Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older

Washino, Satoshi; Ugata, Yusuke; Saito, Kimitoshi; Miyagawa, Tomoaki

doi:10.3390/jcm10081603

Cited by 5 publications

(9 citation statements)

References 28 publications

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“…The association of CCBs with nocturia has been reported in several studies [2,40]. Unlike other antihypertensive medications, clinically important nocturia is independently associated with the use of a CCB [40].…”

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 90%

“…Nocturia is associated with age and BPH, however its occurrence has also been associated with the use of some CCBs, from which it may be aggravated in pre-existing states [39]. The association of CCBs with nocturia has been reported in several studies [2,40]. Unlike other antihypertensive medications, clinically important nocturia is independently associated with the use of a CCB [40].…”

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

“…In their study, Washino et al noted that patients who took CCBs had more episodes of nocturia than the others [40]. The researchers evaluated nocturia using item 7 of the international prostate symptom score (IPSS) questionnaire, in their retrospective evaluation of men who were ≥ 40 years of age.…”

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

“…Higher incidence of nocturia is associated with CCBs than in aldosterone receptor antagonists, β-blockers, ACEIs and ARBs [3]. Age is also another notable factor associated with nocturia [40]. Mankowski et al noted that men with LUTS/benign prostatic hyperplasia preferred treatment that relived both urgency and day time/night time micturition as a compensation for potential side effects [41].…”

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

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Role of calcium channel blockers in lower urinary tract symptoms in benign prostatic hyperplasia: a literature review

2022

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Background Benign prostatic hyperplasia (BPH) and the use of CCBs are common in older persons, and are also associated with lower urinary tract symptoms (LUTS). This review summarised and synthesised relevant information and recent advances to improve clinical knowledge on the role of CCBs in LUTS, BPH symptoms and health-related quality of life. Main body of the abstract A search of databases of PubMed, Web of science, Hinari, and Google scholar was performed using several keywords. Relevant studies were also extracted from references of identified studies. Selected studies were assessed for content related to CCBs, BPH and LUTS, and the most relevant reports were included. The inhibition of calcium channels by CCBs interferes with influx of extracellular Ca2+ into the detrusor muscle, which interferes with bladder contraction and relaxation. Hence, CCBs are associated with precipitation or aggravation of urinary storage and voiding symptoms, which are also common symptoms of BPH. This suggests a potential aggravation of BPH symptoms with the use of CCBs. Short conclusion Persons at high risk of LUTS such as in BPH, may benefit from other classes of antihypertensive drugs. Therefore, it is essential to identify persons with BPH prior to commencement of therapy with CCBs. Patients on CCBs should be routinely reviewed for any potential precipitation or aggravation of LUTS. Patients should also be counselled to notify their healthcare provider of unusual urinary symptoms during CCB use. This will facilitate enhanced quality of life in patients with BPH.

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Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 90%

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

Section: Role Of Ccbs In Urine Storage Dysfunction (Nocturia) and Bphmentioning

confidence: 99%

See 2 more Smart Citations

Role of calcium channel blockers in lower urinary tract symptoms in benign prostatic hyperplasia: a literature review

2022

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“…Attention should be paid to the possible accentuation of nocturia, which is highly prevalent in patients with nighttime hypertension (typically found in overweight/obese patients with obstructive sleep apnoea), following the administration of CCB, especially if in monotherapy in the evening and not counteracted by an appropriate RAS inhibition. 74 …”

Section: Introductionmentioning

confidence: 99%

Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient

Sarzani

Laureti

Gezzi

et al. 2022

Therapeutic Advances in Chronic Disease

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Arterial hypertension is one of the major causes of cardiovascular morbidity and mortality worldwide. Effective and sustained reduction in blood pressure is essential to reduce individual cardiovascular risk. In daily clinical practice, single-pill fixed-dose combinations of different drug classes are important therapeutic resources that could improve both treatment adherence and cardiovascular risk management by targeting distinct pathophysiological mechanisms. The aim of this practical narrative review is to help physicians choosing the right single-pill fixed-dose combination for the right patient in the daily clinical practice, based on the individual clinical phenotype and cardiovascular risk profile.

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Prevalence of Sleep CALM nocturia factors in a male veteran population

Monaghan,

Fang,

Ksido

et al. 2024

Neurourology and Urodynamics

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IntroductionNocturia is a complex and multifactorial condition, associated with several genitourinary abnormalities as well as a host of conditions beyond the urinary tract, and thus often poses a significant diagnostic challenge in real‐world practice. Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications, the so‐called “Sleep C.A.L.M.” factors, are five common causes of nocturia requiring judicious evaluation according to current consensus guidelines. This study aims to assess the prevalence of the Sleep C.A.L.M. factors in a nocturia clinical population.MethodsRetrospective analysis of frequency‐volume charts from men with ≥2 nocturnal voids as well as concurrent demographic, clinical, and medical history data to identify patients with each of the Sleep C.A.L.M. factors. Comorbidities and medications were classified as a single group.ResultsA total of 213 subjects met the criteria for inclusion (median age 68.0 [63.5‐75.5] years). The prevalence of 1) sleep disorders, 2) comorbidities and/or medication use, 3) actions (i.e., modifiable behaviors/lifestyle factors), and 4) lower urinary tract dysfunction was 31%, 31%, 19%, and 41%, respectively. Among included participants, 73% were found to have at least 1 Sleep C.A.L.M. factor, and 33% had multiple Sleep C.A.L.M. factors. Results were similar upon stratification by age and nocturnal polyuria status.ConclusionsThe Sleep C.A.L.M. factors are highly common among nocturia patients in the clinical urology setting. Although many of these factors are strongly associated with advanced age in community‐based nocturia study samples, they appear common even among younger men in a nocturia patient population; the differential effect of age and individual Sleep C.A.L.M. factors on nocturia pathophysiology requires further investigation.

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Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older

Cited by 5 publications

References 28 publications

Role of calcium channel blockers in lower urinary tract symptoms in benign prostatic hyperplasia: a literature review

Role of calcium channel blockers in lower urinary tract symptoms in benign prostatic hyperplasia: a literature review

Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient

Prevalence of Sleep CALM nocturia factors in a male veteran population

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