Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia

Veshchitskii, Aleksandr; Merkulyeva, Natalia

doi:10.1016/j.neuint.2023.105634

Neurochemistry International

2023

DOI: 10.1016/j.neuint.2023.105634

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Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia

Aleksandr Veshchitskii,

Natalia Merkulyeva

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2024

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Cited by 3 publications

References 211 publications

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Inter‐Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

Veshchitskii,

Shkorbatova,

Efimova

et al. 2024

J of Comparative Neurology

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Rat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti (DA) strains. The key findings include (i) distinct spatial relationships between vertebrae and spinal segments in the two strains; (ii) Wistar rats have larger volumes of spinal cord gray and white matter; (iii) DA rats have smaller total neuronal populations, thus indicating an expectation of smaller local neuronal populations; (iv) this expectation was confirmed for interneurons expressing calbindin 28 kDa. But contrary to expectations, (v) DA rats had more numerous populations of the interneurons expressing parvalbumin and a population of α‐motoneurons. Consequently, these strains displayed divergent ratios in specific spinal neuronal populations. Researchers should consider these inter‐strain differences when comparing data across different strains.

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Inter‐Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

Veshchitskii,

Shkorbatova,

Efimova

et al. 2024

J of Comparative Neurology

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Expression of Parvalbumin, Osteopontin and Glypican 4 in Neurons of Lumbar Region Distant from the Epicenter of Traumatic Spinal Cord Injury

Tutova,

Kabdesh,

Mukhamedshina

et al. 2024

J Evol Biochem Phys

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Expression of parvalbumin, osteopontin and glypican 4 in neurons of lumbar region distant from the epicenter of traumatic spinal cord injury

Tutova,

Kabdesh,

Mukhamedshina

et al. 2024

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

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Spinal cord injury (SCI) is manifested by pathologic changes in the areas significantly distant from the area of primary injury. In order to find new potential therapeutic targets to restore motor function, it is particularly relevant to identify the causes and mechanisms of these shifts in the lumbar spinal cord when injury occurs in the proximal spinal cord. On the model of dosed SCI the expression of Ca-binding protein parvalbumin (PARV), osteopontin (OPN) and glypican 4 (GPC4) in neurons of laminae VII, VIII and IX within segments L3–4 on 7 and 60 days of the experiment was studied. Laminas VII and IX show a decrease in the number of PARV+ neurons during the acute and chronic phase of SCI, which may indicate a decrease in calcium binding in ventral horn neurons at the level of segments L3–4. Decreased PARV expression in these neurons indicates an increased risk of their vulnerability and impaired motor function. The pattern of OPN expression in lumbar horn neurons distant from the epicenter of traumatic injury was studied for the first time. In all the studied laminae in the ventral horns of the gray matter, we did not observe shifts in the number of OPN+ neurons both in the acute and chronic phases of SCI. In lamina IX of the lumbar spinal cord, we found an increase in the number of GPC4+ neurons in the acute posttraumatic period, which can be regarded as a key positive adaptive reaction of neurons in the lumbar spinal cord remote from the epicenter of injury. The assessment of this reaction as positive is based on the data on the binding of GPC4 anchored on the neuron surface to various molecules with neuroprotective activity and stimulating neuroregeneration.

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Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia

Cited by 3 publications

References 211 publications

Inter‐Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

Inter‐Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

Expression of Parvalbumin, Osteopontin and Glypican 4 in Neurons of Lumbar Region Distant from the Epicenter of Traumatic Spinal Cord Injury

Expression of parvalbumin, osteopontin and glypican 4 in neurons of lumbar region distant from the epicenter of traumatic spinal cord injury

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