Calcium-Regulating Hormones in Essential Hypertension

Resnick, Lawrence M.; Müller, Franco B.; Laragh, John H.

doi:10.7326/0003-4819-105-5-649

Cited by 347 publications

(85 citation statements)

References 25 publications

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“…It was observed that surgically removing hyperactive parathyroids induced decreased blood pressure in SHR (Mann et al 1987, Onsgaard-Meyer et al 1994, Rybczynska et al 2005 as well as in patients with primary hyperparathyroidism (Diamond et al 1986, Resnik et al 1986, Niederle et al 1987. These findings indicated the connection between parathyroid glands and observed hypertension.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive effect of calcilytic NPS 2143 administration in rats

Rybczyńska

Lehmann²,

Jurska-Jasko³

et al. 2006

Journal of Endocrinology

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Secretion of parathormone (PTH), the main parathyroid hormone, which is under the control of the calcium sensing receptor, might be inhibited by calcimimetics and stimulated by calcilytics. Parathyroid glands also secrete parathyroid hypertensive factor. Recently, it was shown that calcimimetic NPS R-568 induced decreased blood pressure in spontaneously hypertensive rats (SHR) in the presence of parathyroid glands. Therefore, the aim of this study was to determine whether administration of the calcilytic NPS 2143 provoked an increase of mean arterial blood pressure (MAP) in normotensive rats. We used male Wistar rats anaesthetized with thiopental. Clearance experiments were performed and the effect of bolus, 1 mg/kg body weight i.v. of NPS 2143 on MAP in the presence and absence of thyroparathyroidectomy (TPTX) was monitored continuously. Calcilytic properties of NPS 2143 were confirmed directly by a significant (P!0$05) increase of plasma PTH concentration, and indirectly by a rise of plasma Ca 2C concentration and urinary fractional phosphate excretion (FE Pi). NPS 2143 administration markedly (P!0$05) increased MAP, calculated as the difference (D) in MAP between sequential measurements and the time of bolus injection of calcilytic. The observed increase of blood pressure in the NPS 2143 group was also significant (P!0$05) compared with the control group. Performance of TPTX prevented the hypertensive effect of NPS 2143. We conclude that NPS 2143 is responsible for increased blood pressure in rats in the presence of parathyroid glands.

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Section: Discussionmentioning

confidence: 99%

Hypertensive effect of calcilytic NPS 2143 administration in rats

Rybczyńska

Lehmann²,

Jurska-Jasko³

et al. 2006

Journal of Endocrinology

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“…Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones in essential hypertension have been described (28,570,571). However, the mechanisms that mediate these responses are unknown.…”

Section: Hypertensionmentioning

confidence: 99%

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials

Wimalawansa¹

1996

Endocrine Reviews

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“…Resnick et al 28 have reported that in humans with low renin essential hypertension, oral administration of NaCl induces increases in blood pressure that are positively correlated with NaCl-induced increases in the plasma concentration of 1,25(OH) 2 D. In 12-week-old SHR in which blood pressure is clearly increased, the decreased levels of 1,25(OH) 2 D may be a consequence of, or a protective response to, established hypertension.…”

Section: Discussionmentioning

confidence: 99%

Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats.

Kurtz¹,

Portale²,

Morris³

1986

Hypertension

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SUMMARY It has been contended that the metabolism of vitamin D in spontaneously hypertensive rats (SHR) is different from that in Wistar-Kyoto rats (WKY). To investigate this possibility, the plasma concentration of 1, 25-dihydroxycholecalciferol (1,25[OH] 2 D) and several known determinants of its production rate were measured in SHR and WKY given normal and restricted amounts of dietary phosphorus. In 12-week-old male SHR given a normal amount of dietary phosphorus, the mean plasma concentration of 1,25(OH) 2 D (72 ± 5 pg/ml) was significantly lower than that in agematched WKY (129 ± 6 pg/ml; p< 0.001). The lower plasma concentration of 1,25(OH) 2 D in the SHR could not be attributed to higher circulating levels of inorganic phosphorus or ionized calcium, lower plasma concentrations of 25-hydroxycholecalciferol, or acidosis. However, in the SHR, urinary excretion of cyclic adenosine 3',5'-monophosphate (12.5 ± 0.4 nmol/mg creatinine) was significantly lower than that in WKY (15.2 ± 0.3 nmol/mg creatinine; p<0.001). In both SHR and WKY, restriction of dietary phosphorus for 1 week induced an increase in the plasma concentration of 1,25(OH) 2 D without affecting blood pressure. The current findings Indicate that in 12-week-old male SHR, 1,25(OH) 2 D metabolism is different from that in age-matched WKY. The activity of 25-hydroxyvitamin D-la-hydroxylase, however, appears to be at least partially responsive to short-term restriction of dietary phosphorus. In SHR, the activity of 25-hydroxyvitamin D-la-hydroxylase may be lower than that hi WKY, perhaps due in part to some impairment in the renal metabolism of, or responsiveness to, cyclic adenosine 3,5'-monophosphate. (Hypertension 8: 1015(Hypertension 8: -1020(Hypertension 8: , 1986 KEY WORDS • 1,25-dihydroxycholecalciferol • hypertension • spontaneously hypertensive rats • phosphorus I N spontaneously hypertensive rats (SHR), the metabolism of calcium is different from that in Wistar-Kyoto rats (WKY), the most commonly used control. In SHR, increased urinary excretion of calcium, decreased serum or blood concentrations of ionized calcium, and increased serum concentrations of parathyroid hormone (PTH) have been reported. '~* In Received February 21, 1986; accepted June 16, 1986. support of their statement that SHR "represent a naturally occurring model of disturbed vitamin D metabolism," Lucas et al. 3 recently reported that in 12-week-old SHR, the mean serum concentration of 1, 25-dihydroxycholecalciferol (1,25[OH] 2 D) was lower than that in age-matched WKY. This difference, however, has not been found by other investigators in 10-to 15-week-old SHR and W K Y .4 6 7 In most of the previous studies in SHR and WKY, major determinants of 1,25(OH) 2 D production were not evaluated systematically in the same animals in which plasma levels of 1,25(OH) 2 D were measured. In the current study, we simultaneously measured plasma levels of 1,25(OH) 2 D and major determinants of 1,25(OH) 2 D production in 12-week-old SHR and WKY. To investigate the responses of SHR an...

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Calcium-Regulating Hormones in Essential Hypertension

Cited by 347 publications

References 25 publications

Hypertensive effect of calcilytic NPS 2143 administration in rats

Hypertensive effect of calcilytic NPS 2143 administration in rats

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials

Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats.

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