Calcium orthophosphates as a dental regenerative material

Dorozhkin, Sergey V.

doi:10.1016/b978-0-08-102476-8.00016-5

Cited by 4 publications

(4 citation statements)

References 505 publications

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“…In our study there was no complications reported by the patients after the experiment. Similar results were obtained and no complications were observed by other studies as well 21 .…”

Section: Discussionsupporting

confidence: 92%

Efficacy of Calcium Phosphate Composite Bone Graft in Treatment of Periodontal Intrabony Defects: Clinico-Radiographic Study

Shirazi¹,

Ali²,

Aminwala³

et al. 2022

PJMHS

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Background: The loss of alveolar bone support is the main symptoms of the destructive periodontal disease. Periodontitis leads to formation of the interbony defects. For resolution of the infection, the elimination of IBD is highly needed. For the filing of the IBD and regeneration of the bone in the periodontal therapy, different bone grafts are used. Objective: The study aimed to evaluate the efficacy of calcium phosphate composite bone graft in patients suffering from periodontal intrabony problems. Study Design: It is a randomized and interventional study conducted at Multan Medical & Dental College, Multan and DOW University of Health Sciences, Karachi for the duration of six months from December 2021 to May 2022. Material and Methods: The study was conducted on 16 patients that fulfilled the inclusion criteria. All the patients completed the follow-up. The radiographic parameters were also evaluated. The baseline data from six months and three months was analyzed and data was plotted. Results: It was found that the primary closure was carried out for all the patients. There was no statistical significance found between the groups related to depth of the defect and the walls number groups before operation. There was a prominent reduction in plague concentration and gingival index. In case of test group there was a greater statistical reduction in the test group as compared to the control. The recession of gingival parameter was seen in both the groups. There was no statistical difference observed here. Conclusion This study helps to provide significant results and evidence that the easy graft crystal can be used for the treatment of periodontal intrabony issues. Keywords: Intrabony defects and calcium phosphate composite bone graft.

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“…In our study there was no complications reported by the patients after the experiment. Similar results were obtained and no complications were observed by other studies as well 21 .…”

Section: Discussionsupporting

confidence: 92%

Efficacy of Calcium Phosphate Composite Bone Graft in Treatment of Periodontal Intrabony Defects: Clinico-Radiographic Study

Shirazi¹,

Ali²,

Aminwala³

et al. 2022

PJMHS

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“…Previous studies have incorporated monocalcium phosphate monohydrate (MCPM; 10-40 wt %) into dental composites to promote mineralizing actions for the materials [9][10][11][12][13]. MCPM is a commercially available calcium phosphate compound with excellent ion-releasing and hydroxyapatite formation abilities [14]. Previous studies showed that an increase in MCPM (from 10 to 40 wt %) reduced the flexural strength of the composite [15].…”

Section: Introductionmentioning

confidence: 99%

Physical/Mechanical and Antibacterial Properties of Orthodontic Adhesives Containing Calcium Phosphate and Nisin

Chanachai

Chaichana

Insee

et al. 2021

JFB

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Enamel demineralization around orthodontic adhesive is a common esthetic concern during orthodontic treatment. The aim of this study was to prepare orthodontic adhesives containing monocalcium phosphate monohydrate (MCPM) and nisin to enable mineralizing and antibacterial actions. The physicomechanical properties and the inhibition of S. mutans growth of the adhesives with added MCPM (5, 10 wt %) and nisin (5, 10 wt %) were examined. Transbond XT (Trans) was used as the commercial comparison. The adhesive containing a low level of MCPM showed significantly higher monomer conversion (42–62%) than Trans (38%) (p < 0.05). Materials with additives showed lower monomer conversion (p < 0.05), biaxial flexural strength (p < 0.05), and shear bond strength to enamel than those of a control. Additives increased water sorption and solubility of the experimental materials. The addition of MCPM encouraged Ca and P ion release, and the precipitation of calcium phosphate at the bonding interface. The growth of S. mutans in all the groups was comparable (p > 0.05). In conclusion, experimental orthodontic adhesives with additives showed comparable conversion but lesser mechanical properties than the commercial material. The materials showed no antibacterial action, but exhibited ion release and calcium phosphate precipitation. These properties may promote remineralization of the demineralized enamel.

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“…Although the formation of human dental enamel is a result of cellular and chemical processes [1], the cell-assisted (xenogenic and stem cells) hard tissue remineralization is rather complicated [1,12], so that cell-free solutions are preferred. Protein [14,15] and protein analogues [16][17][18][19] were used to obtain extracellular environments guiding the construction of enamel-like apatite layers on the surface of enamel lesions [1,12]. However, natural proteins such as commercially available EmdogainR (EMD) extracted from porcine teeth [18] are difficult to obtain.…”

Section: Introductionmentioning

confidence: 99%

“…Protein [14,15] and protein analogues [16][17][18][19] were used to obtain extracellular environments guiding the construction of enamel-like apatite layers on the surface of enamel lesions [1,12]. However, natural proteins such as commercially available EmdogainR (EMD) extracted from porcine teeth [18] are difficult to obtain. Peptides and oligopeptides are known as protein analogues providing scaffolds for HAP nucleation and promoting the remineralization of dental enamel [9,11,16,17].…”

Section: Introductionmentioning

confidence: 99%

A Chitosan–Agarose Polysaccharide-Based Hydrogel for Biomimetic Remineralization of Dental Enamel

et al. 2021

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Developing multifunctional systems for the biomimetic remineralization of human enamel is a challenging task, since hydroxyapatite (HAP) rod structures of tooth enamel are difficult to replicate artificially. The paper presents the first report on the simultaneous use of chitosan (CS) and agarose (A) in a biopolymer-based hydrogel for the biomimetic remineralization of an acid-etched native enamel surface during 4–10-day immersion in artificial saliva with or without (control group) fluoride. Scanning electron microscopy coupled with energy-dispersive X-ray spectrometry, Fourier transform infrared and Raman spectroscopies, X-ray diffraction, and microhardness tests were applied to investigate the properties of the acid-etched and remineralized dental enamel layers under A and CS-A hydrogels. The results show that all biomimetic epitaxial reconstructed layers consist mostly of a similar hierarchical HAP structure to the native enamel from nano- to microscale. An analogous Ca/P ratio (1.64) to natural tooth enamel and microhardness recovery of 77.4% of the enamel-like layer are obtained by a 7-day remineralization process in artificial saliva under CS-A hydrogels. The CS component reduced carbonation and moderated the formation of HAP nanorods in addition to providing an extracellular matrix to support growing enamel-like structures. Such activity lacked in samples exposed to A-hydrogel only. These data suggest the potential of the CS-A hydrogel in guiding the formation of hard tissues as dental enamel.

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Calcium orthophosphates as a dental regenerative material

Cited by 4 publications

References 505 publications

Efficacy of Calcium Phosphate Composite Bone Graft in Treatment of Periodontal Intrabony Defects: Clinico-Radiographic Study

Efficacy of Calcium Phosphate Composite Bone Graft in Treatment of Periodontal Intrabony Defects: Clinico-Radiographic Study

Physical/Mechanical and Antibacterial Properties of Orthodontic Adhesives Containing Calcium Phosphate and Nisin

A Chitosan–Agarose Polysaccharide-Based Hydrogel for Biomimetic Remineralization of Dental Enamel

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