1999
DOI: 10.1002/(sici)1099-0496(199902)27:2<95::aid-ppul5>3.3.co;2-x
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Calcium‐PS‐dependent protein kinase C and surfactant protein A in isolated fetal rabbit type II alveolar cells and surfactant‐related material

Abstract: Summary. The fetal lung secretes significant quantities of surfactant during late gestation to prepare for initiation of respiration at birth. However, the mechanism by which this occurs has not been determined. Since Ca 2+ -phosphatidylserine (PS)-dependent protein kinase C has been implicated in surfactant secretion in adult lung, the present study was done to determine whether this enzyme is also involved in the initiation of surfactant release from fetal type II cells. Type II cells isolated from gestation… Show more

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Cited by 3 publications
(4 citation statements)
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“…PKC substrates in this pathway have not been identified. Phorbol ester-induced translocation of PKC to the LBs has been reported (125), suggesting that it might phosphorylate proteins located at or near LBs. One likely candidate may be annexin VII (synexin), which has been implicated in Ca 2ϩ -dependent LB fusion with the plasma membrane (see Ref.…”
Section: Cytoskeleton In Lb Secretion)mentioning
confidence: 99%
“…PKC substrates in this pathway have not been identified. Phorbol ester-induced translocation of PKC to the LBs has been reported (125), suggesting that it might phosphorylate proteins located at or near LBs. One likely candidate may be annexin VII (synexin), which has been implicated in Ca 2ϩ -dependent LB fusion with the plasma membrane (see Ref.…”
Section: Cytoskeleton In Lb Secretion)mentioning
confidence: 99%
“…PKC proteins control many ATII cell functions, including regulation of surfactant phospholipid secretion (29,48), modulation of arachidonic acid metabolism (43), or stimulation of ion transporters (61). Nevertheless, there are no studies linking PKC proteins to ERK activation in ATII cells, although a recent report has described the participation of PKC proteins in ERK activation in A549 cells (34).…”
Section: Discussionmentioning
confidence: 98%
“…In rat type II cells, the phorbol ester TPA activates PKC-␣, -␤I, -␤II, -␦, and -and has been shown to target PKC-to a membrane fraction (14). In fetal rabbit type II cells, TPA causes the translocation of PKC activity to a lamellar body fraction (39). TPA stimulates PKC activity associated with a membrane fraction rather than the cytosolic fraction of lung epithelial cell homogenates (2).…”
Section: Discussionmentioning
confidence: 99%
“…Activation of PKC impairs the barrier function of epithelia and, in the lung, increases endothelial permeability and can lead to pulmonary edema and respiratory distress syndrome (RDS) (5,43). Several studies have documented the involvement of certain PKC isoforms, i.e., PKC-and Ca-/phosphatidylserine (PS)-dependent PKC, in surfactant secretion in primary cultures of alveolar type II cells (14,39).…”
mentioning
confidence: 99%