Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery

Günter, Elena A.; Popeyko, Oxana V.

doi:10.1016/j.carbpol.2016.04.026

Cited by 74 publications

(35 citation statements)

References 35 publications

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“…For example, Gebara and others () have also reported complete disintegration of pectin microparticles coated with whey protein at pH 7.0. This disintegration is related to the dissociation of pectin‐chitosan polyelectrolyte complex coating (Birch and Schiffman ) as well as calcium pectinate gel (Günter and Popeyko ) under these pH conditions.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of Lactobacillus casei into Calcium Pectinate‐Chitosan Beads for Enteric Delivery

Bepeyeva

Barros

Albadran

et al. 2017

Journal of Food Science

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Section: Resultsmentioning

confidence: 99%

Encapsulation of Lactobacillus casei into Calcium Pectinate‐Chitosan Beads for Enteric Delivery

Bepeyeva

Barros

Albadran

et al. 2017

Journal of Food Science

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“…Low methoxylated pectins, such as AP, tanacetan, lemnan, and silenan, form gels in the presence of calcium ions, and pectin molecules are cross-linked by calcium ions. (21) For comparison, MPA and MA, the standard media for the cultivation of bacteria, were used as solid media. The ability of solid media to modulate the formation of E. coli biofilms was evaluated by the number of CFU.…”

Section: Resultsmentioning

confidence: 99%

The Study of the Growth of Escherichia coli on Pectins

Shubakov¹,

Mikhailova²

2019

IJBM

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The growth of E. coli on pectins isolated from various plant sources was studied. We used commercial apple pectin AU701 and low-methyl esterified pectins (6-22%) from callus cultures of tansy Tanacetum vulgare L. (TV, tanacetan), duckweed Lemna minor L. (LM, lemnan), and campion Silene vulgaris (M.) G. (SV, silenan). Bacterial growth was also tested on the enzymatic degradation products of tanacetan pectin. For comparison, bacterial growth was studied on easily metabolizable carbon sources-glucose and lactose. E. coli was cultivated on solid media in Petri dishes and in liquid nutrient media in Erlenmeyer flasks at a temperature of +37°C and at room temperature. It was found that E. coli colonies do not form with growth on gels of tanacetan, lemnan and silenan. When growing on a gel of apple pectin, a weak bacterial growth is detected. However, E. coli is capable of growth on soluble products of enzymatic hydrolysis of tanacetan pectin-oligogalacturonides.

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“…It can be assumed that the differences in the stability of HPGPs formed from different pectins are associated with differences in molecular sizes and in the fine structure of pectic macromolecules. (1,2) The obtained data may indicate the prospect of further studies of the properties of hyaluronan-pectic gels, the microparticles of which can be tested as directed drug delivery systems in the small and large intestine. Statistics F=1273.0453 P=0.0000 P 1-2 =0.0000 P 1-3 =0.0000 P 1-4 =0.0000 P 2-3 =0.0000 P 2-4 =0.0000 P 3-4 =0.0000…”

Section: Resultsmentioning

confidence: 99%

Stability of Hyaluronan-Pectic Gel Particles in the Conditions of the Artificial Gastrointestinal Environment

Mikhailova¹,

Melekhin²,

Belyy³

et al. 2017

IJBM

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Spherical hyaluronan-pectic gel particles (HPGPs) from hyaluronic acid (HA) and low-methyl esterified pectins of callus cultures of tansy, duckweed, campion and commercial apple pectin were obtained by the method of ionotropic gelation in the presence of calcium ions. We investigated the morphology, swelling and degradation of the obtained HPGPs in the conditions of a simulated gastrointestinal environment and established that the greatest stability in the artificial environment of the digestive tract is achieved with HPGPs obtained from the pectin of tansy callus cultures. HPGPs can be used as potential carriers for drug delivery systems in parts of the small and large intestine.(International Journal of Biomedicine. 2017;7(4):310-314.)

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Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery

Cited by 74 publications

References 35 publications

Encapsulation of Lactobacillus casei into Calcium Pectinate‐Chitosan Beads for Enteric Delivery

Encapsulation of Lactobacillus casei into Calcium Pectinate‐Chitosan Beads for Enteric Delivery

The Study of the Growth of Escherichia coli on Pectins

Stability of Hyaluronan-Pectic Gel Particles in the Conditions of the Artificial Gastrointestinal Environment

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