Calcium Is Essential for ATP-Induced Steroidogenesis in Bovine Adrenocortical Fasciculata Cells.

Niitsu, Akiyoshi

doi:10.1254/jjp.60.269

Cited by 26 publications

(21 citation statements)

References 16 publications

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“…ATP has been implicated in stimulating steroidogenesis from cortical cells of zona glomerulosa and zona fasciculata [Kawamura et al, 1991;Matsui, 1991;Niitsu, 1992;Jurá nyi et al, 1997]. The occurrence of the P2X 1 receptor subtype in the adrenal cortical cells of the zona reticularis, as found in this study of the guinea pig adrenal gland, may reflect the involvement of ATP in the activities of cells of this region as well.…”

Section: Discussionsupporting

confidence: 69%

“…It has also been shown that ATP is released from the adrenal capsule and zona glomerulosa region of the gland [Jurá nyi et al, 1997]. Functionally, ATP has been shown to stimulate steroidogenesis from the adrenal zona glomerulosa [Jurá nyi et al, 1997] and fasciculata cells [Kawamura et al, 1991;Matsui, 1991;Niitsu, 1992]. It also facilitates [Chern et al, 1988;Kim and Westhead, 1989] and inhibits [Chern et al, 1987] catecholamine secretion from adrenal chromaffin cells.…”

Section: Introductionmentioning

confidence: 99%

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Localization of P2X Receptors in the Guinea Pig Adrenal Gland

Afework

Burnstock²

2000

Cells Tissues Organs

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The distribution of each of the seven subtypes of adenosine 5′-triphosphate (ATP)-gated P2X receptors was investigated in the adrenal gland of guinea pig utilizing immunohistochemical techniques. The occurrence of positive immunoreactivity with specific distribution was observed for antibodies against P2X₁, P2X₂, P2X₅ and P2X₆ receptors, whereas no immunoreactivity was found for antibodies against P2X₃, P2X₄ and P2X₇ receptors. Immunoreactivity for P2X₁ occurred in cells of the inner region of the zona reticularis of the cortex, Several P2X₂-immunoreactive connective tissue-like elements were located between groups of cortical cells of the zona reticularis. Bundles and terminals of nerve fibres as well as intrinsic neurones gave positive immunoreactivity for P2X₅. The immunoreactive nerve fibres appeared to belong to both extrinsic preganglionic sympathetic and intrinsic immunoreactive neurones. Chromaffin cells were immunoreactive for the P2X₆ receptor antibody. The widespread and specific distribution of P2X receptor subtypes in the adrenal gland suggests significant roles for purinergic signalling in the physiology of the guinea pig adrenal gland.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Localization of P2X Receptors in the Guinea Pig Adrenal Gland

Afework

Burnstock²

2000

Cells Tissues Organs

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“…Functional studies have shown that ATP can facilitate [12,25] and inhibit [11] catecholamine secretion from adrenal chroma n cells. ATP can also stimulate steroidogenesis from adrenal cortical cells [23,24,27,30]. These observations suggest that ATP receptors located on the adrenal gland cells play important physiological roles in the activity of the gland.…”

Section: Introductionmentioning

confidence: 86%

Age‐related changes in the localization of P2X (nucleotide) receptors in the rat adrenal gland

Afework¹,

Burnstock

2000

Intl J of Devlp Neuroscience

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Observation of the changes in the occurrence and distribution of nucleotide (P2X) receptors in the adrenal gland during development and ageing, and correlation with the changes in adrenal status at similar stages may give morphological insights into the functions of purine nucleotides in the gland. Age-related changes in the localization of all seven subtypes of the P2X receptor in the adrenal gland of rat were therefore investigated immunohistochemically. In the adrenal glands of prenatal rats, immunoreactivity to P2X receptor subtypes was not observed. In glands of the postnatal rat at the developmental stages studied, only immunoreactivity for the P2X 5 receptor subtype was observed. A small number of faintly P2X 5 -immunoreactive chroma n cells were found in the adrenal glands of 1-day-old rats; the frequency of localization and intensity of staining of immunoreactive cells had increased by day 4 and was further increased at day 7. P2X 5 immunoreactivity was not observed in the adrenal glands from 14-and 21-day-old rats. At 8 weeks of age, immunoreactivity with a speci®c distribution for each of the seven receptor subtypes was observed. Except for the P2X 4 receptor, adrenal glands at 24 months showed a similar pattern of immunoreactivity for the receptor subtypes as that observed at 8 weeks. Immunoreactivity for P2X 4 was ®rst observed in the adrenal cortical cells of the zona reticularis at 8 weeks, but was absent in 24-month-old rats. However, several P2X 4 -immunoreactive chroma n cells appeared at 24 months. Such immunoreactive cells were not seen in rats of any of the other ages studied. It was concluded that the greater expression of P2X 5 receptor at an early developmental stage and of P2X 4 in ageing might re¯ect functional roles for purines in cellular proliferation and/or di erentiation, and in cellular degeneration, respectively, in adrenal glands of rat. 7

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“…(Matsui 1991) and facilitates steroidogenesis via P2Y receptors (Kawamura et al 1991), which is not inhibited by dihydropyridine (Niitsu 1992). Therefore ATP-induced steroidogenesis might be activated by capacitative Ca 2+ entry.…”

Section: Znmentioning

confidence: 98%

“…We also reported that extracellular adenosine 5 -triphosphate (ATP) facilitates steroidogenesis in BAFC via P2Y receptors (Kawamura et al 1991). Niitsu (1992) (Berridge 1995). Gq protein-coupled receptor agonists stimulate inositol 1,4,5-trisphosphate (IP 3 ) production and subsequent Ca 2+ release from intracellular stores.…”

Section: Introductionmentioning

confidence: 99%