Calcium and sodium transport in gestational hypertension

Tranquilli, Andrea Luigi; Rabini, R. A.; Cugini, A; Cester, N.; Valensise, H.; Romaninï, Carlo; Bertoli, Enrico; Mazzanti, Laura

doi:10.1016/0167-5273(89)90093-4

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…The increase we observed in cord blood samples of fetuses from gestational diabetic and ges tational hypertensive mothers, in whom there was no difference in hematocrit com pared to controls, may therefore be consis tent either with a reduction in fibrinogen turnover [16] or with alterations in erythro cyte membrane function or composition. The latter (altered ion transport, increased cholesterol/phospholipid ratio, increased sphingomyelin, increased phosphatidylethanolamine, and reduced sialic acid) may in crease aggregation, although these findings are mainly observed in gestational hyperten sion [17] or in long-lasting type-I diabetes.…”

Section: Commentmentioning

confidence: 71%

Umbilical Cord Blood Rheology in Relation to Maternal Disease and Fetal Hypoxia

et al. 1989

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Erythrocyte aggregation was studied in 60 samples of cord blood taken at delivery from neonates whose mothers suffered from hypertension or diabetes in pregnancy or from neonates who showed hypoxia during labor. Eryhtrocyte aggregation significantly increased in the cord blood of neonates who suffered from hypoxia during labor, and in neonates from hypertensive and diabetic mothers. The effects of maternal disease or intrapartum hypoxia may therefore stimulate fetal erythropoiesis and cause major changes in cord blood rheology.

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Section: Commentmentioning

confidence: 71%

Umbilical Cord Blood Rheology in Relation to Maternal Disease and Fetal Hypoxia

et al. 1989

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“…Zeta potential (ZP) is an electrochemical property of cell surfaces that is determined by the net electrical charge of molecules exposed at the surface of cell membranes. Membrane proteins contribute to the total net electrical charge of cell surfaces and can alter ZP through changes in their intermolecular interactions [22]. Erythrocyte is one of the earliest and extensively analyzed blood cells in blood physiological and clinical studies [23].…”

Section: Discussionmentioning

confidence: 99%

“…In a cross-sectional study, Ozanne et al demonstrated that red cells aggregation increases during the course of normal pregnancy [28]. Whereas, in preeclampsia red blood cell aggregation is further increased when compared with normotensive pregnant women; this increase could be due to either the changes in fibrinogen system or functional abnormalities of erythrocyte membranes [22]. Andrea et al observed that erythrocyte aggregation was increased in all the hypertensive pregnant patients compared with the normotensive pregnant controls, regardless of both the onset (chronic or pregnancy-induced) of hypertension and the status of plasma macromolecules.…”

Section: Discussionmentioning

confidence: 99%

Alteration in Zeta Potential of Erythrocytes in Preeclampsia Patients

Karemore¹,

Avari²

2019

Prediction of Maternal and Fetal Syndrome of Preeclampsia

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Erythrocyte is one of the earliest and extensively analyzed blood cells in blood physiological and clinical studies. The erythrocyte membrane is negatively charged and sialic acid residues are responsible for most of the negative charge at the cell surface. This negative charge on the red blood cells (RBC) surface is believed to prevent RBC aggregation. This charge varies in different disease condition which can be determined by zeta potential (ZP) values. The present study deals with alteration in zeta potential of erythrocytes in preeclampsia patients. The mean erythrocytic ZP of control pregnant women taken during third trimester was found to be 21.64 ± 0.3122 mV whereas; when erythrocytic ZP of preeclampsia patients was measured it was found to be 15.13 ± 0.1393 mV which was significantly less than that of control pregnant volunteers. Alteration in zeta potential value was accompanied by endothelial damage which is able to mechanically deform and hemolyze erythrocytes as they pass through the capillaries. It was also observed from determination of lipid peroxidation of erythrocytes, that there is formation of higher concentration of malondialdehyde within the erythrocytes of preeclampsia patients. The data suggest that, in preeclampsia there is excessive accumulation of oxidative stress which causes injury to vascular endothelial cells by generation of lipid peroxides and detachment of sialic acid residues. As a result there is alteration in the net negative surface charge on RBCs extracellular membrane which leads to alteration in zeta potential value. Thus it can be concluded that zeta potential value of erythrocytes can act as a screening test to anticipate pregnancies at high risk for this complication.

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“…According to other authors (3,8), and consistently with our previous studies on pregnancy and hypertension (4,5,9), and also due to their larger availability, we chose the erythrocytes as the model for our study.…”

Section: Erythrocyte Sodium Activitymentioning

confidence: 99%

“…The involvement of cell cation homeostasis in hypertension has been widely demonstrated (1)(2)(3). We have previously reported an increase in red blood cell sodium and calcium concentrations, and a defect in their regulatory mechanisms, in pregnancyinduced hypertension (4,5). It has been postulated that an increase in intracellular sodium, at the level of perivascular smooth myocytes, may shift calcium bound to endocellular membranes, rendering it available for contraction.…”

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confidence: 98%