Abstract:Gcn5‐related N‐acetyltransferases (GNAT) are widespread across all domains of life and are capable of acetylating an assortment of substrates. However, many of their structures and functions remain unknown in bacteria. Our laboratory currently studies uncharacterized GNATs from Pseudomonas aeruginosa. We previously found the enzyme PA3944 acetylated polymyxin antibiotics and observed there was a duplicate GNAT gene (PA3945) with approximately 75% identity on the same operon. This protein has not been structura… Show more
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