Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

Bär, A.

doi:10.1016/j.cbpa.2008.11.020

Cited by 141 publications

(124 citation statements)

References 312 publications

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“…The consistent finding of lead in the shell regardless of the amount of lead in the edible portion is intriguing and points to a continuous pathway for lead excretion in the chicken. Shell calcification utilizes Ca 2+ from intestinal, dietary absorption as well as from mobilization of bone Ca 2+ reserves [21]. In chickens exposed to lead, the divalent lead cation (Pb 2+ ) may utilize the pathway of calcium deposition in the egg shell.…”

Section: Discussionmentioning

confidence: 99%

Lead Exposure from Backyard Chicken Eggs: A Public Health Risk?

2014

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Section: Discussionmentioning

confidence: 99%

Lead Exposure from Backyard Chicken Eggs: A Public Health Risk?

2014

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“…We focused on investigating TRPV6 and CaBP-D28K, instead of TRPV5 and CaBP-D9K respectively, because the former have been previously identified in the reproductive system, 100 90 80 70 60 50 40 30 20 10 0 Non affected Mean pixel intensity Affected 100 90 80 70 60 50 40 30 20 10 0 Non affected Mean pixel intensity Affected 100 90 80 70 60 50 40 30 20 10 including bird tissues (den Dekker et al 2003, Jelinsky et al 2007, Bar 2008). In addition, CaBP-D9K has not been detected in bird tissues (Bar 2008(Bar , 2009.…”

Section: Introductionmentioning

confidence: 94%

“…The transepithelial calcium reabsorption depends on proteins that mediate the apical calcium entry within the cell, named TRPV5 and TRPV6 (transient receptor potential vanilloid channel), the diffusion of the ion throughout the cytoplasm bound to calcium-binding proteins (CaBP), such as CaBP-D9K or CaBP-D28K, and its extrusion to the extracellular environment in the basolateral membranes of the cells by the Na C /Ca 2C exchanger (NCX) or the plasma membrane calmodulin-dependent calcium ATPase (PMCA; Bindels et al 1991, Van Baal et al 1996, Hoenderop et al 2002, 2005, Bar 2009). This process is orchestrated by several hormones that regulate the expression and activity of the aforementioned proteins, including vitamin D3, androgens, and estrogens (Cai et al 1993, Hoenderop et al 2001, 2005, Van Abel et al 2002, Dick et al 2003, Meyer et al 2007, Oz et al 2007, Suzuki et al 2008, Hsu et al 2010, Yang et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Involvement of the transepithelial calcium transport disruption and the formation of epididymal stones in roosters

Oliveira¹,

Aquino²,

Mahecha³

et al. 2012

Reproduction

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Epididymal lithiasis is a dysfunction of unknown origin characterized by the formation of calcium stones into the lumen of efferent ductules of roosters. Affected animals present an imbalance in the hormonal responsive systems that regulate the expression of proteins involved in the transepithelial calcium transport, as TRPV6, CaBP-D28K, NCX1, and PMCA. Because the efferent ductules are the major site of fluid and calcium reabsorption in excurrent ducts, it was hypothesized that impairment in local calcium homeostasis would lead to lithiasis. To test this hypothesis, we addressed the expression of these proteins in the epididymal region of affected animals. The present study focused on the investigation of the occurrence, tissue distribution, and physiological impact of the transepithelial calcium transport in roosters under normal and pathological conditions. The results showed that affected roosters presented a significant increase in TRPV6 and CaBP-D28k levels, whereas NCX1 and PMCA were not changed. Such alterations were more conspicuous in the proximal efferent ductules, in which was also observed accumulation of calcium within the epithelial cells. These findings provided the first evidences for the involvement of alteration in the expression of proteins essential for calcium reabsorption as a plausible mechanism for the formation of calcium stones within efferent ductules.

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“…On the other hand, they did not observe any effect of phytase or the NPP × phytase interaction on calcium availability. Anyway, the calcium absorption and consequently both retention and ileal digestibility are affected by eggshell formation (Bar 2009). To obtain digesta, it is necessary to slaughter the hens, but it is impossible to do it in one time, in the same stage of shell formation.…”

Section: Discussionmentioning

confidence: 99%

Effect of suboptimal levels of non-phytate phosphorus and exogenous phytase on precaecal digestibility of phosphorus and calcium in laying hens

Musilová¹,

Lichovnikova²,

Kupcikova³

et al. 2017

CZECH J ANIM SCI

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Musilova A., Lichovnikova M., Kupcikova L., Anderle V. (2017): Effect of suboptimal levels of non-phytate phosphorus and exogenous phytase on precaecal digestibility of phosphorus and calcium in laying hens. Czech J. Anim. Sci., 62, 473-481.The precaecal digestibility of phosphorus and calcium in laying hens was evaluated at two dietary levels of non-phytate phosphorus (NPP; 1.58 and 2.03 g/kg) and two levels of exogenous 3-phytase (F; 0 and 300 phytase units (FTU)/kg). A total of 192 ISA Brown hens were used for the study, and were housed in enriched cages (8 per cage). At the end of the experiment, which was the peak of the egg production, the content of the posterior half of the ileum from each hen was collected. The lower level of NPP significantly (P < 0.05) improved the precaecal phosphorus digestibility coefficient. There was no significant difference in the amount of absorbed phosphorus between the lower and the higher level of NPP. The level of NPP with supplementation of exogenous phytase had a significant effect (P < 0.001) on the concentration of phosphorus in ileum, while the higher level of NPP increased phosphorus concentration in the ileum and phytase decreased phosphorus content in the ileal digesta. The phytase had no significant effect on phosphorus precaecal digestibility. There was no significant effect of the both factors, level of NPP, and exogenous phytase on the daily calcium intake, the amount of absorbed calcium, the content of calcium in ileal digesta, and on the precaecal digestibility of calcium. However a significant effect (P < 0.05) of the interaction between NPP and phytase was observed on the amount of absorbed calcium and on the precaecal digestibility coefficient. It can be concluded that the estimation of phosphorus ileal digestibility depends on the level of dietary phosphorus.

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Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

Cited by 141 publications

References 312 publications

Lead Exposure from Backyard Chicken Eggs: A Public Health Risk?

Lead Exposure from Backyard Chicken Eggs: A Public Health Risk?

Involvement of the transepithelial calcium transport disruption and the formation of epididymal stones in roosters

Effect of suboptimal levels of non-phytate phosphorus and exogenous phytase on precaecal digestibility of phosphorus and calcium in laying hens

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