Calcium and the anaesthetist

Aguilera, I. M.; Vaughan, R. S.

doi:10.1046/j.1365-2044.2000.01540.x

Cited by 83 publications

(65 citation statements)

References 59 publications

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“…The Na + channel opener veratridine causes an abnormal entry of Na + ions followed by a secondary increase of the Ca 2+ concentration, leading to beating arrests because the Na + channel is unable to close [30]. of isradipine (15 µM) for inducing beating arrests was much higher than that for verapamil, most likely because this compound only blocks the L-type Ca 2+ channels.…”

Section: Discussionmentioning

confidence: 99%

In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing

Nicolas

Hendriksen

Haan

et al. 2015

Toxicology in Vitro

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In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing Nicolaas, J.; Hendriksen, P.J.M.; Haan, L.H.J. de; Koning, R.; Rietjens, I.M.C.M.; Bovee, T.F.H.This is a "Post-Print" accepted manuscript, which has been published in the "Toxicology in Vitro"This version is distributed under a non-commencial no derivatives Creative Commons (CC-BY-NC-ND) user license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and not used for commercial purposes. Further, the restriction applies that if you remix, transform, or build upon the material, you may not distribute the modified material.Please cite this publication as follows:

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Section: Discussionmentioning

confidence: 99%

In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing

Nicolas

Hendriksen

Haan

et al. 2015

Toxicology in Vitro

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“…Calcium gluconate gel (2.5%) is widely used for first aid and/or primary treatment of HF burns of the skin [22][23][24][25][26][27][28][29][30]. The gel is applied promptly and repeatedly onto the burned area, up to several hours.…”

Section: Acute Hazardous Effectsmentioning

confidence: 99%

Possible hazardous effects of hydrofluoric acid and recommendations for treatment approach: a review

2011

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Hydrofluoric acid (HF) is commonly used for conditioning the glass ceramics either prior to cementation or for intraoral repair in prosthetic and restorative dentistry. The present study offers a review of chemical properties of HF used, highlight the possible hazardous effects of this agent, and to recommend the treatment approach for potential risks. Available published information documented in PubMed, Medline, and Picarta literature databases was reviewed. Additional information was derived from scientific reports, medical and chemical textbooks, handbooks, product information, manufacturers' instructions, Internet web sites of the HF manufacturers. No report was found on the incidence of the hazardous effects of HF in dentistry. Reports from other fields presented incidences of acute and chronic symptoms in exposure to HF. While acute symptoms include skin or nail burns, chronic ones involve systemic toxicity, eye injuries, inhalation and ingestion-related symptoms that can be even fatal. HF can be harmful and particularly aggressive to soft tissues, but symptoms may not be apparent immediately after exposure. The hazardous effects are not based on the pH value, but on the toxicity of HF. Potential hazards of HF known from other applications than dentistry should be considered also in dental applications. Especially the clinicians, who often deal with adhesive cementation or repair of glass ceramics, should take necessary precautions for possible hazards of HF. Scientific reports, medical and chemical textbooks, handbooks, product information, manufacturers instructions, Internet web sites of the HF manufacturers were also referred. In dentistry, HF is most commonly used for conditioning the glass ceramics either prior to cementation or for intraoral repair.Exposure to HF can be harmful and may not be immediately apparent being particularly aggressive for soft tissues. This is not based on the pH value, but on its toxicity. Common routes of exposure are inhalation, dermal exposure and ingestion that lead to the general symptoms of toxicity such as lung injury, skin burns, systemic toxicity and painful necrotic lesions. General symptoms are skin burns, systemic toxication and eye irritation by fume exposure. No report was found on the hazardous effects of HF in dentistry. HF is commonly used to condition the ceramic surfaces prior to cementation or repair. Especially the clinicians, who often deal with glass ceramics, should take necessary precautions for possible hazards of HF.

