Calcium Orthophosphate-Based Bioceramics and Its Clinical Applications

Dorozhkin, Sergey V.

doi:10.1007/978-3-319-56059-5_5

Cited by 12 publications

(7 citation statements)

References 873 publications

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“…Of the approved products for Korean dental alloplastic bone substitute, seven products that consist with TCP were commercialization. BoneSigma TCP (SigmaGraft, Fullerton, CA, USA) has been described as one of the in vitro studies27, and clinically available products2829 but no clinical studies have been published. Excelos is registered as β-TCP etc.…”

Section: Resultsmentioning

confidence: 99%

Dental alloplastic bone substitutes currently available in Korea

Hong

Lee

et al. 2019

J Korean Assoc Oral Maxillofac Surg

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As dental implant surgery and bone grafts were widely operated in Korean dentist, many bone substitutes are commercially available, currently. For commercially used in Korea, all bone substitutes are firstly evaluated by the Ministry of Health and Welfare (MOHW) for safety and efficacy of the product. After being priced, classified, and registration by the Health Insurance Review and Assessment Service (HIRA), the post-application management is obligatory for the manufacturer (or representative importer) to receive a certificate of Good Manufacturing Practice by Ministry of Food and Drug Safety. Currently, bone substitutes are broadly classified into C group (bone union and fracture fixation), T group (human tissue), L group (general and dental material) and non-insurance material group in MOHW notification No. 2018-248. Among them, bone substitutes classified as dental materials (L7) are divided as xenograft and alloplastic bone graft. The purpose of this paper is to analyze alloplastic bone substitutes of 37 products in MOHW notification No. 2018-248 and to evaluate the reference level based on the ISI Web of Knowledge, PubMed, EMBASE (1980–2019), Cochrane Database, and Google Scholar using the criteria of registered or trademarked product name.

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Section: Resultsmentioning

confidence: 99%

Dental alloplastic bone substitutes currently available in Korea

Hong

Lee

et al. 2019

J Korean Assoc Oral Maxillofac Surg

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“…Em vez disso, os dispositivos constituídos por materiais que haviam sido sintetizados e fabricados para várias necessidades industriais foram testados de uma forma de tentativa e erro in vivo em animais e em humanos. Essas tentativas não planejadas e esporádicas tiveram, de certa forma, um sucesso modesto (Dorozhkin, 2017). Os biomateriais desenvolvidos durante o período 1960-1980 atraíram muito interesse devido ao seu potencial de substituir estruturas anatômicas danificadas ou ausentes por um sintético inerte.…”

Section: Introductionunclassified

Obtenção de hidroxiapatita por reação de combustão da solução para aplicações biomédicas

Batista¹,

Oliveira²,

Ponciano³

et al. 2022

Novas Tecnologias Aplicadas À Engenharia Biomédica: Uma Contribuição À Engenharia De Tecidos

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

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“…Because of the above drawbacks, there is still an increasing demand for synthetic bone material as a substitute to natural bone, including metals [24], polymers [13,14], and bioceramics (such as calcium phosphate, calcium sulphate, b-tricalcium phosphate, and HAp powders, granules, or porous blocks), also acting as a carrier for drug or gene delivery [18,[25][26][27]. Among them, calcium orthophosphate ceramics, particularly HA, have attracted significant attention due to their excellent biological behavior, such as biocompatibility, bioactivity, and osteoconductivity.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of Differently Nanostructured and High-Pressure Compressed Hydroxyapatite-Based Materials for Bone Tissue Regeneration

et al. 2021

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Hydroxyapatite (HAp) has long been considered the gold standard in the biomedical field, considering its composition and close resemblance to human bone. However, the brittle nature of hydroxyapatite (HAp) biomaterial, constrained by its low fracture toughness (of up to 1.2 vs. 2–12 MPa m1/2 of human bone), remains one of the significant factors impairing its use in bone regeneration. In the present study, HAp nanoparticles synthesized by the solid-state (SHAp) and sonochemical (EHAp) approaches using eggshell-derived calcium hydroxide and ammonium dihydrogen orthophosphate as precursors are compared with those synthesized using commercially available calcium hydroxide and ammonium dihydrogen orthophosphate as precursors (CHAp) employing sonochemical method. The HAp samples were then compressed into compact materials using a uniaxial high-pressure compression technique at a preoptimized load and subsequently characterized for mechanical properties using the Vickers indentation method and compressive strength testing. The analysis revealed that the material with smaller particle size (30–40 nm) and crystalline nature (EHAp and CHAp) resulted in mechanically robust materials (σm= 54.53 MPa and 47.72 MPa) with high elastic modulus (E = 4011.1 MPa and 2750.25 MPa) and density/hardness-dependent fracture toughness (σf= 4.34 MPa m1/2and 6.57 MPa m1/2) than SHAp (σm =28.40 MPa, E = 2116.75 MPa, σf = 5.39 MPa m1/2). The CHAp material was found to be the most suitable for applications in bone regeneration.

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Calcium Orthophosphate-Based Bioceramics and Its Clinical Applications

Cited by 12 publications

References 873 publications

Dental alloplastic bone substitutes currently available in Korea

Dental alloplastic bone substitutes currently available in Korea

Obtenção de hidroxiapatita por reação de combustão da solução para aplicações biomédicas

Mechanical Properties of Differently Nanostructured and High-Pressure Compressed Hydroxyapatite-Based Materials for Bone Tissue Regeneration

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