Calcium Hydroxide versus Mineral Trioxide Aggregate for Direct Pulp Capping: A Cost-effectiveness Analysis

Schwendicke, Falk; Brouwer, Fredrik; Stolpe, Michael

doi:10.1016/j.joen.2015.08.019

Cited by 36 publications

(31 citation statements)

References 27 publications

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“…Some studies have suggested that the effect of using calcium hydroxide or glass-ionomer cement on dentine caries is not superior to the use of an inert material (such as wax; Corralo & Maltz 2013), in indirect pulp capping of primary (Marchi et al 2006, Casagrande et al 2010, Schwendicke et al 2015 or permanent teeth (Baratieri et al 2002, Whitworth et al 2005, Wegehaupt et al 2009, Pereira et al 2017). Some studies have suggested that the effect of using calcium hydroxide or glass-ionomer cement on dentine caries is not superior to the use of an inert material (such as wax; Corralo & Maltz 2013), in indirect pulp capping of primary (Marchi et al 2006, Casagrande et al 2010, Schwendicke et al 2015 or permanent teeth (Baratieri et al 2002, Whitworth et al 2005, Wegehaupt et al 2009, Pereira et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, with the progress of regenerative and molecular approaches, it is known that the efficacy of direct and indirect pulp capping might be affected by the biomaterials used and their biological properties. Some studies have suggested that the effect of using calcium hydroxide or glass-ionomer cement on dentine caries is not superior to the use of an inert material (such as wax; Corralo & Maltz 2013), in indirect pulp capping of primary (Marchi et al 2006, Casagrande et al 2010, Schwendicke et al 2015 or permanent teeth (Baratieri et al 2002, Whitworth et al 2005, Wegehaupt et al 2009, Pereira et al 2017). On the other hand, for direct pulp capping an overall success rate of 80.5% for MTA has been reported when compared with calcium hydroxide (59% success rate) up to 123 months (Mente et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Disclosing the physiology of pulp tissue for vital pulp therapy

2018

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The discovery that dentine is a reservoir of bioactive molecules that can be recruited on demand has attracted efforts to develop new protocols and materials for vital pulp therapy (VPT). The noncollagenous proteins (NCPs) present in the dentine extracellular matrix (ECM) include growth factors (TGF-β1, BMP-7, FGF-2, IGF-1 and IGF-2, NGF and GDNF), extracellular matrix molecules (DSP, DPP, BSP, DMP-1 and DSPP) and both anti-inflammatory and pro-inflammatory chemokines and cytokines (TNF-α, IL-1, IL-6 and IL-10). Molecules such as DSP and DPP are mainly expressed by odontoblasts, and they are cleaved products from dentine sialophosphoprotein (DSPP). Some molecules, such as TGF-β1, specifically interact with decorin/biglycan in dentine. Although TGF-β1 increases the expression and secretion of NGF in human pulp cells, NGF induces mineralization and increases the expression of DSPP and DMP-1. Furthermore, GDNF may act as a cell survival factor and mitogen during tooth injury and repair. Pulp capping materials, such as MTA and calcium hydroxide, can solubilize bioactive dentine molecules (TGF-β1, NGF and GDNF) that stimulate tertiary dentinogenesis. The binding of these signalling molecules leads to activation of several signalling transduction pathways involved in dentinogenesis, odontoblast differentiation and inflammatory responses, such as the p38 MAPK, NF-kβ and Wnt/β-catenin signalling pathways. Understanding the cascade of cellular and molecular events underlying the repair and regeneration processes provides a reasonable new approach to VPT through a targeted interaction between tooth tissue and bioactive molecules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disclosing the physiology of pulp tissue for vital pulp therapy

2018

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“…, Schwendicke et al. , ). Fourth, the model used a tooth‐level approach to reduce the complexity of both the model and its interpretation.…”

Section: Discussionmentioning

confidence: 98%

Cost‐effectiveness of regularversusirregular supportive periodontal therapy or tooth removal

Schwendicke

Stolpe

Plaumann

et al. 2016

J Clinic Periodontology

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“…The literature often cites the high cost of MTA being a major barrier to its use in clinical practice despite a widely held view that for procedures such as direct pulp capping, it is the material of choice (6,(13)(14)(15)(16)(17). The mismatch between the evidence from the literature and the patterns of clinical practice suggests that there may be factors other than cost that influence the material selection by GD and PD.…”

Section: Discussionmentioning

confidence: 99%

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

Ha¹,

Kahler²,

Walsh³

2017

Eur Endod J

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Objective: The purpose of this study was to assess the restorative choices for pulpal therapy by members of the Australian and New Zealand Society of Paediatric Dentistry (ANZSPD). Methods: Members of the ANZSPD were sent an online survey asking about the procedures that they performed and their choice of dental materials. Results: The respondents were 31 general dentists (GD) and 55 specialist paediatric dentists (PD). Materials used for indirect pulp capping included calcium hydroxide [Ca(OH) 2 ] cement (CHC), glass ionomer cement or resin-modified glass ionomer cement (GIC/RMGIC), Ca(OH) 2 paste (CHP) and mineral trioxide aggregate (MTA). Materials for direct pulp capping included MTA, CHP and CHC. Materials and techniques used for pulpotomy included MTA, ferric sulphate, formocresol and diathermy, CHP and CHC. GD and PD were similar in their choice of materials. However, there was no preferred product for pulp therapy. Most GD learnt how to use MTA from CPD lectures, while some PD learnt how to use MTA from their postgraduate training as well as CPD lectures. Many GD and PD did not have hands-on training from their education on how to use MTA (GD: 80%, PD: 43%). Most would like to attend hands-on MTA courses (GD: 86%, PD: 65%). Conclusion: There was no clear preferred product for the various types of pulp therapy in paediatric dentistry. Education appears to be the major barrier to the use of MTA rather than the cost of MTA.

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Calcium Hydroxide versus Mineral Trioxide Aggregate for Direct Pulp Capping: A Cost-effectiveness Analysis

Cited by 36 publications

References 27 publications

Disclosing the physiology of pulp tissue for vital pulp therapy

Disclosing the physiology of pulp tissue for vital pulp therapy

Cost‐effectiveness of regularversusirregular supportive periodontal therapy or tooth removal

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

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