Calcium Phosphate Glass (CPG): Potential as Biomaterial for Hard-Tissue Repair

Lee, Yong Keun; LeGeros, Racquel Z.

doi:10.4028/www.scientific.net/kem.377.43

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Phosphate based glasses have been widely considered as potential materials for the repair and reconstruction of bone [4][5][6] . Their hydrolytic degradation rate can be varied from hours to months by simply changing the glass composition and the composition can closely match that of the inorganic phase of bone [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles

Zhu

Ahmed

Parsons

et al. 2018

Textile Research Journal

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Phosphate glass fibers have been widely considered as potential biomedical materials for orthopedical application due to their full degradability and excellent cytocompatibility. In this study, phosphate-based glass fibers were drawn from the glass system 48P2O5-12B2O3-14CaO-20MgO-1Na2O-5Fe2O3, via a melt-drawn spinning process and then woven into textile fabric using a small lab-scale inkle-loom. The annealing treatment was applied to both fibers and textiles with 1-hour heat treatment at 540℃, which was 10℃ above the glass transition temperature. An increase in Young's modulus was observed for the single filament fibers and a decrease in tensile strength with annealing treatment. During the degradation period, the tensile strength of non-annealed fibers presented a decrease by day 28, whilst annealed fibers had increased by day 7, then decreased by day 28, which was suggested to be due to the peeling effect observed on the surface of the fibers. The cytocompatibility of the textile fabric with annealing treatment (A-textile) and the non-annealed fabric (N-textile) was characterized via seeding of MG63 cells. Higher metabolic activity and DNA concentration were obtained for the A-textile samples when compared to the N-textile, which was suggested to be due to the lower dissolution rate of the A-textile resulting in fewer ions leaching into the solution. The phosphate glass fiber textiles investigated in this study have shown potential application as bioresorbable composites reinforcement for orthopedic treatment.

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Section: Introductionmentioning

confidence: 99%

The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles

Zhu

Ahmed

Parsons

et al. 2018

Textile Research Journal

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“…29,30 In particular, studies by Lee et al 30 have demonstrated that glasses with a Ca/P molar ratio of 0.6 increased mineralization and alkaline phosphatase activity of MC3T3 cells, a preosteoblast-like cell line. Additionally, the same calcium phosphate glass composition was shown to promote almost complete bony in-growth in critical size calvarial defects in rats by 9 weeks.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28] Previously, we have demonstrated that a novel calcium phosphate glass (CPG), part of the CaO-P 2 O 5 -NaF-MgO-ZnO system, has osteoconductive and resorbable characteristics in vivo. 29,30 In particular, studies by Lee et al 30 have demonstrated that glasses with a Ca/P molar ratio of 0.6 increased mineralization and alkaline phosphatase activity of MC3T3 cells, a preosteoblast-like cell line. Additionally, the same CPG composition was shown to promote almost complete bony in-growth in critical size calvarial defects in rats by 9 weeks.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial property expressed by a novel calcium phosphate glass

et al. 2013

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We have developed a calcium phosphate glass (CPG) doped with Zn2+ or F− or combined Zn2+ and F− ions, which are naturally found in the human body and play a dual role in bone formation and antibacterial activity. Previously, we have demonstrated that this family of CPGs has superior osteoconductive and resorbable properties in vivo. This study aimed to investigate the antibacterial property of CPGs incorporating Zn2+ and/or F−. We used Streptococcus mutans as a model organism because it is one of the major human oral pathogens and an early colonizer, and it has been associated with several oral infections, such as dental caries, periodontitis, and peri-implantitis. 0.01g and 0.05g of CPGs were incubated with Streptococcus mutans for 0, 2, 4, and 6 h. Serial dilutions were plated in triplicate and colony forming units were determined. The antimicrobial effect of CPG incorporating Zn2+ or F− was greater than CPG incorporating both these ions. CPG without doping produced a moderate antimicrobial effect. This family of CPGs, previously shown to promote new bone formation in vivo, is demonstrated to have superior bactericidal properties.

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Structural, thermal, in vitro degradation and cytocompatibility properties of P2O5-B2O3-CaO-MgO-Na2O-Fe2O3 glasses

Zhu

Ahmed

Parsons

et al. 2017

Journal of Non-Crystalline Solids

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Borophosphate glasses with compositions of (48-x)P2O5-(12+x)B2O3-14CaO-20MgO-1Na2O-5Fe2O3 (where x=0, 3, 8 mol%) were prepared via a melt-quenching process. The effects of replacing P2O5 with B2O3 on the structural, thermal, degradation properties and cytocompatibility were investigated. Fourier Transform Infrared (FTIR) spectroscopy analysis confirmed the existence of BO3 triangular units and BO4 tetrahedral units within all the glasses with an increase of B/P ratio from 0.25 to 0.5. The BO4 units within the glass structure were observed to cause an increase in density (ρ) as well as glass transition (Tg) temperature and to decrease the crystallisation temperature (Tc). A decrease in thermal stability which indicated by process window was also observed in the case of substitution of P2O5 with B2O3. Degradation analysis of the glasses indicated that the dissolution rate increased with the addition of B2O3. The decrease in the thermal stability and chemical durability were attributed to the increase of BO3 units, which could increase crystallisation tendency and be easily hydrolysed by solution. The effect of boron addition on the cytocompatibility of the glasses was analysed using Alamar Blue and Alkaline Phosphatase (ALP) assays and DNA quantification. MG63 osteosarcoma cells cultured in direct contact with the glass samples surface for 14 days showed better cytocompatibility, compared to the Tissue Culture Plastic (TCP) control group. In summary, the glass formulation with 12 mol% B2O3 presented the best cytocompatibility and thermal stability, thus could be considered for continuous fibre fabrication in future research and downstream activities.

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Calcium Phosphate Glass (CPG): Potential as Biomaterial for Hard-Tissue Repair

Cited by 5 publications

References 48 publications

The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles

The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles

Antibacterial property expressed by a novel calcium phosphate glass

Structural, thermal, in vitro degradation and cytocompatibility properties of P2O5-B2O3-CaO-MgO-Na2O-Fe2O3 glasses

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