Calcium phosphate–calcium titanate composite coatings for orthopedic applications

Arce, Johanna Esguerra; Arce, Adriana Esguerra; Aguilar, Y.; Yate, Luis; Moya, Sergio; Rincón, C.; Gutierrez, O.

doi:10.1016/j.ceramint.2016.02.177

Cited by 31 publications

(12 citation statements)

References 46 publications

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“…3). These findings are consistent with recent results from our lab integrating polymeric fibers structures fabricated via 3D printing into collagen scaffolds to increase compressive or tensile properties (Mozdzen et al, 2016;Mozdzen et al, 2017;Weisgerber et al, 2016a) and is consistent with a larger attempt at forming bioactive nano-scale or micro-scale composites for tissue engineering applications (Arce et al, 2016;Sethu et al, 2017;Xing et al, 2017;Yang et al, 2015). A critical advance associated with this work is demonstrating an approach to render the composite shapefitting.…”

Section: Discussionsupporting

confidence: 91%

Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells

Dewey

Johnson

Weisgerber

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

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Craniomaxillofacial bone defects can occur as a result of congenital, post-oncologic, and highenergy impact conditions. The scale and irregularity of such defects motivate new biomaterials to promote regeneration of the damaged bone. We have recently described a mineralized collagen scaffold capable of instructing stem cell osteogenic differentiation and new bone infill in the absence of traditional osteogenic supplements. Herein, we report the integration of a millimeterscale reinforcing poly (lactic acid) frame fabricated via 3D-printing into the mineralized collagen scaffold with micron-scale porosity to form a multi-scale mineralized collagen-PLA composite. We describe modifications to the PLA frame design to increase the compressive strength (Young's Modulus, ultimate stress and strain) of the composite. A critical challenge beyond increasing the compressive strength of the collagen scaffold is addressing challenges inherent with the irregularity of clinical defects. As a result, we examined the potential for modifying the frame architecture to render the composite with increased compressive strength in one axis or radial compressibility and shape-fitting capacity in an orthogonal axis. A library of mineralized collagen-PLA composites was mechanically characterized via compression testing and push-out test to describe mechanical performance and shape-fitting capacity. We also report in vitro comparison of the bioactivity of porcine adipose derived stem cells in the mineralized collagen-PLA composite versus the mineralized collagen scaffold via metabolic activity, gene expression, and functional matrix synthesis. The results suggest that incorporation of the PLA reinforcing frame does not negatively influence the osteoinductive nature of the mineralized collagen scaffold. Together, these

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Section: Discussionsupporting

confidence: 91%

Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells

Dewey

Johnson

Weisgerber

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

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“…The incorporation of zirconia has also been shown to form favourable mechanical and bioactive properties [ 519 ]. Incorporation of other inorganic materials, for example calcium titanate, has also been shown to improve mechanical strength as well as bioactivity [ 520 ]. Similarly to scaffolds and cements, coatings are also vastly combined with polymers.…”

Section: Composite Calcium Phosphatesmentioning

confidence: 99%

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

2017

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Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs.

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“…Coating of calcium phosphate is mainly performed using sol-gel and electrodeposition methods [136, 137]. Research on calcium phosphate coatings is mainly conducted for metal implant applications, aiming to prevent implant corrosion and increase bioactivity [138, 139]. Xu et al [140] investigated porous and net-like calcium phosphate (CaHPO 4 ·2H 2 O) layers coated on a magnesium alloy surface.…”

Section: Applications Of Calcium Phosphatementioning

confidence: 99%

Bioactive calcium phosphate materials and applications in bone regeneration

et al. 2019

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BackgroundBone regeneration involves various complex biological processes. Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. It can be directly contributed to bone regeneration process or assist in the use of other biomaterials. Therefore, it is widely used in many applications and has been continuously studied.MainbodyCalcium phosphate has been widely used in bone regeneration applications because it shows osteoconductive and in some cases osteoinductive features. The release of calcium and phosphorus ions regulates the activation of osteoblasts and osteoclasts to facilitate bone regeneration. The control of surface properties and porosity of calcium phosphate affects cell/protein adhesion and growth and regulates bone mineral formation. Properties affecting bioactivity vary depending on the types of calcium phosphates such as HAP, TCP and can be utilized in various applications because of differences in ion release, solubility, stability, and mechanical strength. In order to make use of these properties, different calcium phosphates have been used together or mixed with other materials to complement their disadvantages and to highlight their advantages. Calcium phosphate has been utilized to improve bone regeneration in ways such as increasing osteoconductivity for bone ingrowth, enhancing osteoinductivity for bone mineralization with ion release control, and encapsulating drugs or growth factors.ConclusionCalcium phosphate has been used for bone regeneration in various forms such as coating, cement and scaffold based on its unique bioactive properties and bone regeneration effectiveness. Additionally, several studies have been actively carried out to improve the efficacy of calcium phosphate in combination with various healing agents. By summarizing the properties of calcium phosphate and its research direction, we hope that calcium phosphate can contribute to the clinical treatment approach for bone defect and disease.

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Calcium phosphate–calcium titanate composite coatings for orthopedic applications

Cited by 31 publications

References 46 publications

Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells

Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

Bioactive calcium phosphate materials and applications in bone regeneration

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