Calcium phosphate cements: study of the β-tricalcium phosphate — monocalcium phosphate system

Mirtchi, A A; Lemaître, Jean-Pierre; Terao, Nobuzo

doi:10.1016/0142-9612(89)90089-6

Cited by 252 publications

(157 citation statements)

References 7 publications

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“…This was an original and interesting final composition that can be compared to the brushite-type calcium phosphate cement setting reaction which produces DCPD [3]. The final composition of (Ar+Br) cement associating mostly DCPD and aragonite which have a higher solubility than PCA, probably infers a high biodegradation rate along with less acid release than for brushite calcium phosphate cements.…”

Section: Caco 3 -Cap Mixed Cement Compositionsmentioning

confidence: 99%

“…Fast-setting CaP bone cements have been studied in depth and developed in the last few years essentially as bone filling and bone reinforcement biomaterials due to their excellent biocompatibility and bioactivity. However, even though they can perfectly fill a bone cavity and be shaped as desired [2][3][4][5][6][7][8][9][10], one of the main concerns of surgeons is to reach higher rates of resorption, an improvement of bone reconstruction and to a lesser extent higher mechanical resistance [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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Section: Caco 3 -Cap Mixed Cement Compositionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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“…A blend proposed by Lema < î tre et al, [173,174] is another example of the acid-base interaction in which β-TCP (almost neutral) reacts with MCPM (acidic) to form DCPD (slightly acidic):…”

Section: General Information and Knowledgementioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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“…The starting materials for brushite cements is normally betatri-calcium phosphate (β-TCP) mixed either with monocalcium phosphate monohydrate (MCPM) [12] or phosphoric acid [13]. The starting powders are all stable at room temperature, and are therefore cheaper to produce than the metastable phases used as starting powders for HA cements.…”

Section: Introductionmentioning

confidence: 99%

Development of a Resorbable Calcium Phosphate Cement with Load Bearing Capacity

2016

Bioceram Dev Appl

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Compared to cortical bone and polymeric bone cements, the mechanical properties of calcium phosphate cements are generally poor. This has resulted in them being used in non-load bearing clinical applications. The aim of this study was to investigate the possibility of producing a brushite cement with mechanical properties closer to those of cortical bone (i.e., >100 MPa in compression), i.e. with a potential to be used in load bearing applications. With a compressive strength of 74.4 (± 10.7) MPa, maximum at 91.8 MPa, the cement presented herein is comparable with the non degradable polymeric counterparts and the strongest hydroxyapatite cements, and is close in strength of cortical bone. Furthermore, it has a high injectability (>90%) and a setting time of approximately 17 minutes. A cement comprising these properties has great potential of changing the future clinical indications for calcium phosphate cements, and could potentially reduce the use of non-degradable polymeric cements.

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Calcium phosphate cements: study of the β-tricalcium phosphate — monocalcium phosphate system

Cited by 252 publications

References 7 publications

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Self-Setting Calcium Orthophosphate Formulations

Development of a Resorbable Calcium Phosphate Cement with Load Bearing Capacity

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