2014
DOI: 10.1016/j.ceca.2014.09.001
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Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

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Cited by 186 publications
(185 citation statements)
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References 352 publications
(547 reference statements)
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“…Numerous studies have demonstrated that calcium (Ca 2+ ) plays a pivotal role in insulin secretion from the islets of Langerhans and that altered cellular Ca 2+ homeostasis may be involved in defective insulin release (7)(8)(9)(10)(11). Nevertheless, according to the classical view of the glucose-sensing machinery, insulin secretion largely depends on voltage-activated Ca 2+ influx, whereas the role of intracellular Ca 2+ release in pancreatic β cells in response to glucose has not been fully elucidated (12)(13)(14).…”
Section: Introductionmentioning
confidence: 99%
“…Numerous studies have demonstrated that calcium (Ca 2+ ) plays a pivotal role in insulin secretion from the islets of Langerhans and that altered cellular Ca 2+ homeostasis may be involved in defective insulin release (7)(8)(9)(10)(11). Nevertheless, according to the classical view of the glucose-sensing machinery, insulin secretion largely depends on voltage-activated Ca 2+ influx, whereas the role of intracellular Ca 2+ release in pancreatic β cells in response to glucose has not been fully elucidated (12)(13)(14).…”
Section: Introductionmentioning
confidence: 99%
“…An occasional event following the addition of high glucose to islets (305,506) and dissociated cells (179,221,434) is a transient decrease in [Ca 2ϩ ] c prior to the initiation of oscillations, which has been ascribed to enhanced uptake into the endoplasmic reticulum (ER) (23,121). This indicates that the ⌬G p maintained in low glucose restricts the activity of one or more pathways sequestering cytosolic Ca 2ϩ , such as the plasma membrane and ER Ca 2ϩ -ATPases.…”
Section: Ion Pumpsmentioning
confidence: 99%
“…Ca 2+ -induced Ca 2+ release (CICR) through RyRs may also occur upon large VDCC-mediated Ca 2+ influx. However, this process is still controversial (reviewed in Gilon et al 2014).…”
Section: Soce In Insulin Secretion: From Capacitative Ca 2+ Entry To mentioning
confidence: 99%
“…The sudden rise in intracellular Ca 2+ levels causes exocytosis of insulincontaining vesicles. In addition to K ATP channels and VDCC, a complex interplay between additional ion channels and intracellular Ca 2+ stores produces unique patterns of oscillatory depolarization and [Ca 2+ ] i changes controlling insulin release (Gilon et al 2014).…”
Section: Introductionmentioning
confidence: 99%