Calcium Phosphates and Nanocrystalline Apatites for Medical Applications

Victor, Sunita Prem; Sharma, Chandra P.

doi:10.1002/9781118482513.ch4

Cited by 2 publications

(1 citation statement)

References 123 publications

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“…Synthetic hydroxyapatite (HA) has been used for a variety of biomedical applications 1 as matrices for controlled drug release, adjuvant to dental implants and bone cements, tooth paste additives, dentrifices, maxillo-facial surgery, pulp-capping materials, coatings on metallic implants such as Ti alloys, CoCrMo alloys or stainless steels etc. Recently, much attention has been focused on photocatalytic activity of HA to decompose odor compounds such as methyl mercaptane 2 and dimethyl sulfide 3 , since HA is very good adsorbent and the surface OH groups adsorb CO 2 , NO x , H 2 O, organic compounds and decompose them effectively under ultraviolet (UV) irradiation.…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic and Antibacterial Activity of Titanium, Fluorine and Silver Co-Substituted Hydroxyapatite

Sandhyarani

Rameshbabu

Venkateswarlu

et al. 2013

Int. J. Mod. Phys. Conf. Ser.

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Synthetic hydroxyapatite (HA), an analogue of the mineral component of bone tissue has been widely used in medicine as bone replacing material. To impart specific properties, HA can be chemically modified by anionic and cationic substitutions during synthesis. Thus the present study was focused in synthesizing nanocrystalline Ti , Ag and F co-substituted HA by microwave synthesis. The prepared powders were characterized by XRD and FTIR for their crystal size, cystallinity and functional groups respectively. XRD spectra reveal that crystal size of prepared powders was in the range of 21–25 nm in as synthesized condition and 45–51 nm in 900 ˚C heat-treated condition. Complete decomposition of HA to tri calcium phosphate was observed for Ti substituted HA powder after heat-treatment. Addition of F improved the thermal stability of Ti substituted HA as indicated by predominant phase of HA after heat-treatment. The photocatalytic activity of co-substituted HA powders was examined by degradation of methylene blue (5 × 10−5 M concentration) under visible light irradiation and the results were compared with pure HA . The degradation efficiency of co-substituted HA with respect to methylene blue was twice as high as that of pure HA. Ti and Ag has improved the visible light photocatalytic activity of HA, further F co-substitution has not affected the photocatalytic activity of substituted HA. The antibacterial effect of prepared powders was observed against 1 × 105 cells/mL of Escherichia coli using spread plate method at 24 h incubation period. Ag co-substituted HA showed complete inhibition of growth of Escherichia coli. Thus, among Ti , Ti-F , Ti-F-Ag substituted HA powders, Ti-F-Ag co-substituted HA with excellent visible light photocatalytic activity and anti-bacterial property is expected to be a potential candidate for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Photocatalytic and Antibacterial Activity of Titanium, Fluorine and Silver Co-Substituted Hydroxyapatite

Sandhyarani

Rameshbabu

Venkateswarlu

et al. 2013

Int. J. Mod. Phys. Conf. Ser.

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3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives

Cheng

et al. 2021

IJN

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Recent developments in three-dimensional (3D) printing technology offer immense potential in fabricating scaffolds and implants for various biomedical applications, especially for bone repair and regeneration. As the availability of autologous bone sources and commercial products is limited and surgical methods do not help in complete regeneration, it is necessary to develop alternative approaches for repairing large segmental bone defects. The 3D printing technology can effectively integrate different types of living cells within a 3D construct made up of conventional micro- or nanoscale biomaterials to create an artificial bone graft capable of regenerating the damaged tissues. This article reviews the developments and applications of 3D printing in bone tissue engineering and highlights the numerous conventional biomaterials and nanomaterials that have been used in the production of 3D-printed scaffolds. A comprehensive overview of the 3D printing methods such as stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), and ink-jet 3D printing, and their technical and clinical applications in bone repair and regeneration has been provided. The review is expected to be useful for readers to gain an insight into the state-of-the-art of 3D printing of bone substitutes and their translational perspectives.

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Calcium Phosphates and Nanocrystalline Apatites for Medical Applications

Cited by 2 publications

References 123 publications

Photocatalytic and Antibacterial Activity of Titanium, Fluorine and Silver Co-Substituted Hydroxyapatite

Photocatalytic and Antibacterial Activity of Titanium, Fluorine and Silver Co-Substituted Hydroxyapatite

3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives

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