Calcium Phosphate Ceramic Blasting on Titanium Surface Improve Bone Ingrowth

Goyenvalle, Eric; Aguado, Eric; Cognet, Ronan; Bourges, Xavier; Daculsi, Guy

doi:10.4028/www.scientific.net/kem.361-363.1351

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Titanium and its alloys are the most common materials, comprising 70%–80% of all used materials [ 6 , 7 , 8 ]. Due to their excellent mechanical properties, corrosion resistance, and biocompatibility, these materials are used in load-bearing areas such as orthodontics, orthopedics, and gastroenterology as well as for cardiovascular and reconstructive purposes [ 5 , 6 , 9 , 10 , 11 , 12 ]. Furthermore, components made of titanium can be easily manufactured in various shapes and textures [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

et al. 2017

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The biomaterials used to maintain or replace functions in the human body consist mainly of metals, ceramics or polymers. In orthopedic surgery, metallic materials, especially titanium and its alloys, are the most common, due to their excellent mechanical properties, corrosion resistance, and biocompatibility. Aside from the established Ti6Al4V alloy, shape memory materials such as nickel-titanium (NiTi) have risen in importance, but are also discussed because of the adverse effects of nickel ions. These might be reduced by specific surface modifications. In the present in vitro study, the osteoblastic cell line MG-63 as well as primary human osteoblasts, fibroblasts, and macrophages were cultured on titanium alloys (forged Ti6Al4V, additive manufactured Ti6Al4V, NiTi, and Diamond-Like-Carbon (DLC)-coated NiTi) to verify their specific biocompatibility and inflammatory potential. Additive manufactured Ti6Al4V and NiTi revealed the highest levels of metabolic cell activity. DLC-coated NiTi appeared as a suitable surface for cell growth, showing the highest collagen production. None of the implant materials caused a strong inflammatory response. In general, no distinct cell-specific response could be observed for the materials and surface coating used. In summary, all tested titanium alloys seem to be biologically appropriate for application in orthopedic surgery.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

et al. 2017

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“…Although there is very little trace of CaPO 4 on the Ti surface (chemical analysis of the blasted surface showed that less than 1% CaPO 4 remained over the entire surface), this value seems to be sufficient to improve biocompatibility. The blasting of metallic dental implants with biphasic HA + β-TCP bioceramic powder (BCP ® surface treatment) was also developed by Anthogyr (Sallanches, France) [668]. Both techniques produce a biocompatible rough surface free of contaminants, and guarantee fast and effective osseointegration.…”

Section: Blast Coatingmentioning

confidence: 99%

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

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A The present overview describes various production techniques for biocompatible calcium orthophosphate (abbreviated as CaPO4) deposits (coatings, films and layers) on the surfaces of various types of substrates to impart the biocompatible properties for artificial bone grafts. Since, after being implanted, the grafts always interact with the surrounding biological tissues at the interfaces, their surface properties are considered critical to clinical success. Due to the limited number of materials that can be tolerated in vivo, a new specialty of surface engineering has been developed to desirably modify any unacceptable material surface characteristics while maintaining the useful bulk performance. In 1975, the development of this approach led to the emergence of a special class of artificial bone grafts, in which various mechanically stable (and thus suitable for load-bearing applications) implantable biomaterials and artificial devices were coated with CaPO4. Since then, more than 7500 papers have been published on this subject and more than 500 new publications are added annually. In this review, a comprehensive analysis of the available literature has been performed with the main goal of finding as many deposition techniques as possible and more than 60 methods (double that if all known modifications are counted) for producing CaPO4 deposits on various substrates have been systematically described. Thus, besides the introduction, general knowledge and terminology, this review consists of two unequal parts. The first (bigger) part is a comprehensive summary of the known CaPO4 deposition techniques both currently used and discontinued/underdeveloped ones with brief descriptions of their major physical and chemical principles coupled with the key process parameters (when possible) to inform readers of their existence and remind them of the unused ones. The second (smaller) part includes fleeting essays on the most important properties and current biomedical applications of the CaPO4 deposits with an indication of possible future developments.

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“…It is now possible to manufacture products made of a variety of different materials, such as ceramics, polymers, and metals. Titanium-based alloys are widely used in the field of medical implant production [ 1 ] due to their biocompatibility and good physical and mechanical properties [ 2 , 3 , 4 , 5 , 6 ]. The excellent biocompatibility of commercially pure titanium (c.p.…”

Section: Introductionmentioning

confidence: 99%

Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects

et al. 2021

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The additive manufacturing of low elastic modulus alloys that have a certain level of porosity for biomedical needs is a growing area of research. Here, we show the results of manufacturing of porous and dense samples by a laser powder bed fusion (LPBF) of Ti-Nb alloy, using two distinctive fusion strategies. The nanostructured Ti-Nb alloy powders were produced by mechanical alloying and have a nanostructured state with nanosized grains up to 90 nm. The manufactured porous samples have pronounced open porosity and advanced roughness, contrary to dense samples with a relatively smooth surface profile. The structure of both types of samples after LPBF is formed by uniaxial grains having micro- and nanosized features. The inner structure of the porous samples is comprised of an open interconnected system of pores. The volume fraction of isolated porosity is 2 vol. % and the total porosity is 20 vol. %. Cell viability was assessed in vitro for 3 and 7 days using the MG63 cell line. With longer culture periods, cells showed an increased cell density over the entire surface of a porous Ti-Nb sample. Both types of samples are not cytotoxic and could be used for further in vivo studies.

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Calcium Phosphate Ceramic Blasting on Titanium Surface Improve Bone Ingrowth

Cited by 5 publications

References 18 publications

Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects

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