Calcium Pyrophosphate Dihydrate Crystal Deposition in Gouty Tophi

Ea, Hang‐Korng; Gauffenic, Alan; Nguyen, Quang Dinh; Pham, N.G.; Olivier, O.; Frochot, Vincent; Bazin, Dominique; Le, Nghia Hieu; Marty, Caroline; Ostertag, Agnès; Cohen‐Solal, Martine; Laredo, Jean‐Denis; Richette, Pascal; Bardin, Thomas

doi:10.1002/art.41515

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…Experts favored creating a new item capturing repeatedly negative synovial fluid crystal analysis, distinct from an item characterized by a single negative synovial fluid crystal analysis. Monosodium urate crystals were retained as a potential criterion for 2 reasons: gout and CPPD can co-occur, CPP crystals can be found in gouty tophi, and there is a possibility that monosodium urate crystals could carry negative weight toward classifying a patient as having CPPD (24,25).…”

Section: Resultsmentioning

confidence: 99%

“…CPPD classification criteria are being developed through a 4-phase process. The process began by generating a degli Studi di Torino, Turin, Italy; 16 22 Francisca Sivera, MD, PhD: Hospital General Universitario Elda, Elda, and Universidad Miguel Hernandez, Elche, Spain; 23 Lisa K. Stamp, MD: University of Otago, Christchurch, New Zealand; 24 Robert Terkeltaub, MD: San Diego Veterans Administration Healthcare Service and University of California-San Diego. † Dr. Naden is deceased.…”

Section: Methodsmentioning

confidence: 99%

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Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction

Tedeschi

Pascart

Latourte

et al. 2022

Arthritis Care & Research

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Objective Classification criteria for calcium pyrophosphate deposition (CPPD) disease will facilitate clinical research on this common crystalline arthritis. Our objective was to report on the first 2 phases of a 4‐phase process for developing CPPD classification criteria. Methods CPPD classification criteria development is overseen by a 12‐member steering committee. Item generation (phase I) included a scoping literature review of 5 literature databases and contributions from a 35‐member combined expert committee and 2 patient research partners. Item reduction and refinement (phase II) involved a combined expert committee meeting, discussions among clinical, imaging, and laboratory advisory groups, and an item‐rating exercise to assess the influence of individual items toward classification. The steering committee reviewed the modal rating score for each item (range –3 [strongly pushes away from CPPD] to +3 [strongly pushes toward CPPD]) to determine items to retain for future phases of criteria development. Results Item generation yielded 420 items (312 from the literature, 108 from experts/patients). The advisory groups eliminated items that they agreed were unlikely to distinguish between CPPD and other forms of arthritis, yielding 127 items for the item‐rating exercise. Fifty‐six items, most of which had a modal rating of +/– 2 or 3, were retained for future phases. As numerous imaging items were rated +3, the steering committee recommended focusing on imaging of the knee and wrist and 1 additional affected joint for calcification suggestive of CPP crystal deposition. Conclusion A data‐ and expert‐driven process is underway to develop CPPD classification criteria. Candidate items comprise clinical, imaging, and laboratory features.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction

Tedeschi

Pascart

Latourte

et al. 2022

Arthritis Care & Research

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“…The persistence of tophi even in patients in clinical remission (38.1%) may be related to a "dense" collection of MSU crystals requiring a more aggressive or a more prolonged ULT or to the histological composition of the tophus itself. In fact, some studies have hypothesized that the surrounding fibrotic tissue or peri-tophaceous calcific deposits may persist despite an effective ULT [34,36,37]. Thus, clinical remission can be recorded at 12 months also in patients with imaging evidence of MSU deposits.…”

Section: Discussionmentioning

confidence: 99%

Sonographic estimation of monosodium urate burden predicts the fulfillment of the 2016 remission criteria for gout: a 12-month study

et al. 2021

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Objective To investigate whether baseline monosodium urate (MSU) burden estimated by ultrasound (US) predicts the achievement of the 2016 remission criteria for gout after 12 months. Methods In this 12-month prospective, observational and single-center study, patients with gout fulfilling all the domains of the 2016 preliminary remission criteria for gout at baseline and on urate-lowering therapy (ULT) for at least the preceding 6 months were consecutively enrolled. The US findings indicative of MSU deposits [aggregates, double contour (DC) sign, and/or tophi] were identified according to the Outcome Measure in Rheumatology US Working Group definitions. The US MSU burden was estimated by evaluating elbows, wrists, 2nd metacarpophalangeal joints, knees, ankles, and 1st metatarsophalangeal joints. Results Remission criteria were fulfilled in 21 (42.0%) out of 50 patients at 12 months. The baseline US MSU burden was significantly lower in patients who achieved remission than in those who did not fulfill the remission criteria at 12 months (1.9±1.8 vs 5.1±3.1, p<0.01). US scores and ongoing flare prophylaxis were the only significant predictors of remission with an odds ratio of 10.83 [(95%CI=1.14–102.59), p=0.04] for the absence of MSU deposits, 5.53 [(95%CI=1.34–22.76), p<0.01] for the absence of aggregates, 7.33 [(95%CI=1.71–31.44), p<0.01] for the absence of DC sign, 3.88 [(95%CI=1.08–13.92), p=0.04] for the absence of tophi, and 0.23 [(95%CI=0.07–0.75), p=0.02] for ongoing flare prophylaxis. Conclusion In gout, baseline US estimation of MSU burden is an independent predictor of the achievement of the remission criteria at 12 months.

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“…We have already investigated biological samples from different organs and parts of the human body, namely kidney [177][178][179][180][181][182][183], prostate [184,185], breast [13,103], thyroid [104][105][106], cartilage [186][187][188][189][190][191][192][193], bone [194][195][196][197], tooth [198], pancreas [199], skin and hairs [53][54][55]147,165,168,[200][201][202][203] and cardiovascular system [140,204,205]. We have also investigated cells [206], mice [207][208][209][210], and medical devices [211,212], as well as chemical compounds identified in k...…”

Section: Characterization By Physicochemical Techniquesmentioning

confidence: 99%

Foreword to microcrystalline pathologies: combining clinical activity and fundamental research at the nanoscale

Bazin¹,

Daudon²,

Frochot³

et al. 2022

Comptes Rendus. Chimie

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This contribution underlines the key role of physicochemical characterisation techniques in the area of medical research. The starting point centres on the Mid-InfraRed platform located at the Tenon hospital and dedicated to multidisciplinary functional investigations. In the last two decades, we have enhanced this platform by creating a network combining researchers from varied disciplines such as physicists, chemists, and clinicians. The resultant research dynamism is underscored by metrics such as 71 references in Pubmed and 129 in Web of Science, and the high impact of the journals in which we have published (New England Journal of Medicine, Kidney International, Chemical Review. . . ). It is of paramount importance to disseminate these physicochemical techniques among young doctors, and to establish collaborations with appropriate private companies.

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Calcium Pyrophosphate Dihydrate Crystal Deposition in Gouty Tophi

Cited by 10 publications

References 14 publications

Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction

Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction

Sonographic estimation of monosodium urate burden predicts the fulfillment of the 2016 remission criteria for gout: a 12-month study

Foreword to microcrystalline pathologies: combining clinical activity and fundamental research at the nanoscale

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