Calcium Ion Treatment Behavior of Silk Fibroin/Sodium Alginate Scaffolds

Abstract

The silk fibroin/sodium alginate scaffolds were prepared using lyophilization method. And then, the blend scaffolds were treated with calcium ions. The morphology of the blend scaffolds exhibited a thin layer structure before calcium ions treatment, and much more rod-like structure appeared at the layer surface with adding the increase content of sodium alginate in the blend scaffolds. After calcium ions treatment, much more rod-like structure disappeared after adding 30% sodium alginate or more in the blend scaffolds. Wide angle X-ray diffraction and Fourier transform infrared analysis results confirmed the crystal structure of silk fibroin was not influenced by adding the different content of sodium alginate, exhibiting the silk I and silk II structure co-existed in the blend scaffolds. And the same time, the average mass loss value of the blend scaffolds was higher than the pure silk fibroin scaffold, reaching 9.884%, 11.2%, and 8.626%, respectively, when the blend scaffolds contained 10%, 30%, and 50% sodium alginate, respectively. Thus, the silk fibroin/sodium alginate scaffolds should be a useful biomaterial applicable for a wide range of tissue engineering.

Vertical 0.6 V sub-10 nm oxide-homojunction transistor gated by a silk fibroin/sodium alginate crosslinking hydrogel for pain-sensitization enhancement emulation

“…SA contains a large number of carboxyl and hydroxyl groups, resulting in high hydrophilicity and degradability. 29 Taking into these advantages, the SA is regarded as an ideal material to realize mesoscopic functionalization by introducing itself into the SF matrix. As a result, there should be strong intermolecular interactions between SF and SA, ascribing to the amide bonds formed by the amino group of SF and carbonyl group of SA.…”

“…It is mainly composed of amide I (random coils and a-helix), Amide II (b-turn structure), amide III (b-sheets), and O-H. 32 As a comparison, the peaks around 1020, 1410, 1590, and 3270 cm À1 in the SA film (blue line) were correlated to the stretching of C-O-C, -COO-(symmetric), -COO-(asymmetric), and O-H, respectively. 29 Fig. S1b (ESI †) shows the detailed group composition of SA, which is mainly composed of C-O-C, C-O, COO-, and O-H, respectively.…”

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

“…Alginate and its salts, e.g., sodium alginate (SA) are promising natural substances to use in blends with silk fibroin [ 123 ]. In recent years some articles about silk fibroin/sodium alginate materials have been published [ 123 , 124 , 125 , 126 , 127 , 128 , 129 ].…”