2008
DOI: 10.1016/j.neuron.2008.09.005
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Calcium Channel Regulation and Presynaptic Plasticity

Abstract: Voltage-gated calcium (Ca(2+)) channels initiate release of neurotransmitters at synapses, and regulation of presynaptic Ca(2+) channels has a powerful influence on synaptic strength. Presynaptic Ca(2+) channels form a large signaling complex, which targets synaptic vesicles to Ca(2+) channels for efficient release and mediates Ca(2+) channel regulation. Presynaptic plasticity regulates synaptic function on the timescale of milliseconds to minutes in response to neurotransmitters and the frequency of action po… Show more

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Cited by 575 publications
(557 citation statements)
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References 204 publications
(336 reference statements)
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“…[85][86][87][88][89] At the molecular level, several factors are known to contribute to synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and the response of the postsynaptic neuron to those neurotransmitters. 87,[90][91][92][93] Long-term potentiation (LTP), one of several phenomena underlying synaptic plasticity, is widely considered to be one of the major cellular mechanisms involved in learning and memory. 86,94 Long-term memory and LTP of synapses share many similar properties, as both are triggered rapidly and depend on the synthesis of new proteins, and they can last for many months.…”
Section: General Anesthetics and The Neural Substrates Of Memorymentioning
confidence: 99%
“…[85][86][87][88][89] At the molecular level, several factors are known to contribute to synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and the response of the postsynaptic neuron to those neurotransmitters. 87,[90][91][92][93] Long-term potentiation (LTP), one of several phenomena underlying synaptic plasticity, is widely considered to be one of the major cellular mechanisms involved in learning and memory. 86,94 Long-term memory and LTP of synapses share many similar properties, as both are triggered rapidly and depend on the synthesis of new proteins, and they can last for many months.…”
Section: General Anesthetics and The Neural Substrates Of Memorymentioning
confidence: 99%
“…Voltage-gated calcium channels (VGCCs) mediate a number of neuronal functions including neurotransmitter release, neuronal excitation, neurite outgrowth, synaptogenesis, neuronal survival, differentiation and plasticity, as well as regulate gene expression [1][2][3]. VGCCs are molecular complexes comprised of α1, β, α2-δ, and γ subunits [1].…”
Section: Introductionmentioning
confidence: 99%
“…VGCCs are molecular complexes comprised of α1, β, α2-δ, and γ subunits [1]. The α1 subunit is essential for channel function and determines fundamental channel properties [1]. Genes encoding 10 pore-forming α1 subunits and several splice variants have been identified and characterized [4].…”
Section: Introductionmentioning
confidence: 99%
“…SNAP-25 is associated to cell membranes through palmitoylated cysteines that are located at the center of the protein 4,5 . SNAP-25 not only regulates exocytosis, but also negatively modulates different ion channels, including voltage-gated calcium channels (VGCCs) of N-type, P/Q-type and L-type 6 . Although SNAP-25 has a crucial role at the presynaptic level, a possible postsynaptic role of the protein has been proposed in the regulation of N-methyl-D-aspartate (NMDA) and kainate receptor (KAR) trafficking 7,8 .…”
mentioning
confidence: 99%