Calcium Supplementation Inhibits the Expression of Parathyroid Hypertensive Factor in DOCA-Salt Hypertensive Rats

Lin, Chi-Mo; Saito, Komei; Tsujino, Takeshi; Yokoyama, Mitsuhiro

doi:10.1093/ajh/7.2.201

Cited by 12 publications

(2 citation statements)

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“…Mothers who have had toxaemia or high blood pressure during pregnancy tend to have children who have high blood pressure until adolescence 19. The parathyroid gland25 and parathyroid hypertensive factor26 could be associated with this effect. Lower levels of these factors could reduce peripheral resistance and pulse pressure during fetal life, protecting against a rise in blood pressure later in life.…”

Section: Resultsmentioning

confidence: 99%

Long term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial

Belizán

Villar

Bergel

et al. 1997

BMJ

163

148

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Section: Resultsmentioning

confidence: 99%

Long term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial

Belizán

Villar

Bergel

et al. 1997

BMJ

163

148

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“…It should, however, be borne in mind that a hypertensive substance named parathyroid hypertensive factor (PHF), which is a peptide of parathyroid origin different from PTH, has been isolated in hypertensive rats and in the blood circulation of hypertensive patients. Besides, this vasopressor substance has also calciotropic properties and could also be involved in the increased ABP associated with the hyperparathyroidism caused by dietary calcium deficiency [55, 56, 57, 58, 59, 60, 61, 62, 63]. …”

Section: Introductionmentioning

confidence: 99%

Parathyroid Hormone and Calcitriol in Hypertension Caused by Dietary Calcium Deficiency in Rats

López‐Miranda

Civantos²,

Blasco³

et al. 1998

J Vasc Res

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Hypertension caused by calcium deficiency in the diet has been linked with an increase in parathyroid hormone (PTH) and calcitriol levels. We evaluated arterial blood pressure (ABP), PTH, and calcitriol in normotensive Sprague-Dawley rats (SDR) and in spontaneously hypertensive rats (SHR) fed from weaning on a control diet with a normal calcium content (1%) or a low-calcium diet (0.1%). The calcemia was also measured in the rats by colorimetric methods. The low-calcium diet decreased the calcemia in both strains and brought about an increase in the ABP which was significant in adult SDR and particularly noticeable during the early hypertensive phase in SHR. The rats fed on this diet had higher hormonal plasma levels when compared with the corresponding values in rats fed on the control diet. In particular, the SDR fed on the low-calcium diet showed much higher PTH (122.6 ± 31.0 pg/ml, p ≤ 0.05) and calcitriol (458.0 ± 13.1 pg/ml, p ≤ 0.01) values than the SDR fed on the control diet (PTH 31.7 ± 2.80 pg/ml; calcitriol 292.1 ± 17.5 pg/ml). These endocrine alterations could justify the increase in ABP caused by dietary calcium deficiency in normotensive rats. Nevertheless, the results of this study indicate that the modifications of the ABP caused by the low-calcium diet in SHR could not be correlated with significant increases in these hormones.

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Parathyroid Hormone and Polyhormones: Production and Export

Díaz

Fuleihan

Brown

2000

Comprehensive Physiology

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The sections in this article are: Role of Extracellular Calcium–Sensing and Extracellular Calcium–Regulated Parathyroid Hormone Secretion in Mineral ion Homeostasis The G Protein–Coupled, Extracellular Calcium–Sensing Receptor Structure and Function Inherited Diseases Resulting from Receptor Mutations Mice with Targeted Disruption of the Receptor Are There Additional Receptors or Other Ion‐Sensing Receptors? Anatomy and Physiology of the Parathyroid Cell Morphology Secretory Pathway Physiological Control of Parathyroid Hormone Secretion by Extracellular Calcium and Other Factors Acute Regulation Additional Ionic Agonists Regulating Parathyroid Hormone Secretion via the Extracellular Calcium‐Sensing Receptor Other Ions Modulating Parathyroid Hormone secretion Rapid Actions of Vitamin D on Parathyroid Cells Regulation of Parathyroid Hormone Secretion by Catecholamines and Other Biogenic Amines Regulation of Parathyroid Hormone Secretion by Lipid Metabolites Regulation of Parathyroid Hormone Secretion by Peptides and Peptide Hormones Miscellaneous Factors Regulating Parathyroid Hormone Secretion Mechanisms Underlying the Acute Regulation of Parathyroid Hormone Secretion by Extracellular Calcium Regulation of Intracellular Degradation of Parathyroid Hormone Regulation of Parathyroid Hormone Gene Expression Chromosomal Localization and Organization of the Parathyroid Hormone Gene Effects of Extracellular Calcium Effects of Extracellular Phosphate Effects of Vitamin D Metabolites Parathyroid Hormone Regulation of Gene Expression by Steroids and Other Hormones Regulation of Parathyroid Hormone Gene Expression by Agents that Increase Intracellular Cyclic Adenosine Monophosphate Regulation of Overall Biosynthetic Activity of the Parathyroid Cell Regulation of Parathyroid Cellular Proliferation Effects of Extracellular Calcium Effects of Vitamin D Metabolites Effect of Extracellular Phosphate Effect of Growth Factors Circadian and Pulsatile Control of Parathyroid Hormone Secretion Circadian Variation Pulsatility Alterations in Circadian Rhythm and Pulsatility in Patients with Abnormal Parathyroid Function Secretion of Factors Other Than Parathyroid Hormone: Possible Autocrine/ Paracrine Regulation of Parathyroid Hormone Secretion Evidence for Autocrine Control of Parathyroid Function Secretion of Parathyroid Hormone–Related Protein Secretion of Chromogranin A‐Derived Peptides Secretion of Other Peptides Secretion of Prostaglandins

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Calcium Supplementation Inhibits the Expression of Parathyroid Hypertensive Factor in DOCA-Salt Hypertensive Rats

Cited by 12 publications

References 0 publications

Long term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial

Long term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial

Parathyroid Hormone and Calcitriol in Hypertension Caused by Dietary Calcium Deficiency in Rats

Parathyroid Hormone and Polyhormones: Production and Export

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