Calcium-cross linked polysaccharide microcapsules for controlled release and antimicrobial applications

Jin, Yi; Zhou, Qi; Li, Zhenghui; Yang, Zehui; Fan, Hua‐Jun

doi:10.1016/j.colsurfa.2020.125025

Cited by 18 publications

(11 citation statements)

References 44 publications

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“…In textiles, active-containing microcapsules are grafted on textile fibers to release their content during the wearing of clothing [12,13]. In pharmaceutical applications [14,15], microcapsules can also offer various advantages including: an easy administration of the drug, a pre-programmed release profile to meet the therapeutic needs of the patient and an effective protection of drug against (e.g. enzymatic) degradation.…”

Section: Introductionmentioning

confidence: 99%

Cross-linking of double oil-in-water-in-oil emulsions: A new way for fragrance encapsulation with tunable sustained release

Stasse

Laurichesse

Vandroux

et al. 2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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This paper describes a new route to synthesize polymeric capsules with interesting and diverse diffusive and mechanical properties. Such capsules were obtained by free radical cross-linking copolymerization of the intermediate water phase of a double oil-in-water-in-oil (O/W/O) emulsion. Such a strategy allows separating the locus of polymerization from the fragrance-containing compartment. Indeed fragrance molecules are known to be reactive. The encapsulated species, also corresponding to the innermost oil, was a model fragrance composed of more than 10 various molecules usually used in perfumery. In a first step, the double emulsion containing a hydrophilic monomer, either Methacrylamide or Oligo(ethyleneglycol) methacrylate, and a hydrophilic cross-linker, either Tetra(ethyleneglycol) diacrylate or N,N-Methylene-bis-Acrylamide, was formulated. The influence of the cross-linker agent on the feasibility of the double emulsion was examined. Then, in a second part, the polymerization was performed. Four different systems of capsules were developed and compared in terms of diffusive and mechanical properties. We show that changing the monomer /cross-linker couple allowed modulating the capsule properties.

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Section: Introductionmentioning

confidence: 99%

Cross-linking of double oil-in-water-in-oil emulsions: A new way for fragrance encapsulation with tunable sustained release

Stasse

Laurichesse

Vandroux

et al. 2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…In the synthesis of polysaccharide-based nanomaterials, some reagents may cause unpredictable toxicity toward normal tissues because of the limited available toxicological information compared with numerous synthetic compounds. Therefore, synthetic approaches based on green chemistry, such as self-assembly via hydrogen bonding, hydrophilic/hydrophobic interactions, Van der Waals forces, and electrostatic interactions, have attracted increasing interest ( Han et al, 2020 ; Jin et al, 2020 ). Alqurshi et al synthesized nanoparticles for delivering prednisolone acetate based on chitosan and sodium deoxycholate as a counterion through self-assembly.…”

Section: Typical Ocular Polysaccharide-based Nanocarriers and Novel Dmentioning

confidence: 99%

“…They can be divided into homopolysaccharides (composed of single monosaccharides, such as starch and cellulose) and heteropolysaccharides (composed of different monosaccharides, i.e., mucopolysaccharide). The physical characteristics of polysaccharides suggest distinct structural and physicochemical features, including chemical composition, degree of polymerization, number of branches, and surface charge, which are advantageous for designing drug carrier systems with adjustable characteristics in terms of drug loading content, release capacity, and biodistribution ( Bernd et al, 2004 ; Furlani et al, 2019 ; Jin et al, 2020 ; Soliman et al, 2020 ). Compared with synthetic nanocarriers, polysaccharide-based nanomaterials exhibit a better performance in terms of drug retention and ocular permeability via the interpenetration of mucin chains, both directly and indirectly ( Servais et al, 2018 ; George and Suchithra, 2019 ; Pathak, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

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“…The design and fabrication of multifunctional hydrogel microparticles have recently attracted great interest because of their ability to put together various functions within a single entity [8]. One of the advantages of these microparticles is the ability to encapsulate numerous biologically active compounds that can provide targeted delivery of an encapsulated drug.…”

Section: Introductionmentioning

confidence: 99%

Multilayered Curcumin-loaded Hydrogel Microcarriers With Antimicrobial Function

Szczęsna¹,

Tsirigotis-Maniecka²,

Lamch³

et al. 2022

Preprint

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The design of multifunctional microcarriers has attracted significant attention because they combine various functions within a single system. In this study, we developed a set of multi-layered hydrogel microcarriers, which were first loaded with chemotherapeutic curcumin (CUR), then using the layer-by-layer (LbL) technique, coated through a polyelectrolyte shell consisting of chitosan (CHIT) or poly(allylamine hydrochloride) (PAH). As an outer layer with antimicrobial function, newly synthesised alkylene quaternary ammonium salt functionalised polyelectrolytes (A-QAS-PEs) were applied. For this purpose, poly(acrylic acid) (PAA) was decorated with dif-ferent hydrophobic side chains (n-hexane and n-dodecane side entities) and different degrees of substitution (m) of quaternary ammonium groups (abbreviated as PAA-C(O)O-(CH2)n-N+(CH3)3(m); n=6,12; m=8-14%). The grafting approach of PAA with the al-kylene quaternary ammonium salt moiety was performed under mild reaction conditions using Steglich esterification followed by quaternisation. The structure of antimicrobial decorated PAA was confirmed by 1H NMR and FTIR, and the mean diameter of all multifunctional microparticles was characterised by SEM. The viscoelastic properties of the functional layers were studied using QCM-D. The release of CUR from the microcarriers was described using a hybrid model, i.e., a combination of first-order kinetics and the Korsmeyer-Peppas model. The antimicrobial activity of functionalised PAA and multilayered CUR-loaded hydrogel microcarriers with quaternary am-monium function was assessed against Staphylococcus aureus and Serratia marcescens by the agar diffusion assay method. Only a limited inhibition zone of PAA was observed, but in the case of both antimicrobial decorated PAA and the corresponding multilayered nanocarriers, the inhibi-tory activity increase was achieved against both strains of bacteria.

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Calcium-cross linked polysaccharide microcapsules for controlled release and antimicrobial applications

Cited by 18 publications

References 44 publications

Cross-linking of double oil-in-water-in-oil emulsions: A new way for fragrance encapsulation with tunable sustained release

Cross-linking of double oil-in-water-in-oil emulsions: A new way for fragrance encapsulation with tunable sustained release

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Multilayered Curcumin-loaded Hydrogel Microcarriers With Antimicrobial Function

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