Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice

The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

“…63,64 Additionally, boron supplementation has several medical applications, such as in aging, 58,65 improving bone health, 66,67 improving cardiac health after myocardial infarction, 68 antiseptic, 69 antibiotic, 70 and hormone regulation. 56,71−73 Similarly, fructoborate (2), a naturally occurring borate ester, acts as an antioxidant 74 and antiinflammatory agent that likely affects treatment of knee/joint function, osteoporosis, osteoarthritis, 73,75−77 cancer, 60,78,79 and/or cognitive health. 59,80 Thus, naturally occurring boroncontaining compounds (BCC) warrant further exploration as mechanistic insight into the role of boron in animal health will guide the design of novel therapeutics.…”

“…However, the essentiality of boron in supporting animal life is substantiated by the detrimental effects of boron deficiency, such as impeding embryo development, − pulmonary fibrosis, osteoporosis, − cognitive function, , calcium and magnesium concentration, − and steroid hormone concentration. , As boric acid and borates enter animal/human cells, they interact with and often disrupt the kinetics and dynamics of other biomolecules containing cis -diols, such as flavin adenine dinucleotide, nicotinamide adenine dinucleotide (NAD), ribonucleic acids, ribonuclease, and S-adenosyl methionine (SAM). , Although disruptive in certain cases, supplementation with boric acid in humans at doses of 20–60 mg/day has been effective for the treatment of arthritis, certain types of neoplasia, − heart function, and metabolic disorders. , Additionally, boron supplementation has several medical applications, such as in aging, , improving bone health, , improving cardiac health after myocardial infarction, antiseptic, antibiotic, and hormone regulation. ,− Similarly, fructoborate ( 2 ), a naturally occurring borate ester, acts as an antioxidant and anti-inflammatory agent that likely affects treatment of knee/joint function, osteoporosis, osteoarthritis, ,− cancer, ,, and/or cognitive health. , Thus, naturally occurring boron-containing compounds (BCC) warrant further exploration as mechanistic insight into the role of boron in animal health will guide the design of novel therapeutics.…”

Calcium fructoborate regulate colon cancer (Caco‐2) cytotoxicity through modulation of apoptosis

“…[30] The most known SBE, calcium fructoborate (CaFB) has been demonstrated to have beneficial effects on health. [31,34] In a recent study from our lab, we have demonstrated that CaFB has preventive effects on skin cancer development by regulating apoptosis together with protein and mRNA expression levels of Akt and PTEN. [34] Although CaFB has been detected to regulate Akt and PTEN in skin cancer its regulatory mechanism on PI3K/Akt pathway required more investigation.…”

“…[ 31,34 ] In a recent study from our lab, we have demonstrated that CaFB has preventive effects on skin cancer development by regulating apoptosis together with protein and mRNA expression levels of Akt and PTEN. [ 34 ] Although CaFB has been detected to regulate Akt and PTEN in skin cancer its regulatory mechanism on PI3K/Akt pathway required more investigation. Moreover, the effects of CaFB on autophagy and apoptosis remain to be elucidated.…”