2016
DOI: 10.1039/c5sc03655k
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Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12

Abstract: Human S100A12 exhibits Ca(ii)-dependent Zn(ii)-binding properties and antifungal activity.

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Cited by 54 publications
(122 citation statements)
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“…1012,1417,20 Nevertheless, investigations of CP-Ser 20 as well as the host-defense proteins S100A7 34 and S100A12 35 have demonstrated that His 3 Asp sites sequester Zn(II). Moreover, studies of metal depletion from microbial growth media indicate that His 3 Asp sites select for Zn(II) over other metals, including Ni(II).…”
Section: Resultsmentioning
confidence: 99%
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“…1012,1417,20 Nevertheless, investigations of CP-Ser 20 as well as the host-defense proteins S100A7 34 and S100A12 35 have demonstrated that His 3 Asp sites sequester Zn(II). Moreover, studies of metal depletion from microbial growth media indicate that His 3 Asp sites select for Zn(II) over other metals, including Ni(II).…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, studies of metal depletion from microbial growth media indicate that His 3 Asp sites select for Zn(II) over other metals, including Ni(II). 14,34,35 We therefore sought to examine metal exchange at the His 3 Asp site using the pull-down assay described above. Efforts to purify a biotinylated His 4 variant resulted in poor yields because the protein routinely precipitated, and we were unable to readily obtain sufficient quantities of this protein for the assay.…”
Section: Resultsmentioning
confidence: 99%
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“…CP also binds Fe II with high affinity, hinting at a broader anti-bacterial function of this protein (14). S100 A7 (psoriasin) and A12 (calgranulin C) are other well studied members of this class of proteins with metal-sequestering antimicrobial activity (15,16).…”
Section: Among the Biologically Required First Row Late D-block Metamentioning
confidence: 99%
“…Human S100A12 is one such protein that harbors two His 3 Asp sites that coordinate Zn(II) with sub-nM affinity. 19–20 Moreover, S100A12 can deplete Zn(II) from microbial growth medium. 20 …”
mentioning
confidence: 99%