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“…Cardiovascular function may be impaired in hypocalcaemia, and cardiac failure, hypotension, impaired rhythm, digital insensitivity and impaired β adrenergic effects may occur. Hypocalcaemia may also potentially activate the negative inotropic effects of barbiturates and volatile anaesthetics (22). These disturbances may result in hypotension, arrhythmia and prolonged muscle relaxation in critically ill patients during anaesthetic administration.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bowel Preparation and Fluid Restriction in Robot-Assisted Radical Prostatectomy Patients

Karaören¹,

Bakan²,

Yürük³

et al. 2015

Turk J Anesth Reanim

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Amaç: Robot yardımlı radikal prostatektomi (RYRP) ameliyatlarında preoperatif bağırsak hazırlığı ve intraoperatif sıvı kısıtlaması dehidratasyona ve elektrolit dengesizliğine neden olabilmektedir. Bu hastalarda yatış öncesi anestezi polikliniğinde "normal" olarak değerlendirilen labaratuvar değerleri anestezi uygulaması esnasın-da yanıltıcı olabilmekte ve hipokalsemi ve hipokalemiye bağlı kalp ritmi bozukluklarına, depolarizan blokta uzamaya ve anesteziden derlenmenin gecikmesine neden olabilmektedir. Biz çalışmamızda RYRP ameliyatlarında bağırsak temizliği ve sıvı kısıtlamasının preoperatif (T1) alınan labaratuvar değerleri ile ameliyat başlangıcın-da (T2) ve ameliyatın 6. saatinde (T3) alınan labaratuvar değerleri arasında bu tip yan etkilere yol açabilecek derecede farklılığa sebep olup olmadığını araştırmayı amaçladık.Yöntemler: American Society of Anesthesiologists (ASA) I-II 49 hasta uzerinde yaptığımız prospektif çalışmada hastaların bağırsak hazırlığı 12 saat içinde 2 defa rektal enema (NaP) ve tek doz oral soda (NaP) kullanılarak yapıldı. Ameliyat süresince 1 mL kg -1 h -1 %0,09 NaCl ve 1 mL kg -1 h -1 %6 HES 200/05 infüzyonları uygulandı.Bulgular: T2'de potasyum düzeyi T1 ve T3'e göre; T2 ve T3'teki kalsiyum düzeyi ise T1'e göre istatistiksel olarak anlamlı düşük saptandı. T3 kalsiyum değeri de T2'den anlamlı düşük, T3 kreatinin değeri ise T1 ile T2'den istatistiksel olarak yüksek saptandı.Sonuç: ASA I-II hasta grubunda yaptığımız çalışmamızda bağır-sak hazırlığı ve sıvı kısıtlamasına bağlı labaratuvar değerlerinde her ne kadar ciddi yükseliş ve düşüşler saptanmamış olsa da bu deği-şimler yüksek riskli ASA III-IV hastalarda önem taşıyabilir.Anahtar Kelimeler: Uzaktan operasyon (robotik), dehidratasyon, sıvı elektrolit imbalansı, barsak hazırlığı Objective: In Robot-assisted radical prostatectomy (RARP) patients, preoperative bowel preparation and intraoperative fluid restriction may cause dehydration and electrolyte imbalance. In these patients, laboratory results that are considered "normal" in the pre-anaesthesia clinic may be misleading, and cardiac arrhythmia due to hypokalaemia and hypocalcaemia, as well as problems, such as prolonged non-depolarising blockade and delayed recovery from anaesthesia, may be observed during anaesthesia practice. In this study, we aimed to determine these disturbances by comparing the preoperative (T1) laboratory values with those at the beginning of the operation (T2) and at the 6 th hour of the operation (T3) and values at discharge. Methods:This prospective study comprised 49 American Society of Anesthesiologists (ASA) I-II patients. Bowel preparation was made with a rectal enema (NaP) twice in 12 hours and with one single dose of oral laxative soda (NaP). During surgery, 1 mL kg -1 h -1 0.09% NaCl and 1 mL kg -1 h -1 6% HES 200/05 infusions were applied. Results:The potassium level at T2 was significantly lower than at T1 and T3. The calcium levels at T2 and T3 were significantly lower than at T1, and the level at T3 was significantly lower than at T2. The creatin...

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Calcium and the anaesthetist

Cited by 83 publications

References 59 publications

In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing

In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing

Possible hazardous effects of hydrofluoric acid and recommendations for treatment approach: a review

Effects of Bowel Preparation and Fluid Restriction in Robot-Assisted Radical Prostatectomy Patients

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