Calcium influx and release mechanism(s) in histamine-induced myometrial contraction in buffaloes

Sharma, Abhıshek; Choudhury, Soumen; Nakade, Udayraj P.; Yadav, Rajkumar Singh

doi:10.1016/j.anireprosci.2014.02.010

Cited by 6 publications

(5 citation statements)

References 32 publications

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Section: Histaminementioning

confidence: 99%

“…Aberrant uterine contraction may lead to certain pathological states such as preterm labor, dysfunctional labor, and powerful contractions at term leading to fetal hypoxia and distress. H1R was reported in buffalo myometrium and found to have an important role in regulating myometrial contractility during normal and pathological states [104]. Wang et al [105] demonstrated that high expression of H2R and low expression of H1R in the endometrial tissue impaired the inflammatory immune response and prevented excessive uterine tissue damage in metritis cows.…”

Section: Histaminementioning

confidence: 99%

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Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Alhussien

Dang

2020

Vet World

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Dairy cows are exposed to various stressors during their production cycle that makes them more susceptible to various diseases. Phagocytes (neutrophils and macrophages) are important soldiers of the innate immune system. Neutrophils are the first responders to an inflammatory response and stress and kill pathogens by generating reactive oxygen species and by the release of various antimicrobial peptides, enzymes, neutrophil extracellular trap formation, etc. Macrophages, the other phagocytes, are also the cleanup crew for the innate immune system that removes debris, pathogens, and dead neutrophils later on after an inflammatory response. The neuroendocrine system along with phagocytes exhibits an immunomodulatory potential during stressful conditions. Neuroendocrine system directly affects the activity of phagocytes by communicating bidirectionally through shared receptors and messenger molecules such as hormones, neurotransmitters, or cytokines. Different immune cells may show variable responses to each hormone. Short time exposure to stress can be beneficial, but repeated or extended exposure to stress may be detrimental to the overall health and well-being of an animal. Although some stresses associated with farming practices in dairy cows are unavoidable, better understanding of the interactions occurring between various stress hormones and phagocytic cells can help to reduce stress, improve productivity and animal welfare. This review highlights the role played by various stress hormones in modulating phagocytic cell performance of dairy cattle under inflammatory conditions.

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Section: Histaminementioning

confidence: 99%

Section: Histaminementioning

confidence: 99%

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Alhussien

Dang

2020

Vet World

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“…Calcium is the primary signal for activation of smooth muscle contractile proteins and it plays an important role in generating uterine myogenic spontaneity (Tribe 2001) or uterotonic effect of spasmogens (Sharma et al 2014). Significant attenuation of lead-induced myometrial contraction in buffalo myometrium in Ca 2+ -free RLS in the present study suggests dependence of uterotonic effect of lead on extracellular Ca 2+ and L-type Ca 2+ channels seem to play major role in initiation of contractile effect and this observation is in conformity with the report of Sharma et al (2014) in histamine-induced myometrial contractions in buffaloes. Extracellular calcium-dependent contractile effect of lead has also been reported in rabbit mesenteric artery (Watts et al 1995) and canine tracheal smooth muscles (Sopi et al 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Tissue preparation and tension measurements: Tissue preparation and tension measurements were done as per Sharma et al (2014). Effect of lead on tonic and phasic contractions and alterations in amplitude and frequency of myometrial spontaneity was recorded in isolated myometrial strips of buffaloes up to a maximum concentration of 0.1mM (10 -4 M) starting from 0.1nM (10 -10 M).…”

Section: Chemicals: Dilutions Of the Required Concentration Werementioning

confidence: 99%

“…Data recording and statistical analysis: Mean integral tension (MIT) for 8 min along with E max and EC 50 values were calculated as per Sharma et al (2014). Isometric developed tension (IDT) values were obtained by measuring the mean amplitude of all the contractions recorded over a period of time and frequency of contraction was determined as the mean number of contractile cycles observed during the same period (Chaud et al 1997).…”

Section: Chemicals: Dilutions Of the Required Concentration Werementioning

confidence: 99%

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Calcium-dependent and calcium-mimicking pathways regulate lead-induced myometrial contraction in water buffaloes

Nakade

Sharma

Choudhury

et al. 2017

Indian J of Anim Sci

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Lead produced dose-dependent contractile effect on buffalo myometrium and it was more marked on tonicity and amplitude while almost negligible on phasic contractions and frequency. In the presence of Ca2+-free Ringer Locke solution (RLS) and nifedipine, lead-induced uterotonic effect was significantly attenuated with decrease in Emax thus, suggesting major role of extracellular Ca2+ in uterotonic effect of lead and involvement of L-type Ca2+-channels in mediating this response. Direct excitatory effect of cyclopiazonic acid (CPA) on myometrium indicates possible Ca2+-influx via store operated calcium channels (SOCC). Lead failed to evoke any excitatory effect in the concurrent presence of nifedipine (1μM) and CPA (10μM), thus intracellular calcium seems to have negligible role in lead-induced myometrial contraction. In Ca2+-free high K+ (80 mM) depolarizing solution, lead-induced excitatory effect was attenuated by GF 109203X; which suggests permeation of lead through L-type Ca2+ channels to replace Ca2+ which directly activates protein kinase C (PKC) to produce excitatory effect. Thus lead seems to interact with calcium in buffalo myometrium in a dynamic fashion and exerts calcium-depending and calcium-mimicking effects; and therefore, lead is likely to have adverse effect on reproductive functions in buffaloes.

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Calcium signaling cascades differentially regulate PGF2α-induced myometrial contractions in water buffaloes (Bubalus bubalis)

Sharma

Nakade

Raut

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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Calcium influx and release mechanism(s) in histamine-induced myometrial contraction in buffaloes

Cited by 6 publications

References 32 publications

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Calcium-dependent and calcium-mimicking pathways regulate lead-induced myometrial contraction in water buffaloes

Calcium signaling cascades differentially regulate PGF2α-induced myometrial contractions in water buffaloes (Bubalus bubalis)

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