Calcium phosphate coating on magnesium alloy by biomimetic method: Investigation of morphology, composition and formation process

Yang, Jingshuai; Jiao, Yanpeng; Yin, Qian; Zhang, Tao

doi:10.1007/s11706-008-0025-5

Cited by 25 publications

(10 citation statements)

References 30 publications

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“…The ion concentration ratio of Ca/P was 1.67 in the used mixture. 37,38 The samples were immersed horizontally into the solutions in the beakers that were placed in a bath at 37°C for 24 h coating. Then, all the samples were made to undergo a heat-treatment at 300°C for 2 h. Finally, the treated samples were rinsed with deionized water, dried at room temperature, and weighed.…”

Section: Methodsmentioning

confidence: 99%

In vivo biocompatibility and degradation behavior of Mg alloy coated by calcium phosphate in a rabbit model

Jun

Lee

et al. 2011

J Biomater Appl

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This study is conducted to investigate the biocompatibility and biodegradation behavior of calcium phosphate-coated Mg alloy in vivo. Calcium phosphate (Ca-P) was coated on the Mg alloy (AZ31) by a chemical process. Samples of Ca-P coated rods, the naked alloy rods, and degradable polymer as controls were implanted into the thighbone of rabbits to investigate the bone response at the early stage. The reduction in implant volume was determined by micro-computed tomography and three-dimensional reconstruction of the remaining Mg alloy segmented from the bone matrix. It was observed that the biodegradation rate of naked Mg implant is faster than that of the coated ones. The bone-implant interface was characterized in sections by scanning electron microscopy with energy-dispersive spectroscopy. Biodegradation or reaction layer was formed on the surface of Mg alloy implants and direct contact with the surrounding bone. The layer was mainly composed of Ca, P, O, and Mg. After 8 weeks of post-operation, paraffin sections were generated for histomorphologic analysis; 100% implants were fixed and no inflammation was observed. Histological analysis showed that new bone tissue is formed around the Mg implants, and no fibrous capsule was found. Blood examination showed that the biodegradation of the Mg implant caused little change to blood composition. Ca-P coating on Mg alloy substrate might be an effective method to reduce the biodegradation rate of Mg alloy in vivo and improve the surface bioactivity of Mg alloy implants.

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Section: Methodsmentioning

confidence: 99%

In vivo biocompatibility and degradation behavior of Mg alloy coated by calcium phosphate in a rabbit model

Jun

Lee

et al. 2011

J Biomater Appl

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“…The rate of biodegradation can be tuned by alkali treatment, and immersion time during the formation of CaP coating [ 17 , 18 ]. In addition, the drug release profile can be controlled by adjusting the biological degradation of CaP coating.…”

Section: Discussionmentioning

confidence: 99%

“…Otherwise, it is biocompatible, bioactive and bioresorbable [ 16 ]. The rate of degradation is controllable according to the morphology, structure and crystallinity [ 17 , 18 ]. In addition, the porous structure of biomimetic CaP coating for the drug carrier is not dependent on the use of the polymer, which is named polymer-free drug-eluting system.…”

Section: Introductionmentioning

confidence: 99%

Sirolimus-loaded CaP coating on Co-Cr alloy for drug-eluting stent

2016

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To achieve polymer-free and controllable drug-eluting system, there have been many efforts to modify the surface composition and topography of metal stent. Recently, calcium phosphate is commonly applied to metallic implants as a coating material for fast fixation and firm-implant bone attachment on the account of its demonstrated bioactive and osteoconductive properties. In the present study, the release of sirolimus could be controllable because of immobilization of sirolimus during the process of biomimetic CaP coating forming. A completely new concept is the drug carrier of biomimetic CaP coating with sirolimus for an absorbable drug eluting system, which in turn can serve as a drug reservoir. We here describe the characteristic, mechanisms and drug release in vitro of new drug-eluting system in comparison to conventional system equivalent. Nano-structured calcium phosphate (CaP) coating was formed on the cobalt–chromium (Co-Cr) alloy substrate. By immersing coated sample in solution with sirolimus (rapamycin), the sirolimus could be immobilized in the newly formed CaP layer. The morphology, composition and formation process of the coating were studied with scanning electron microscopy, energy dispersive spectrometer, X-ray diffraction and X-ray photoelectron spectroscopy. The results showed that a uniform CaP coating incorporated with sirolimus was observed on Co-Cr alloy.

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“…Calcium phosphates or its derivatives (such as hydroxyapatite and TCP) have been coated on Mg alloys to control alloy degradation and tissue integration properties since Ca and P are the major components of natural bone Wang et al 2010b;Cui et al 2008;Hiromoto and Yamamoto 2009;Wen et al 2009;Yang et al 2008Yang et al , 2009). If osteoconductive minerals quickly form on the Mg-Zn alloy at the early stage of degradation after surface modification, and the coatings remain intact for the initial 3-6 weeks, the chances for an osteointegrated interface increase after implantation.…”

Section: Bioresorbable Ceramic Coatings On Mg Alloysmentioning

confidence: 99%

Nanotechnology Enabled In situ Sensors for Monitoring Health

2011

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except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. PrefaceNanotechnology is the use of materials with at least one direction less than 100 nm, so called nanomaterials. Examples of common nanomaterials include particles, fibers, tubes, coating features, etc. all with at least one dimension less than 100 nm. Nanotechnology has already begun to revolutionize numerous science and engineering fields, including, but not limited to fabricating faster and more light-weight computers, stronger buildings (even the consideration of building an elevator from the earth to the moon), improved catalytic devices, and medicine where several nanomaterials have been FDA approved for clinical use. In medicine, numerous researchers are searching for ways to make medicine more personal, and, nanotechnology may provide the answer. Imagine the day when we can utilize sensors placed in various parts throughout the body to determine, in real-time, biological events. Moreover, imagine a day when that same device can send information from inside to outside the body to help a clinician treat a medical problem that would be diagnosed using traditional medical imaging. Lastly, imagine a day when that same device could be programmed to reverse adverse biological events to ensure a healthier, more active patient. This book will examine the role that nanomaterials are playing in the above, specifically, in designing sensors that can diagnosis and treat diseases inside the body.To introduce the reader to this exciting and fast-moving subject, this book will first provide a forward from the medical device industry concerning the importance of developing in situ sensors to diagnosis and treat diseases in ways we are currently not able to (since, after all, the best way to a fight disease or a medical problem is at the site at which it occurs, not necessarily through conventional systemic drug delivery which takes time and efficacy is lost as drugs pass through the body partially ending up at the disease location). The first chapter will then describe fundamentals of cancer and how in situ sensors are being used to treat cancer. Clearly, cancer remains one of our foremost diseases and nanotechnology-derived sensors are making much progress towards a personalized care of select cancers. The second chapter will then cover the fundamentals of how our tissues heal and how nanosensors can be used to promote tissue healing. Excessive inflammation (often leading to scar tissue growth) and infection often disrupt healing. Thus, the third chapter will cover the fundamentals of inflammation and infection a...

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Calcium phosphate coating on magnesium alloy by biomimetic method: Investigation of morphology, composition and formation process

Cited by 25 publications

References 30 publications

In vivo biocompatibility and degradation behavior of Mg alloy coated by calcium phosphate in a rabbit model

In vivo biocompatibility and degradation behavior of Mg alloy coated by calcium phosphate in a rabbit model

Sirolimus-loaded CaP coating on Co-Cr alloy for drug-eluting stent

Nanotechnology Enabled In situ Sensors for Monitoring Health

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