Calcium dobesilate prevents cisplatin-induced nephrotoxicity by modulating oxidative and histopathological changes in mice

Bazmandegan, Gholamreza; Fatemi, Iman; Kaeidi, Ayat; Khademalhosseini, Morteza; Fathinejad, Ali; Amirteimoury, Morteza

doi:10.1007/s00210-020-01990-3

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…Previous reports have also demonstrated that the administration of antioxidants, such as resveratrol and ascorbic acid, attenuates acute stress-induced anxiety by increasing the activity of antioxidant enzymes, such as SOD, GPx, and CAT [ 24 , 25 , 26 ]. CaD has previously been shown to mitigate oxidative stress during cardiac surgery [ 27 ] and increase the activity of antioxidant enzymes, such as SOD and GPx [ 13 , 27 , 28 , 29 ]. Here, we demonstrated that the administration of CaD, an angiopreventive drug clinically approved for the treatment of diabetic retinopathy [ 30 ], inhibited oxidative stress as revealed by decreased MDA levels and the increased activity of the antioxidative enzymes SOD, GPx, and CAT in brain homogenates.…”

Section: Discussionmentioning

confidence: 99%

“…Calcium dobesilate (CaD) is an established vasoactive and angioprotective drug (Doxium ® , OM PHARMA, Meyrin, Switzerland) commonly used to treat diabetic retinopathy and chronic venous insufficiency, reducing vascular permeability [ 11 , 12 ]. Previous studies also reported the antioxidant properties of CaD [ 13 , 14 ]. It is a potent free radical scavenger in the retina and reduces the level of malondialdehyde (MDA), inhibiting lipid peroxidation [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is a potent free radical scavenger in the retina and reduces the level of malondialdehyde (MDA), inhibiting lipid peroxidation [ 14 ]. Moreover, CaD increases the activity of antioxidant enzymes [ 13 , 15 ]. It has been also demonstrated that CaD could reduce cognitive impairment in animal models of Alzheimer’s disease via its anti-inflammatory and antioxidant properties [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

et al. 2021

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The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical treatment of diabetic retinopathy and chronic venous insufficiency. It has antioxidant properties and controls vascular permeability. In the current study, we evaluated the protective effects of CaD (50 and 100 mg/kg/day p.o.) in male mice treated with D-gal (500 mg/kg/day p.o.) for six weeks. Results demonstrated that body weight loss, anxiety-like and cognitive impairments of D-gal-treated animals were reversed by CaD administration as evaluated by the measurement of mice performance in elevated plus-maze, Y-maze, and shuttle box tests. CaD treatment also inhibited the oxidative stress in aging mouse brains by decreasing malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) enzyme activities. These results could open new perspectives for the clinical use of CaD in treating and preventing cognitive impairment in older people.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

et al. 2021

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“…Additionally, the activity of glutathione (GSH) as a cysteine-rich tripeptide with non-enzymatic antioxidant activity with a reactive thiol group has reductive efficacy by interacting directly with ROS 53 . The reduction in GSH levels caused by CDDP indicates a change in cellular redox state, implying that the cells are more susceptible to ROS 52 .…”

Section: Discussionmentioning

confidence: 99%

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Hafez

Kotb

El-Khayat

et al. 2022

Sci Rep

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The toxicity of cisplatin (CDDP) toward the renal tubules and its severe effects on the proximal tubules limits its further use in cancer therapy. The current study was undertaken to evaluate the protective effects of gallic acid-grafted O-carboxymethyl chitosan (GA@CMCS) against nephrotoxicity induced by CDDP in rats. Renal injury was assessed in the GA@CMCS/CDDP-treated rats using kidney injury molecule-1 (KIM-1). Moreover, the levels of reduced glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were measured. The comet assay was performed to measure the DNA damage. The renoprotective activity of GA@CMCS was supported by histo- and immuno-pathological studies of the kidney. GA@CMCS significantly normalized the increases in kidney homogenate of KIM-1, MDA, and NO-induced by CDDP and significantly increased GSH as compared with the CDDP group. GA@CMCS also significantly protects rat kidneys from CDDP-induced histo- and immuno-pathological changes. Both biochemical findings and histo- and immuno-pathological evidence showed the renoprotective potential of GA@CMCS against CDDP-induced oxidative stress, inflammation, and renal dysfunction in rats. In conclusion, GA@CMCS has been shown to mitigate the nephrotoxicity impact of CDDP in cancer therapy.

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“…D-Galactose (D-gal; Sigma-Aldrich, Germany, 500 mg/ kg) [22][23][24] and CaD (OM PHARMA, Switzerland, 50 or 100 mg/kg) [25] were orally administered using the standard drinking water.…”

Section: Drugsmentioning

confidence: 99%

Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage

Hakimizadeh

Heidari

Giménez‐Llort

et al. 2022

Fundamemntal Clinical Pharma

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Calcium dobesilate (CaD) is used for the treatment of diabetic retinopathy and nephropathy. This agent exerts antioxidant effects. In the present study, we evaluated the protective effects of oral administration of CaD against hepatorenal damages in a mice model of aging induced by D-galactose (Dgal). We used 28 male albino mice, which equally and randomly were divided into four groups as follows: intact, aging (D-gal at the dose of 500 mg/kg, p.o.), aging + CaD 50 (D-gal plus CaD at the dose of 50 mg/kg), and aging + CaD 100 (D-gal plus CaD at the dose of 100 mg/kg, p.o.). All drugs were administered orally once a day for 42 days. The liver and kidney damages were evaluated by measuring mass indices, levels of serum creatinine and blood urea nitrogen, and activities of serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and by histopathological evaluation. Moreover, hepatic and renal tissue oxidant/ antioxidant markers (malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase) were measured. The results showed that D-gal treatment induced significant oxidative stress in the kidney and liver that was paralleled by dysfunctions and histological alterations of these organs. CaD significantly improved the liver and kidney indices, implemented functional capacity of the liver and kidney, as well as decreased oxidative stress

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Calcium dobesilate prevents cisplatin-induced nephrotoxicity by modulating oxidative and histopathological changes in mice

Cited by 13 publications

References 34 publications

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage

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