Calcium Signaling in Glioma Cells: The Role of Nucleotide Receptors

Wypych, Dorota; Pomorski, Paweł

doi:10.1007/978-3-030-30651-9_4

Cited by 8 publications

(8 citation statements)

References 166 publications

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“…Activating the cAMP signaling pathway could inhibit glioma cell invasion as well as proliferation and promote apoptosis [ 30 ]. The calcium signaling pathway was screened as a pathway possibly associated with glioma cell invasion and metastasis [ 31 ]. The Wnt signaling pathway was involved in proliferation, migration, differentiation, and apoptosis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Li et al identified that hsa-miR-92b-5p promotes glioma proliferation by promoting DKK3 and then activating the Wnt/beta-catenin signaling pathway [ 32 ]. Moreover, the downregulation of hsa-miR-10b-5p repressed spread, movement, and invasion of glioma cell by the activation of TGF- β 1 stimulation [ 31 ] or homeobox B3 (HOXB3) expression [ 39 ]. For hsa-miR-221-3p, researchers discovered the overexpression could activate the Akt pathway [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma

Liu

Meng

Fang

et al. 2021

Journal of Healthcare Engineering

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Background. Lower-grade glioma is an intracranial cancer that may develop into glioblastoma with high mortality. The main objective of our study is to develop microRNA for LGG patients which will provide novel prognostic biomarkers along with therapeutic targets. Methods. Clinicopathological data of LGG patients and their RNA expression profile were downloaded through The Cancer Genome Atlas Relevant expression profiles of RNA, and clinicopathological data of the LGG patients had been extracted from the database of “The Cancer Genome Atlas.” Differential expression analysis had been conducted for identification of the differentially expressed microRNAs as well as mRNAs in LGG samples and normal ones. ROC curves and K–M plots were plotted to confirm performance and for predictive accuracy. For the confirmation of microRNAs as an independent prognostic factor, an independent prognosis analysis was conducted. Moreover, target differentially expressed genes of these identified prognostic microRNAs that were extracted and protein-protein interaction networks were developed. Moreover, the biological functions of signature were determined through Genome Ontology analysis, genome pathway analysis, and Kyoto Encyclopedia of Genes. Results. 7-microRNA signature was identified that has the ability of categorization of individuals with LGG into high- and low-risk groups on the basis of significant difference in survival during training and testing cohorts (P < 0.001). The 7-microRNA signature had appeared to be robust in predictive accuracy (all AUC> 0.65). It was also approved with multivariate Cox regression along with some traditional clinical practices that we can use 7-microRNA signature for therapeutic purposes as a self-regulating predictive OS factor (P < 0.001). KEGG and Gene Ontology (GO) analyses reported that 7-microRNAs had mainly developed in important pathways related with glioma, e.g., the “cAMP signaling pathway,” “glutamatergic synapses,” and “calcium signaling pathway”. Conclusion. A newly discovered 7-microRNA signature could be a potential target for the diagnosis and treatment for LGG patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma

Liu

Meng

Fang

et al. 2021

Journal of Healthcare Engineering

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“…-Calcium signaling (hereafter denoted by CAS) is evolutionary the oldest, yet most common way by which a wide diversity of cells communicates to each other [22]. Change in calcium signaling is a major modulator of the glial cell behavior [43]. -PI3K-Akt signaling (hereafter denoted by PA) is pivotal for the growth, metabolism, survival, angiogenesis, autophagy, and chemotherapy resistance of the malignant astrocytic glioma [44].…”

Section: Pathway Analysismentioning

confidence: 99%

Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes

Iacobaş

Stout

et al. 2020

Genes

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We profiled the transcriptomes of primary mouse cortical astrocytes cultured alone or co-cultured with immortalized precursor oligodendrocytes (Oli-neu cells). Filters between the cell types prevented formation of hetero-cellular gap junction channels but allowed for free exchange of the two culture media. We previously reported that major functional pathways in the Oli-neu cells are remodeled by the proximity of non-touching astrocytes and that astrocytes and oligodendrocytes form a panglial transcriptomic syncytium in the brain. Here, we present evidence that the astrocyte transcriptome likewise changes significantly in the proximity of non-touching Oli-neu cells. Our results indicate that the cellular environment strongly modulates the transcriptome of each cell type and that integration in a heterocellular tissue changes not only the expression profile but also the expression control and networking of the genes in each cell phenotype. The significant decrease of the overall transcription control suggests that in the co-culture astrocytes are closer to their normal conditions from the brain. The Oli-neu secretome regulates astrocyte genes known to modulate neuronal synaptic transmission and remodels calcium, chemokine, NOD-like receptor, PI3K-Akt, and thyroid hormone signaling, as well as actin-cytoskeleton, autophagy, cell cycle, and circadian rhythm pathways. Moreover, the co-culture significantly changes the gene hierarchy in the astrocytes.

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“…-Calcium signaling (hereafter denoted by CAS) is evolutionary the oldest, yet most common way by which a wide diversity of cells communicates to each other [19]. Change in calcium signaling is a major modulator of the glia cell behavior [39].…”

Section: Pathway Analysismentioning

confidence: 99%

Oligodendrocytes Remodel the Genomic Fabrics of Functional Pathways in Astrocytes

Iacobaş¹,

Iacobaş²,

Stout³

et al. 2020

Preprint

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We profiled the transcriptomes of primary mouse cortical astrocytes cultured alone or co-cultured with immortalized precursor oligodendrocytes. The experimental set-up (insert systems) prevented formation of gap junction channels but allowed free exchange of the two culture media. The study complements our previously published reports that the genomic fabrics of major functional pathways in oligodendrocytes are substantially remodeled by the proximity of non-touching astrocytes. Here, we present new analysis indicating that the transcriptomic landscape of astrocytes likewise changes significantly in the proximity of non-touching oligodendrocytes. The research was stimulated by the reported transcriptomic similarity between the brains of Cx43KO and Cx32KO mice, both substantially different from that of the Cx36KO mice. Since the three connexins are expressed in different cell types (Cx43 in astrocytes, Cx32 in oligodendrocytes and Cx36 in neurons), altogether these findings support the idea of a “panglial transcriptomic syncytium” in the mouse brain. Going further, our results suggest that integration in a heterocellular tissue modulates not only the expression profile but also the expression control and networking of the genes in each cell phenotype.

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Calcium Signaling in Glioma Cells: The Role of Nucleotide Receptors

Cited by 8 publications

References 166 publications

Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma

Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma

Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes

Oligodendrocytes Remodel the Genomic Fabrics of Functional Pathways in Astrocytes

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