Calcium Metabolism in Health and Disease

Peacock, Munro

doi:10.2215/cjn.05910809

Cited by 691 publications

(561 citation statements)

References 51 publications

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“…Suboptimal calcium and magnesium dietary intake increases the risk of cardiovascular disease (CVD), insulin resistance, type 2 diabetes, hypertension and osteoporosis [31,34]. Additionally, high dietary phosphorus intake increases the risk of CVD in subjects with normal kidney function and causes hormonal disturbances related to bone health [10].…”

Section: Introductionmentioning

confidence: 99%

Calcium, magnesium and phosphorus dietary intake in active and sedentary Polish students

Malara

Tkaczyk

Kęska

et al. 2017

Biomedical Human Kinetics

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SummaryStudy aim: To evaluate energy, macronutrient, calcium, magnesium, and phosphate daily intake in young healthy Polish male students. Material and methods: Two hundred and sixteen participants were physical education students engaged in regular physical activity (about 9 h/week) and were recognized as physically active. One hundred and fourteen students were from other specializations participating in 1.5 h/week gymnastics classes and were recognized as sedentary. Body mass and height were measured using standard medical equipment. Body fat was evaluated from four skinfold measurements. In all subjects daily intake of energy, protein, fat, carbohydrates, calcium, magnesium and phosphate was briefly assessed from 24-hour food records taken over 4 days. Results: The active students' diet was characterized by significantly higher energy, macronutrient and mineral daily intake. Moreover, calcium to phosphorus and calcium to magnesium ratios in active subjects were higher than in sedentary ones. There was no significant difference between groups in protein or magnesium intake expressed per 1000 kcal. In contrast, daily intake of fat and phosphate expressed per 1000 kcal was significantly lower in the active students vs. sedentary ones (p < 0.001 and p < 0.05 for fat and phosphate, respectively). Active students were characterized by significantly higher carbohydrate and calcium intake per 1000 kcal in comparison with their sedentary counterparts (p < 0.001 for both variables). Conclusions:The dietary pattern of active students was found to be slightly but significantly better than that of their sedentary counterparts. However, in both groups it was far from being a healthy one.

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Section: Introductionmentioning

confidence: 99%

Calcium, magnesium and phosphorus dietary intake in active and sedentary Polish students

Malara

Tkaczyk

Kęska

et al. 2017

Biomedical Human Kinetics

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“…HP is a rare disease, with an estimated prevalence of 37 cases per 100,000 inhabitants in the USA (3). In Brazil, studies about the disease itself and data about its epidemiology are lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Its mechanism of action includes stimulation of bone remodeling with release of calcium and phosphate from the skeleton, and stimulation of the 1α-renal hydroxylase -an essential enzyme for production of calcitriol, which is the active form of vitamin D and therefore important for calcium absorption and bone resorption. In addition, PTH stimulates calcium reabsorption and phosphate secretion in renal tubular cells (1,3,4).…”

Section: Introductionmentioning

confidence: 99%

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Lopes

Kliemann

Bini

et al. 2016

Arch. Endocrinol. Metab.

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Objectives: To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods: Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results: Fiftyfive patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). Conclusions: The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism. Arch Endocrinol Metab. 2016;60(6):532-6

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“…It is widely known that chronic and severe vitamin D deficiency impairs calcium and phosphorus absorption leading to disturbances in bone mineralization. Slight vitamin D insufficiency has been associated with inability to reach a proper peak bone mass and/or to maintain skeletal homeostasis (6). The impact of other nutritional deficiencies on bone health is not well established.…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density in short bowel syndrome: correlation with BMI and serum vitamins C, E and K

Braga

Bizari

Suen

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Bone loss has been established as a major extra-intestinal complication of short bowel syndrome (SBS). The purpose of this study was to correlate bone mineral density (BMD) with body mass index (BMI), serum vitamin and mineral levels in patients with SBS. Material and methods: The study was conducted on 13 patients (8 male and 5 female, 54.7 ± 11.4 years) with SBS (residual small bowel length of 10 to 100 cm). We determined the food ingestion, anthropometry, serum levels of vitamins C, A, D, E and K, as well as serum and urinary levels of phosphorus and calcium. BMD was measured by dual-energy x-ray absorptiometry (DXA). Results: Osteopenia and osteoporosis was diagnosed in all but one SBS patient. Serum levels of vitamin D were low in all volunteers. Sixty-one percent of patients had vitamin E deficiency; hypovitaminosis A and C occurred in one subject. BMI and C, E and K vitamin serum levels correlated with T-score of BMD. Conclusions: Osteopenia and osteoporosis were common in SBS patients. There was a correlation between BMD and the serum levels of vitamins C, E and K, an indicative that such vitamins may influence bone health. Arch Endocrinol Metab. 2015;59(3):252-8

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Calcium Metabolism in Health and Disease

Cited by 691 publications

References 51 publications

Calcium, magnesium and phosphorus dietary intake in active and sedentary Polish students

Calcium, magnesium and phosphorus dietary intake in active and sedentary Polish students

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Bone mineral density in short bowel syndrome: correlation with BMI and serum vitamins C, E and K

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