Calcium Signaling in Interstitial Cells: Focus on Telocytes

Radu, Beatrice Mihaela; Banciu, Adela; Banciu, Doina; Mihai, Radu; Crețoiu, Dragoș; Creţoiu, Sanda Maria

doi:10.3390/ijms18020397

Cited by 24 publications

(17 citation statements)

References 156 publications

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“…Although a lot of studies are needed to talk about a certain function of TCs, a possible contribution to the mechanisms of carcinogenesis is not negligible, by the modification of the tumor microenvironment. As our team previously showed, TCs are not pacemakers but modulate the activity of the surrounding cells using calcium signaling [73]. Our results showed that uterine TCs express T-type calcium channels that might play a role in the generation of endogenous bioelectric signals responsible for the regulation of the surrounding cell behavior [74,75].…”

Section: Human Breast Telocytessupporting

confidence: 50%

Alterations in Calcium Signaling Pathways in Breast Cancer

Dumitru¹,

Toader²,

Creţoiu³

et al. 2018

Calcium and Signal Transduction

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Breast cancer is the second most common cancer in women and the fifth cause contributing to death due to the cancer condition. It is essential to deeply understand the complex cellular mechanisms leading to this disease. There are multiple connections between calcium homeostasis alterations and breast cancer in the literature, but no consensus links the mechanism to the disease prognosis. Among the cells contributing to the breast cancer are the breast telocytes, which connect through gap junctions to other cells, including cancer cells and myoepithelial cells. Multiple proteins (i.e., voltage-gated calcium channels, transient receptor potential channels, STIM and Orai proteins, ether à go-go potassium channels, calcium-activated potassium channels, calcium-activated chloride channels, muscarinic acetylcholine receptors, etc.) coupled with calcium signaling pathways undergo functional and/or expression changes associated with breast cancer development and progression, and might represent promising pharmacological targets. Unraveling the mechanisms of altered calcium homeostasis in various breast cells due to the cancer condition might contribute to personalized therapeutic approaches.

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Section: Human Breast Telocytessupporting

confidence: 50%

Alterations in Calcium Signaling Pathways in Breast Cancer

Dumitru¹,

Toader²,

Creţoiu³

et al. 2018

Calcium and Signal Transduction

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“…TCs have been localized in several other organs as well . Several investigations have suggested that TCs and PDGFRα‐positive cells influence the intestinal motility, among many other functions …”

Section: Introductionmentioning

confidence: 99%

“…17 Several investigations have suggested that TCs and PDGFRα-positive cells influence the intestinal motility, among many other functions. 12,[18][19][20][21] Electron microscopic studies showed that both ICCs and fibroblast-like cells were present around the myenteric ganglia of the human small and large intestine. 5,9 Double immunofluorescence, combined with confocal microscopy, proved that CD34immunoreactive, fibroblast-like cells were distinct but closely attached to ICCs both in human and mouse stomach, small intestine and colon.…”

mentioning

confidence: 99%

Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon

Veress

Ohlsson

2020

J Cellular Molecular Medi

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Telocytes (TCs) are recently described interstitial cells, present in almost all human organs. Among many other functions, TCs regulate gastrointestinal motility together with the interstitial cells of Cajal (ICCs). TCs and ICCs have close localization in the human myenteric plexus; however, the exact spatial relationship cannot be clearly examined by previously applied double immunofluorescence/confocal microscopy. Data on TCs and submucosal ganglia and their relationship to intestinal nerves are scarce. The aim of the study was to analyse the spatial relationship among these components in the normal human ileum and colon with double CD34/CD117 and CD34/S100 immunohistochemistry and high‐resolution light microscopy. TCs were found to almost completely encompass both myenteric and submucosal ganglia in ileum and colon. An incomplete monolayer of ICCs was localized between the TCs and the longitudinal muscle cells in ileum, whereas only scattered ICCs were present on both surfaces of the colonic myenteric ganglia. TC‐telopodes were observed within colonic myenteric ganglia. TCs, but no ICCs, were present within and around the interganglionic nerve fascicles, submucosal nerves and mesenterial nerves, but were only observed along small nerves intramuscularly. These anatomic differences probably reflect the various roles of TCs and ICCs in the bowel function.

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“…In mammals, this interaction is responsible for creating a 3D network between clusters of telocytes (Radu et al, ) the same way as has been observed in the interstitial compartment of the fishes. In mammals, such contact may be homocellular (between telocytes) or heterocellular (between a telocyte and other cell types, for example, telocyte‐immune cell interaction, telocyte‐neuron, telocyte‐blood vessels; Radu et al, ). This is another indication that the interstitial cell observed in this study is a telocyte.…”

Section: Discussionmentioning

confidence: 71%

“…A final aspect to be considered is the presence of calcium in these interstitial cells, supposedly the telocytes, in fishes. Radu et al () describe a possible role played by the signaling of calcium in the telocytes in uterine physiology and reproductive system of mammals.…”

Section: Discussionmentioning

confidence: 99%

Presence, localization and morphology of TELOCYTES in developmental gonads of fishes

Mazzoni

Viadanna

Quagio-Grassiotto

2019

Journal of Morphology

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Telocytes are a new defined type of interstitial cells, considered as a stem cell, with very long and thin cytoplasmic extensions. They are present in the vertebrates, and may participate in tissue remodeling. In fish, during gonadal development, the events that culminate with the germinal epithelium formation are well known. However, the interstitial compartment remains poorly explored, although it may have a great contribution to the morpho-functional changes that occur in the gonad. As in other organisms, in fish, the interstitium consists especially of connective tissue elements. However, until now, there are no reports of the presence and the action of the telocytes in the connective tissue of gonads of fish. Thus, this study aimed to detect the presence, localization and morphology of telocytes during the gonadal development of several species of fish. The gonads were analyzed by light microscopy, transmission electron microscopy and immunohistochemistry for localization of CD34, Vimentin, and metalloproteinases. The presence of two proteins characteristics of mesenchymal cell was detected in cells of the gonads of all species. In addition, they presented a typical morphology of telocytes, showing cellular extensions. Gonadal telocytes also presented positive response to metalloproteinases. In mammals, telocytes can undergo de-differentiation contributing to the reorganization of the extracellular matrix. This role may be performed by the metalloproteinases detected here. The detection of Vimentin and CD34in the same cellular type, associated with its morphological characteristics, allows us to conclude that some interstitial cells in Teleostei are considered telocytes, identical to the ones already described in mammals and other vertebrates. K E Y W O R D Sgonadal remodeling, interstitial cell, Teleostei, telocyte

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Calcium Signaling in Interstitial Cells: Focus on Telocytes

Cited by 24 publications

References 156 publications

Alterations in Calcium Signaling Pathways in Breast Cancer

Alterations in Calcium Signaling Pathways in Breast Cancer

Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon

Presence, localization and morphology of TELOCYTES in developmental gonads of fishes

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