Calcium Oxalate Crystals in the Breast

Gonzalez, J E; Caldwell, Reece; Valaitis, Jonas

doi:10.1097/00000478-199106000-00007

Cited by 50 publications

(35 citation statements)

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“…The crystals are typically within benign cysts or terminal ductules, exhibiting apocrine differentiation by conventional morphologic criteria or by immunoreactivity to monoclonal antibodies against gross cystic disease fluid protein with 1,500 molecular weight (anti-GCDFP-15). 8 However, breast tissue away from the areas with CaOx display a morphologic spectrum roughly similar to that in cases of CaP only. Since CaOx in breast biopsies is often clinically significant and CaOx is not clearly visible in routine sections, examination under polarized light is suggested for all breast biopsies removed for mammographically visible calcifications, particularly when CaP deposits corresponding to the mammographic calcifications are not apparent.…”

Section: öZer Et Almentioning

confidence: 94%

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Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Özer

Canda²,

Balci³

et al. 1999

Acta Cytologica

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Section: öZer Et Almentioning

confidence: 94%

“…CaOx in breast cyst fluid should be regarded as a particular type of calcification, easily overlooked with conventional light microscopy. 8,10 This may explain radiologicpathologic discrepancies in descriptions of microcalcifications. In such instances the crystals are readily detected by their birefringence in cytologic specimens.…”

mentioning

confidence: 99%

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Özer

Canda²,

Balci³

et al. 1999

Acta Cytologica

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“…Distinguishing between calcium oxalate and calcium phosphate is clinically important. Specifically, it is uncommon for calcium oxalate crystals to be associated with breast malignancy, 45,46 though it can be associated with papillary intraductal carcinoma. 47 Calcium oxalate crystals account for 12% of mammographically localized calcifications that typically prompt for a biopsy procedure.…”

Section: Detection Of Microcalcifications In Breast Biopsiesmentioning

confidence: 99%

Tissue refractive index as marker of disease

et al. 2011

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Abstract. The gold standard in histopathology relies on manual investigation of stained tissue biopsies. A sensitive and quantitative method for in situ tissue specimen inspection is highly desirable, as it would allow early disease diagnosis and automatic screening. Here we demonstrate that quantitative phase imaging of entire unstained biopsies has the potential to fulfill this requirement. Our data indicates that the refractive index distribution of histopathology slides, which contains information about the molecular scale organization of tissue, reveals prostate tumors and breast calcifications. These optical maps report on subtle, nanoscale morphological properties of tissues and cells that cannot be recovered by common stains, including hematoxylin and eosin. We found that cancer progression significantly alters the tissue organization, as exhibited by consistently higher refractive index variance in prostate tumors versus normal regions. Furthermore, using the quantitative phase information, we obtained the spatially resolved scattering mean free path and anisotropy factor g for entire biopsies and demonstrated their direct correlation with tumor presence. In essence, our results show that the tissue refractive index reports on the nanoscale tissue architecture and, in principle, can be used as an intrinsic marker for cancer diagnosis. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…The characteristics of the mineral deposits isolated from tissues may help diagnose the cause of the disease and determine the developmental stage of the focus. Notably, some typical mineral deposits have become an auxiliary sign for malignant tumor diagnosis (Frappart et al, 1984;Gonzalez et al, 1991;Fandos -Morera et al, 1988;Lanyi, 1985;Sorbe and Frankendal, 1982). However, the significance of the mineral deposits in pathological tissues and their potential use as indicators for the stage of disease have not yet been fully explored or understood, especially not from the viewpoint of mineralogy.…”

Section: Introductionmentioning

confidence: 99%

A study on psammoma body mineralization in meningiomas

Wang

Yang

et al. 2011

Journal of Mineralogical and Petrological Sciences

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Psammoma bodies (PBs) in meningioma patients often contain mineral deposits. In this paper, the mineralogical characteristics of PBs in the mineralized focus in meningioma patients were investigated by using scanning electron microscopy (SEM), environmental scanning electron microscopy (ESEM), high -resolution transmission electron microscopy (HRTEM), energy dispersive X -ray analysis (EDAX), and electron probe microanalysis (EPMA). We found that PBs had a concentric layered structure and the size ranged from several to tens of micrometers. Although no obvious trend in the variation of Ca/P ratios was observed from the center to the outer edge of the PBs, the Ca/P ratios were much lower in the early stage of PBs formation. The concentric layered structure of the PBs might be formed by a spiral arrangement of mineralized collagen fibers. Studies on PBs mineralization may provide some supporting information in understanding the origin and development of meningiomas.

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Calcium Oxalate Crystals in the Breast

Cited by 50 publications

References 0 publications

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Tissue refractive index as marker of disease

A study on psammoma body mineralization in meningiomas

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