal women, serum calcium (Ca) and serum magnesium (Mg) play an important role in skeletal health, cell proliferation and cancer. Mg is essential for DNA duplication and repair and Mg deficiency favors DNA mutations leading to carcinogenesis. Dietary intake of Mg in the US is less than the recommended amount, and the deficit is more pronounced in older individuals where gastrointestinal and renal mechanisms for Mg conservation are not as efficient. Furthermore, healthy postmenopausal women are frequently recommended to take supplemental Ca, but not Mg and vitamin D to maintain bone and overall health. Most women with hormone sensitive breast cancer are recommended to take aromatase inhibitors, which causes bone loss and thus are generally prescribed Ca and vitamin D, but not Mg. Although the association between serum Ca and breast cancer risk remains controversial, we hypothesize that this may be because Mg levels have not been accounted for. Mg level directly influences transient receptor potential melastatin 7 (TRPM7) related Ca influx, calcium–adenosine triphosphatase (Ca–ATP) levels, and cell proliferation, and thereby could lead to cancer. Thus a high serum Ca/Mg ratio is more appropriate and alterations in this ratio could lead to increased development of new and recurrent breast cancer.

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Section: Biological Plausibility Of Magnesium and Calciummentioning

confidence: 99%

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Sahmoun

Singh

2010

Medical Hypotheses

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“…S1 in the supplementary material), TRIC-B channels are not involved in cellular differentiation of alveolar epithelium. However, insufficient glycogen breakdown and phospholipid synthesis (Figs 3 and 4) probably result from compromised Ca 2+ handling in TRIC-B-knockout type II cells, as sugar and lipid metabolisms are controlled by several key Ca 2+ -dependent enzymes, including glycogen phosphorylase, pyruvate dehydrogenase and fatty acid synthase (Davis and Kauffman, 1986;Terrand et al, 2001;Nasser et al, 2004). The combination of reduced resting Ca 2+ levels and insufficient agonist-evoked Ca 2+ transients presumably inactivates these Ca 2+ -dependent enzymes, and thereby might inhibit the conversion of glycogen into phospholipids during the perinatal maturation of TRIC-B-knockout type II cells.…”

Section: Research Articlementioning

confidence: 99%

Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation

et al. 2009

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“…ATPase [44,45]. The results from this study show a slight increase in the activity of Ca 2+ Mg 2+ ATPase in the HFD treatment group, which suggest likely increases in erythrocyte intracellular Ca 2+ levels in this group.…”

Section: Discussionmentioning

confidence: 46%

Erythrocyte membrane integrity and protein activity in high-fat diet fed male Wistar rats

Ogbara

Adele²,

Ige³

et al. 2022

Nutrire

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High fat diet (HFD) has been reported to induce systemic in ammation and oxidative stress that may affect the structural integrity of erythrocytes and alter their ability to undergo deformation. This study was therefore designed to investigate the effect of HFD feeding on erythrocyte membrane integrity and protein activity in male Wistar rats. MethodsTen animals (100-120g) were grouped equally and exposed to either standard diet or HFD (25%-fat) for 42days. Thereafter, retro-orbital sinus blood was collected under anesthesia (thiopental) and aliquots were analyzed for erythrocyte sedimentation rate (ESR), osmotic fragility and mean corpuscular fragility.Erythrocyte ghost membranes were also isolated from blood sample aliquots and analyzed for total protein concentration, malondialdehyde (MDA), Na + K + -ATPase activity, Ca 2+ Mg 2+ -ATPase activity and intercellular adhesion molecule (ICAM)-4 level. ResultsOsmotic fragility and mean corpuscular fragility were signi cantly increased (P<0.05) in the HFD-fed group compared to control. ESR (mm/hr) (64.60±2.34 vs. 21.20±1.53), membrane MDA (µMol) (3.66±0.86 vs. 0.43±0.08) and ICAM-4 (ng/ml) (1.68±0.23 vs. 0.49±0.16) levels were also increased (P<0.05) in the group 2 (HFD) compared to group 1 (standard diet). Compared to standard diet group, erythrocyte membrane total protein concentration (10.46±0.96 vs 6.00±0.38 g/dl) and Na + K + ATPase activity (1.37±0.22 vs 0.22±0.03 x10 7 µmol pi/mg protein/hr) was reduced (P<0.05) in the HFD group while Ca 2+ Mg 2+ -ATPase exhibited a 27.9% increase in activity. ConclusionThis study suggests that high fat diet may compromise the structural and functional integrity of erythrocytes by activating systemic in ammation, erythrocyte membrane and protein oxidation as well dysregulated membrane ATPase activity required to maintain erythrocyte deformability in male Wistar rat.

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Calcium and Magnesium ATPase Activities in Women with Varying BMIs

Cited by 8 publications

References 38 publications

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation

Erythrocyte membrane integrity and protein activity in high-fat diet fed male Wistar rats

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