Calcium intake, serum vitamin D and obesity in children: is there an association?

Cunha, Kelly Aparecida da; Magalhães, Elma Izze da Silva; Loureiro, Laís Monteiro Rodrigues; Sant’Ana, Luciana Ferreira da Rocha; Ribeiro, Andréia Queiróz; Novaes, Juliana Farias de

doi:10.1016/s2359-3482(15)30054-3

Cited by 20 publications

(27 citation statements)

References 35 publications

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“…The inverse association between vitamin D levels and central obesity might be explained by the role of vitamin D in absorption of calcium. It has been shown that calcium intake and high levels of calcium are associated with lower adiposity (32). In addition, the elevated intact parathyroid hormone (iPTH) observed in subjects with low 25(OH)D3 levels might play a causal role in the pathogenesis of increased adiposity (33).…”

Section: Discussionmentioning

confidence: 99%

The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study

Tian

Shi

Zhou

et al. 2019

J Nutr Sci Vitaminol

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The association of serum vitamin D deficiency and metabolic risk factors in Chinese adults with prediabetes (PreDM) has not been investigated. The present study aimed to investigate the association of serum vitamin D deficiency and metabolic risk factors in Chinese adults with PreDM. In this cross-sectional study, we stratified 412 PreDM patients into vitamin D sufficient, vitamin D insufficient and vitamin D deficient subgroups. The physical examination data was collected. Serum 25-hydroxyvitamin D3 [25(OH)D3] were measured by high performance liquid chromatography. The prevalence of vitamin D deficiency and insufficiency in PreDM patients were 30.58% and 26.70%, respectively. Compared with the vitamin D deficient group, the prevalence of metabolic syndrome, central obesity, hyperglycemia and hypertension were higher than those in the vitamin D insufficient or sufficient group (p,0.05). Moreover, the prevalence of dyslipidemia in the vitamin D deficient group was higher than those in the vitamin D sufficient group (p,0.05). We observed an inverse relationship between 25(OH)D3 levels and waist circumference, triglyceride, and serum uric acid (b520.315; b520.134; b520.239), a positive relationship between 25(OH)D3 levels and high-density lipoprotein cholesterol (b50.197) after adjusting for age, sex and body mass index. Vitamin D deficiency is very common among PreDM patients in China and this deficiency is related to metabolic risk factors.

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Section: Discussionmentioning

confidence: 99%

The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study

Tian

Shi

Zhou

et al. 2019

J Nutr Sci Vitaminol

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“…These modifiable risk factors include dietary habits, as dietary intervention is an important aspect in the treatment of obesity [7]. While it is commonly accepted that various combinations of macronutrients are able to regulate body mass, there is a need to further explore the effects of different micronutrients on body adiposity values [3,7,8]. Among different micronutrients, calcium and vitamin D intake may influence obesity and other health characteristics [9].…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Calcium Intake and Adiposity in Male Adolescents

et al. 2019

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The aim was to investigate the possible association of dietary calcium intake with adiposity, insulin resistance, and adipocytokine values in adolescent boys. In this cross-sectional study, participants were 123 adolescent boys aged 13–15 years, who were divided into tertiles according to their dietary calcium intake. Dietary calcium intake was assessed using three 24 h dietary recalls. In addition, energy intake, body composition, physical activity (PA), and blood biochemical values were also measured. Mean body fat%, fat mass (FM), trunk FM, trunk fat%, and leptin differed between high and low tertiles of calcium intake after adjustment for age, pubertal stage, and PA. For the entire cohort, mean calcium intake was 786 ± 380 mg/day and was related to body mass index (BMI), FM, and trunk fat% but not to insulin resistance or adipocytokine values after adjusting for possible confounders. In addition, only 15.4% of the participants obtained or exceeded their mean dietary calcium intake requirements. These subjects who met their dietary calcium intake had significantly lower body fat% in comparison with subjects not meeting their dietary calcium intake. Odds ratio of being in the highest tertile of FM, trunk FM, and trunk fat% was 3.2–4.4 (95% confidence interval 1.19–12.47; p < 0.05) times higher for boys in low calcium intake tertile, compared to those boys in high calcium intake tertile. In conclusion, dietary calcium intake is inversely associated with total body and abdominal adiposity values in a specific group of healthy male adolescents with different body mass values.

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“…Additionally, obese people tend to commonly consume vitamin-poor diets which may be responsible for the low vitamin D levels seen in obesity. 3 Advances in research suggested that vitamin D deficiency may be a major contributor to obesity-related ramifications including impaired glucose tolerance (IGT), insulin resistance (IR) eventually leading to type 2 diabetes mellitus. Vitamin D receptor has been found in nearly each tissue type, including those essential for glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

Iqbal¹,

Shah²,

Sikandar³

2019

TPMJ

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Obesity is a common clinical disorder featuring excessive buildup of body fat. The bioavailability of vitamin D in obese subjects is lowered because of its sequestration in the superfluous fat tissue. Hypovitaminosis D itself is associated with glucose intolerance, insulin resistance, dyslipidemia and hypertension, which are also linked to obesity. Objectives: To compare and correlate serum vitamin D and insulin resistance in controls and overweight / obese males. Study Design: Cross Sectional, Comparative Study. Setting: The study was conducted in the Department of Physiology, Post – Graduate Medical Institute (PGMI) in collaboration with Lahore General Hospital and Central Park Medical College. Period: From 7th June 2018 to 10th Oct 2018. Material and Methods: Eighty male subjects (age range 35-50 years) included in this cross-sectional comparative study were divided into two groups on the basis of BMI; Group I: non-obese (control) BMI < 25 Kg/m2 (n=40) and Group II: overweight / obese males with BMI ˃25 Kg/m2 (n=40). Fasting serum vitamin D (25 hydroxy cholecalciferol; 25-OH D, serum insulin and blood glucose levels were measured. Insulin resistance (IR) was estimated from fasting serum glucose levels taken in mmol/l and the fasting serum insulin taken in µIU/ml by using Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR index). Results: Group II had lower serum 25-OH vitamin D levels and higher HOMA-IR index than control group. Significant negative correlation was present between serum vitamin D and HOMA-IR. Conclusion: Vitamin D deficiency may promote insulin resistance in overweight or obese individuals.

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Calcium intake, serum vitamin D and obesity in children: is there an association?

Cited by 20 publications

References 35 publications

The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study

The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study

Association between Dietary Calcium Intake and Adiposity in Male Adolescents

Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

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