Calcium-restricted ovariectomized sinclair S-1 minipigs: An animal model of osteopenia and trabecular plate perforation

Mosekilde, Lis; Weisbrode, Steven E.; Safron, J.; Stills, Harold F.; Jankowsky, Maryann L.; Ebert, D.C.; Danielsen, Carl Christian; Søgaard, C.H.; Franks, Alan F.; Stevens, M.L.; Paddock, Carol L.; Boyce, Rogely

doi:10.1016/8756-3282(93)90167-9

Cited by 76 publications

(49 citation statements)

References 13 publications

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“…Recently, it was shown that minipigs are comparable to NHP in immunogenicity testing [158,159] and their liver metabolism is similar to that of humans [160]. Additionally, models of porcine osteoporosis have been developed to expand the usefulness of this species for bone research [161][162][163][164].…”

Section: Pigmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

130

116

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Section: Pigmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

130

116

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“…Findings suggest that the Sinclair Si minipig fed a 0.75% calcium restricted diet may be a good model to study the bone remodelling and perimenopausal bone loss in women when an ovariectomy is performed (Mosekilde et al, 1993a and1993b;Boyce et al, 1995). Lafage et al (1995) have also used minipigs to investigate bone active agents such as sodium fluoride, assessed on bone quality and remodelling.…”

Section: Bonesmentioning

confidence: 99%

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Litten-Brown

Corson

Clarke

2010

Animal

147

136

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The aim of this review article is to provide an overview of the role of pigs as a biomedical model for humans. The usefulness and limitations of porcine models have been discussed in terms of metabolic, cardiovascular, digestive and bone diseases in humans. Domestic pigs and minipigs are the main categories of pigs used as biomedical models. One drawback of minipigs is that they are in short supply and expensive compared with domestic pigs, which in contrast cost more to house, feed and medicate. Different porcine breeds show different responses to the induction of specific diseases. For example, ossabaw minipigs provide a better model than Yucatan for the metabolic syndrome as they exhibit obesity, insulin resistance and hypertension, all of which are absent in the Yucatan. Similar metabolic/physiological differences exist between domestic breeds (e.g. Meishan v. Pietrain). The modern commercial (e.g. Large White) domestic pig has been the preferred model for developmental programming due to the 2-to 3-fold variation in body weight among littermates providing a natural form of foetal growth retardation not observed in ancient (e.g. Meishan) domestic breeds. Pigs have been increasingly used to study chronic ischaemia, therapeutic angiogenesis, hypertrophic cardiomyopathy and abdominal aortic aneurysm as their coronary anatomy and physiology are similar to humans. Type 1 and II diabetes can be induced in swine using dietary regimes and/or administration of streptozotocin. Pigs are a good and extensively used model for specific nutritional studies as their protein and lipid metabolism is comparable with humans, although pigs are not as sensitive to protein restriction as rodents. Neonatal and weanling pigs have been used to examine the pathophysiology and prevention/treatment of microbial-associated diseases and immune system disorders. A porcine model mimicking various degrees of prematurity in infants receiving total parenteral nutrition has been established to investigate gut development, amino acid metabolism and non-alcoholic fatty liver disease. Endoscopic therapeutic methods for upper gastrointestinal tract bleeding are being developed. Bone remodelling cycle in pigs is histologically more similar to humans than that of rats or mice, and is used to examine the relationship between menopause and osteoporosis. Work has also been conducted on dental implants in pigs to consider loading; however with caution as porcine bone remodels slightly faster than human bone. We conclude that pigs are a valuable translational model to bridge the gap between classical rodent models and humans in developing new therapies to aid human health.

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“…In vivo paracrine and autocrine signalling cascades leading to bone formation are complex and rely on strict spatiotemporal interplay between select growth factors. Teasing apart the individual roles that each growth factor plays within bone development and healing systems is of the highest (Aerssens et al, 1998;Kimmel and Jee, 1982;Neyt et al, 1998;Pearce et al, 2007;Skurla and James, 2005) (Aerssens et al, 1998;Mosekilde et al, 1993;Pearce et al, 2007;Thorwarth et al, 2005) Primates (Aerssens et al, 1998;Newman et al, 1995;Pearce et al, 2007;Ravaglioli et al, 1996) (Castaneda et al, 2006;Liebschner, 2004;Pearce et al, 2007) (Aerssens et al, 1998;Gomes and Fernandes, 2010;Liebschner, 2004;O'Loughlin et al, 2008) Table 4. Organic, inorganic and synthetic materials for orthopaedic applications in vivo.…”

Section: Individual Growth Factorsmentioning

confidence: 99%

Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man

Gothard¹,

Smith²,

Kanczler³

et al. 2014

eCM

162

125

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Calcium-restricted ovariectomized sinclair S-1 minipigs: An animal model of osteopenia and trabecular plate perforation

Cited by 76 publications

References 13 publications

The rational use of animal models in the evaluation of novel bone regenerative therapies

The rational use of animal models in the evaluation of novel bone regenerative therapies

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man

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