Calcium and Phosphorus Homeostasis on the First Day of Life

Hohenauer, L; Rosenberg, Th.; Oh, William

doi:10.1159/000240209

Cited by 31 publications

(14 citation statements)

References 6 publications

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“…These 2 infants did not lose any calcium or phosphorus in the urine up to 48 h of life. As regards phosphorus, this is contrary to the findings of Hohenauer et al [9], who found an increased phosphate clearance in IRDS during the first day of life. Case 5 reached the same low level of Cauf as cases 6 and 10.…”

Section: Discussioncontrasting

confidence: 99%

Plasma Calcium Fractions during the First Days of Life with Special Reference to Neonatal Hypocalcaemia

Bergman¹

1972

Neonatology

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Section: Discussioncontrasting

confidence: 99%

Plasma Calcium Fractions during the First Days of Life with Special Reference to Neonatal Hypocalcaemia

Bergman¹

1972

Neonatology

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“…In addition, the level of serum calcium is known to fall in tire immediate postnatal period (1,8,15). Hypofunction of the parathyroid gland in early neonatal life (1,10,34) and/or cessation of a maternal supply of calcium fol lowing umbilical cord ligation (7,22) have been implicated in this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

pH and the Level of Calcium in the Blood of Fetal and Neonatal Albino Rats

Krukowski¹,

Smith²

1976

Neonatology

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Near-term rat fetuses in utero are acidotic and hypoxic, and have high levels of total serum calcium. In the first hour of postnatal life, pO₂ and pH increase and pCO₂ and calcium fall. Between 1 and 4 h following birth, respiratory gases vary little, whereas pH continues to rise and calcium further declines. By 4 h, newborns reach normal pH levels but are markedly hypocalcemic. It is suggested that the Ê»hypercalcemia’ of intrauterine life is related to acidosis in utero, and that following birth, the initial fall in serum calcium is associated with the blowing off of CO₂ and a concomitant rise in pH. The later decline in circulating calcium is independent of alterations in respiratory gases and relates directly to the final correction of neonatal acidosis.

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“…They then remained relatively constant during the first 5 days of life. Levels of plasma magnesium which by themselves might lead to symptoms (i.e., < 1.0 mEq/liter) were observed only once; the simultaneous calcium ion activity in the plasma of this infant was (13) ± 0.28 (9) ± 0.26 (14) ± 0.35 (10) ± 0.20 (12) ± 0.26 (7) ± 0.30 (10) ± 0.09 (7) Ms, (8) ± 0.10 01) ± 0.10 (8) ± 0.08 (13) ± 0.08 (7) ± 0.31 (10) ± 0.12 (7) PO,, ± 0.47 (11) i ±0.52 (11) ± 0.84 (5) ± 0.41 (9) ± 0.42 ( 7.36 ± (9) 7.31 ± (11) 7.34 ± (5) 7.30 ± (7) -.…”

Section: Serial Magnesium Levelsmentioning

confidence: 78%

Calcium Ion Activity in the Sick Neonate: Effect of Bicarbonate Administration and Exchange Transfusion

et al. 1972

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ExtractCalcium ion activity was measured in plasma obtained by venous or arterial puncture using a calcium-selective flow-through electrode. Mean level of ionized calcium in umbilical venous plasma was 2.48 ± 0.04 mEq/liter. Within 30 hr after birth, the values decreased in sick infants to 1.35 ± 0.11 mEq/liter. Total calcium concentra tions were in the normal adult range at birth (5.20 ± 0.08 mEq/liter), showing a subsequent decline to subnormal values (3.47 ± 0.28 mEq/liter at age 30-40 hr). A calcium ion activity of less than 1.4 mEq/liter was associated with total calcium level" at or below 3 mEq/liter in 80% of patients. Symptoms and signs attributable to hypocalcemia (ionized fraction) or hypornagnesemia, or both, were found only in infants in whom plasma levels of both divalent cations were below the lower limit of normal. Administration of NaHGOs for acidosis caused a slight rise in pH (from 7.20 to 7.28 rnEq/liter) and a decrease in plasma calcium ion activity (from 1.68 to 1.51 mEq/liter). During exchange transfusion with acid-citrate-dextrose (ACD)-Tham buffered blood, calcium ion activity decreased significantly from 1.90 ± 0.08 to 1.20 ± 0.09 mEcj, liter, whereas total calcium levels increased consistently (from 4.22 db 0.13 to 5.33 ± 0.15 mEq/liter). SpeculationThe temporary hypocalcemia, observed in sick newborn infants, may also occur in healthy newborns. It is thought to initiate normal calcium homeostasis by stimulating parathormone secretion and by bringing into play the two feedback mechanisms for calcitonin and parathormone secretion.

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Calcium and Phosphorus Homeostasis on the First Day of Life

Cited by 31 publications

References 6 publications

Plasma Calcium Fractions during the First Days of Life with Special Reference to Neonatal Hypocalcaemia

Plasma Calcium Fractions during the First Days of Life with Special Reference to Neonatal Hypocalcaemia

pH and the Level of Calcium in the Blood of Fetal and Neonatal Albino Rats

Calcium Ion Activity in the Sick Neonate: Effect of Bicarbonate Administration and Exchange Transfusion

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