Calcium Supplementation Reduces Vertebral Bone Loss in Perimenopausal Women: A Controlled Trial in 248 Women between 46 and 55 Years of Age*

Elders, Petra; Netelenbos, J. C.; Lips, Paul; Ginkel, F.C. van; Khoe, Edwin; Leeuwenkamp, O. R.; Hackeng, W. H. L.; Stelt, P.F. van der

doi:10.1210/jcem-73-3-533

Cited by 195 publications

(61 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In studies which investigated the effects of supplementation on bone turnover, Elders et al [35] reported that bone turnover reduced after 1 year of calcium supplementation, while no changes in markers of bone metabolism have been observed by Rosen et al [36] after 1 year of calcium supplementation in early menopausal women. Supplementation of high soy protein is associated with lower level of bone resorption, but no changes in serum ALP in post-menopausal Japanese women as compared to calcium supplementation which had no influence on bone metabolism [37].…”

Section: Discussionmentioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

View full text Add to dashboard Cite

Open Access Research Articleactivity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. A number of biochemical assays have been described for measuring serum and urinary concentration of markers of bone metabolism [4] that allow a good estimation of bone metabolic processes and have been established as useful parameters in assessing changes in bone turnover. To date, the mechanisms by which combined exercise and dietary intake lead to changes in bone metabolism are not fully understood.Nutritional supplementation is another main factor associated with bone health and development. Aoe et al. [5] reported that as compared to drugs that have a rapid effect, administration of nutrients related to bone metabolism is relatively safe and inexpensive. To date, the effects of different types of supplementation such as calcium, vitamin D, milk, soy and soy protein on bone mass, turnover and mineral density have been reported [6][7][8][9]. One of the nutrients that has long tradition of use within various medical systems and prescribed for variety of uses from ancient time is honey. Ariefdjohan et al. [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al. [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.Tualang honey is a wild, multi floral honey produced by Apis dorsata bees that form hives on the branches of giant trees named Tualang in the Malaysian rainforest, and it has been reported recently that ovariectomized rats that received Tualang honey showed greater improvements in trabecular bone structure than rats receiving calcium [12], implying the beneficial effects of Tualang honey supplementation on bone. Nevertheless to date, administration of Tualang honey in combination with exercise on bone health and antioxidant status in rats has not been investigated, thus the present study was proposed. AbstractPurpose: To investigate the effects of combined jumping exercise and honey supplementation on bone metabolism and antioxidant status in female rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

View full text Add to dashboard Cite

show abstract

“…Factors affect the low blood calcium levels is inadequate vitamin D, low calcium intake or things that interfere with the absorption of calcium. The reason for calcium disabsorption may be due to the nutrients such as wheat in the form of bread, the a Refrence values in non pregnant women [10] staple cereal that is used daily by Iranian, which can impair intestinal calcium absorption, because of the presence of high amounts of phytic acid in wheat flour [30]. Vitamin D is essential for the maintenance of calcium homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Tabrizi

Pakdel

2013

Ind J Clin Biochem

View full text Add to dashboard Cite

Concentrations of various trace elements are altered during pregnancy with changes in the mother's physiology and the requirements of growing fetus. The aim of the present longitudinal study was to learn the changes of micronutrients Iron (Fe), Calcium (Ca), zinc (Zn) Magnesium (Mg) and copper (Cu) of pregnant woman and their relations with newborns levels. Serum levels of iron, calcium, zinc, magnesium and copper of 162 pregnant women and their newborns were determined by an inductively couple plasma mass spectrometer (ICP/MS). The results showed that majority (41 %) of pregnant women were in age group 26-36 years 55 % had high school and diploma levels of education and the total income ranged between 3 and 5 Rials million per month There was significant difference in iron levels during first, second and third trimesters, 76.0 ± 17.8, 63.5 ± 15.2 and 70.1 ± 14.4 lg/dl respectively. Significant difference was shown in zinc levels 79.5 ± 15, 74.5 ± 16.1, and 65.3 ± 14.9 lg/dl during three trimesters. Copper levels during pregnancy were significantly different (130.9 ± 43.5, 172.0 ± 38.94, 193.2 ± 28.5 lg/dl. The serum levels of calcium and magnesium during pregnancy were constant (Ca: 8.96 ± 0.48, 8.86 ± 0.47, 8.91 ± 0.42 mg/dl and Mg: 2.10 ± 0.21, 2.08 ± 0.28, 2.09 ± 0.29 mg/dl). Results showed that 13 % of pregnant women had hypocalcaemia and hypomagnesaemia. Thirty eight percent and 42 % of pregnant women had iron and zinc deficiency respectively. In this study, unlike zinc, no pregnant women were found deficient in serum copper levels. Calcium, iron, zinc, copper and magnesium levels in the newborn's cord blood were 8.93 ± 0.43, 106.0 ± 26.1, 85.35 ± 16.6, 57.04 ± 13.8 and 1.99 ± 0.27 mg/dl respectively. In the present study the levels of iron and zinc in cord blood were higher than the levels of iron and zinc in maternal serum. The mean level of copper in cord blood serum in the current study was lower than maternal values. The mean serum calcium and magnesium in the serum cord blood and in the serum of the pregnant women were similar.

show abstract

“…Increased habitual calcium intake has been shown to lower bone turnover markers [16]. Although the beneficial effect of calcium supplementation is most marked in the first year of treatment, a slower, more cumulative effect is thought to occur in cortical bone [17,18].…”

Section: Discussionmentioning

confidence: 99%

Annual Feedback Is an Effective Tool for a Sustained Increase in Calcium Intake among Older Women

et al. 2010

View full text Add to dashboard Cite

Abstract:We aimed to optimize calcium intake among the 2,000+ older women taking part in the Vital D study. Calcium supplementation was not included in the study protocol. Our hypothesis was that annual feedback of calcium intake and informing women of strategies to improve calcium intake can lead to a sustained increase in the proportion of women who consume adequate levels of the mineral. Calcium intake was assessed on an annual basis using a validated short food frequency questionnaire (FFQ). Supplemental calcium intake was added to the dietary estimate. Participants and their nominated doctor were sent a letter that the participant's estimated daily calcium intake was adequate or inadequate based on a cutoff threshold of 800 mg/day. General brief statements outlining the importance of an adequate calcium intake and bone health were included in all letters. At baseline, the median daily consumption of calcium was 980 mg/day and 67 percent of 1,951 participants had calcium intake of at least 800 mg per day. Of the 644 older women advised of an inadequate calcium intake at baseline (<800 mg/day), 386 (60%) had increased their intake by at least 100 mg/day when re-assessed twelve months later. This desirable change was sustained at 24 months after baseline with almost half of these women (303/644) consuming over 800 mg calcium per day. This study devised an efficient method to provide feedback on calcium intake to over 2,000 older women. The improvements were modest but significant and most apparent in those with a low intake at baseline. The decreased proportion of these women with an inadequate intake of calcium 12-and 24-months later, suggests this might be a practical, low cost strategy to maintain an adequate calcium intake among older women.

show abstract

Calcium Supplementation Reduces Vertebral Bone Loss in Perimenopausal Women: A Controlled Trial in 248 Women between 46 and 55 Years of Age*

Cited by 195 publications

References 19 publications

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Annual Feedback Is an Effective Tool for a Sustained Increase in Calcium Intake among Older Women

Contact Info

Product

Resources

About