Calcium Regulation by EF-hand Protein in the Brain

Leclerc, Estelle; Sturchler, Emmanuel; Heizmann, Claus W.

doi:10.1007/978-0-387-30370-3_27

Cited by 4 publications

(4 citation statements)

References 249 publications

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“…The members of the EF-hand superfamily can be divided into two main categories according to their calcium affinity or their ability to change conformation following Ca 2+ binding (Leclerc et al, 2009). Calmodulins (CaM), the S100 superfamily, and the neuronal calcium sensors such as DREAM constitute the first group of calcium sensors involved in Ca 2+ signaling.…”

Section: Discussionmentioning

confidence: 99%

“…While much is known about how the different Ca 2+ signals are generated during the initial phases of nervous system formation, much less is known about the EF-hand calcium proteins involved in the transmission of these Ca 2+ signals. The members of the EF-hand superfamily can be divided into two main categories according to their calcium affinity or their ability to change conformation following Ca 2+ binding (Leclerc et al, 2009 ). Calmodulins (CaM), the S100 superfamily, and the neuronal calcium sensors such as DREAM constitute the first group of calcium sensors involved in Ca 2+ signaling.…”

Section: Discussionmentioning

confidence: 99%

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The calcium: an early signal that initiates the formation of the nervous system during embryogenesis

Leclerc

Néant

Moreau

2012

Front. Mol. Neurosci.

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The calcium (Ca2+) signaling pathways have crucial roles in development from fertilization through differentiation to organogenesis. In the nervous system, Ca2+ signals are important regulators for various neuronal functions, including formation and maturation of neuronal circuits and long-term memory. However, Ca2+ signals are also involved in the earliest steps of neurogenesis including neural induction, differentiation of neural progenitors into neurons, and the neuro-glial switch. This review examines when and how Ca2+ signals are generated during each of these steps with examples taken from in vivo studies in vertebrate embryos and from in vitro assays using embryonic and neural stem cells (NSCs). During the early phases of neurogenesis few investigations have been performed to study the downstream targets of Ca2+ which posses EF-hand in their structure. This opens an entire field of research. We also discuss the highly specific nature of the Ca2+ signaling pathway and its interaction with the other signaling pathways involved in early neural development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The calcium: an early signal that initiates the formation of the nervous system during embryogenesis

Leclerc

Néant

Moreau

2012

Front. Mol. Neurosci.

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“…These proteins constitute the largest family of calcium binding proteins with more than 3000 related entries in the NCBI Reference Sequences Data Bank (6). EF-hands calcium binding proteins are involved in almost all aspects of the cell function in normal and pathologic conditions (4,7). EF-hand domains were first described in carp parvalbumin (8) and have been recently identified in bacterial and viral proteins (9,10).…”

Section: Modificationsmentioning

confidence: 99%

The importance of Ca2 Zn2 signaling S100 proteins and RAGE in translational medicine

Leclerc¹

2011

Front Biosci

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Section: Introductionmentioning

confidence: 99%

The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine

Leclerc

Heizmann²

2011

Front Biosci

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The Receptor for Advanced Glycation Endproducts (RAGE) is a multiligand receptor involved in a large number of human disorders. Identified first as the receptor for the Advanced Glycation Endproducts (AGEs), RAGE has emerged in recent years as a major receptor for many members of the S100 calcium and zinc binding protein family. The interaction with and the signaling triggered by several S100 proteins such as S100B and S100A12 have been studied in details and have shown concentration and cell type dependent signaling cascades. The S100 protein family consists of more than 20 members which present high amino-acid sequence and structural similarities. These small EF-hand calcium binding proteins interact with a large number of protein targets and are almost all been shown to be involved in cancer. In this review we discuss the recent knowledge about the role of S100 proteins and RAGE in human disorders.

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Calcium Regulation by EF-hand Protein in the Brain

Cited by 4 publications

References 249 publications

The calcium: an early signal that initiates the formation of the nervous system during embryogenesis

The calcium: an early signal that initiates the formation of the nervous system during embryogenesis

The importance of Ca2 Zn2 signaling S100 proteins and RAGE in translational medicine

The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine

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