Calcium-Enriched Nanofibrillated Cellulose/Poloxamer in-situ Forming Hydrogel Scaffolds as a Controlled Delivery System of Raloxifene HCl for Bone Engineering

Kamel, Rabab; El-Wakil, Nahla A.; Elkasabgy, Nermeen A.

doi:10.2147/ijn.s323974

Cited by 4 publications

(2 citation statements)

References 94 publications

(100 reference statements)

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“…The upregulation of mRNA and protein expression levels of osteogenesis-related genes was also observed [61]. In contrast, in situ hydrogels fabricated with calcium-enriched nano-fibrillated cellulose exhibited improved biocompatibility, cell attachment, alkaline phosphatase, and calcium deposition activity [62]. Hydroxyapatite, being one of the most biocompatible agents, combined with cellulose to develop into nanocomposites for bone cell proliferation, were three-dimensionally printed and evaluated for the sustained release of strontium and calcium ions and substantial proliferation, bone marrow stem cell differentiation, and bone tissue revival [63].…”

Section: Cellulosementioning

confidence: 95%

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee

Madhyastha

2023

JNT

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Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and reparation. The engineering of theragnostic nanomaterials has opened up avenues for disease diagnosis, imaging, and therapeutic treatments. The instantaneous monitoring of therapeutic strategy is expected to co-deliver imaging and pharmaceutical agents at the same time, and nanoscale carrier moieties are convenient and efficient platforms in theragnostic applications, especially in soft and hard tissue regeneration. Furthermore, imaging modalities have extensively contributed to the signal-to-noise ratio. Simultaneously, there is an accumulation of high concentrations of therapeutic mediators at the defect site. Given the confines of contemporary bone diagnostic systems, the clinical rationale demands nano/biomaterials that can localize to bone-diseased sites to enhance the precision and prognostic value for osteoporosis, non-healing fractures, and/or infections, etc. Furthermore, bone theragnostics may have an even greater clinical impact and multimodal imaging procedures can overcome the restrictions of individual modalities. The present review introduces representative theragnostic polymeric nanomaterials and their advantages and disadvantages in practical use as well as their unique properties.

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Section: Cellulosementioning

confidence: 95%

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee

Madhyastha

2023

JNT

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“…In vitro, the biocompatibility and osteogenesis demonstrated a higher level of ALP and calcium ion. 16 It is worth noting that for most of the current studies, osteogenesis in normal bone defects rather than that in ischemic bone defects is the focus of their studies. These scaffolds may induce fibrous tissue formation at the bone defect site under ischemic conditions, resulting in the failure to treat bone defects.…”

Section: Introductionmentioning

confidence: 99%

A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair

Xu¹,

Gan²,

Wang³

et al. 2022

IJN

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Introduction Bone delay union is mostly caused by lack of blood supply. Although autografts, allografts and artificial bone have been widely used to treat bone delay union, the bone regeneration fails in the ischemic site accompanied by the bone donor site complications and disease transmission. Recently, there is a growing recognition of the importance of hydrogel scaffolds which are regarded as an eligible engineer tissue for bone repair. However, hydrogel is still limited in improving neovascularization. Methods In this work, black phosphorus nanosheet and deferoxamine (BPN-DFO) were loaded in the gelatin hydrogel to overcome the high risk of bone delay union and systemically investigated the regeneration capability of BPN-DFO hydrogel in vitro and vivo. Results The resulting BPN-DFO hydrogel scaffold showed superior swollen, degradation and release rate, as well as satisfied biocompatibility. BPN-DFO hydrogel shown the significant up-expression of mRNA related to bone regeneration and cell proliferation. In vivo, the proposed BPN-DFO hydrogel significantly improved osteogenesis and neovascularization in the ischemic tibial bone site of SD rats with acute femoral artery occlusion. Both macroscopic and histological evaluation of new regenerated bone showed newly formed blood vessel and collagen using BPN-DFO hydrogel. The immunohistochemistry and RT-PCR revealed that the bone regeneration could be improved via BMP/Runx2 pathway. Conclusion The BPN-DFO hydrogel possesses potential tissue engineer material for ischemic bone defect treatment. However, furthermore studies are needed to testify the safety and efficacy of BPN-DFO hydrogel.

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