Calcium uptake in skeletal muscle mitochondria

Tate, Charlotte A.; Bonner, Hugh W.; Leslie, Steven W.

doi:10.1007/bf00421715

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…Z-Band and focal streaming were reported in this study, most commonly in fibres with few mitochondria. It is not clear whether the reduced Ca++ uptake reported for endurance activities lasting between 10 and 15 minutes (Tate et al 1978) is also evident in sprint activity. Holloszy (1967) argued that increased oxidative capacity of skeletal muscle from training was linked to an increase in the number of mitochondria, an increase in the size of the mitochondria or a change in composition of the mitochondria.…”

Section: Acute Response To Sprint Exercisementioning

confidence: 89%

“…The accumulation ofMg++ in exhaustive activity may diminish the negative effects of excessive Ca++ uptake. Ca++ uptake may also be dependent on the absolute amount of work completed, as hamsters swum to exhaustion did not present any changes in mitochondrial uptake (Tate et al 1978). Furthermore, exhaustive running for less than 15 minutes reduced mitochondrial Ca++ uptake (Boner et al 1976), suggesting that Ca++ uptake by the mitochondria may be a function of time.…”

Section: Acute Response To Endurance Exercisementioning

confidence: 96%

“…During exhaustive exercise lasting in excess of I hour there is an increase in the uptake of Ca++ into mitochondria which may act to buffer cytoplasmic Ca++ (Tate et al 1978). However, beyond a certain level, the uptake of Ca++ would inhibit ATP production (Tate et al 1978).…”

Section: Acute Response To Endurance Exercisementioning

confidence: 98%

“…However, beyond a certain level, the uptake of Ca++ would inhibit ATP production (Tate et al 1978). The accumulation ofMg++ in exhaustive activity may diminish the negative effects of excessive Ca++ uptake.…”

Section: Acute Response To Endurance Exercisementioning

confidence: 99%

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Acute and Chronic Responses of Skeletal Muscle to Endurance and Sprint Exercise

1990

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Skeletal muscle adapts to the stress of endurance and sprint exercise and training. There are 2 main types of skeletal muscle fibre--slow twitch (ST) and fast twitch (FTa, FTb, FTc). Exercise may produce transitions between FT and ST fibres. Sprint training has decreased the proportion of ST fibres and significantly increased the proportion of FTa fibres, while endurance training may convert FTb to FTa fibres, and increase the proportion of ST fibres (i.e. FTb----FTa----FTc----ST). However, the high proportion of ST fibres documented for elite endurance athletes may be simply the result of natural selection. ST fibres function predominantly during submaximal exercise, whereas FT fibres are recruited as exercise intensity approaches VO2max and/or glycogen stores are depleted. Long distance runners have greater ST and FT fibre areas than untrained controls. However, doubt remains as to whether the ST or FT fibre area is greatest in endurance athletes. Increases in FT fibre area seem to occur during the first 2 months of training whereas ST fibre areas appear to increase after 2 to 6 months of training. Sprint training leads to the preferential use of FT fibres and male, but not female sprinters have larger FT fibres than untrained controls. Mitochondrial proteins and oxidative enzymes, as opposed to VO2max, are important determinants of the duration of endurance exercise. Endurance training increases intramuscular glycogen stores in both FT and ST fibres and produces a 'glycogen-sparing' effect which is characterised by an increased free fatty acid (FFA) metabolism. The activity of glycogen synthase is also increased by endurance training. Sprint training increases glycogen concentrations similarly in all fibre types, reduces the rate of glycogen utilisation at submaximal workloads and allows supramaximal workloads to be maintained for longer periods of time. During endurance exercise the pattern of glycogen depletion varies between muscle fibre types and between muscle groups. Glycogen stores in ST fibres are utilised initially, followed by stores in FTa then FTb fibres. Sprint activities are associated with a much greater rate of glycogen depletion. However, it is unlikely that glycogen depletion causes fatigue during sprinting. Sprint work is associated with a preferential depletion of glycogen from FTb then FTa and ST fibres. Endurance training appears to increase triglyceride stores adjacent to mitochondria and ST fibres have greater triglyceride stores than FT fibres. Endurance exercise is associated with a preferential use of triglycerides from ST fibres and endogenous triglycerides may account for over 50% of the total lipid oxidised during exercise.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Acute Response To Sprint Exercisementioning

confidence: 89%

Section: Acute Response To Endurance Exercisementioning

confidence: 96%

Section: Acute Response To Endurance Exercisementioning

confidence: 98%

Section: Acute Response To Endurance Exercisementioning

confidence: 99%

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Acute and Chronic Responses of Skeletal Muscle to Endurance and Sprint Exercise

1990

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“…We wish to point out, however, an important suggestion made by Siess & Wieland (1980) that the isolation procedure may damage mitochondria from control rats, but not those from hormone-treated rats, which may be protected in some manner. Thus, the optimal conditions for isolating mitochondria may differ after exercise, a point previously made by us (Tate et al, 1978) and by Gale (1974). Although this postulate may be valid, it is clear that the function of hepatic mitochondria in vitro is changed by endurance-type exercise and that this response is stressspecific.…”

Section: Blood Glucosementioning

confidence: 91%

Exercise-Induced Alterations of Hepatic Mitochondrial Function

Tate

Scott

Wolkowicz

et al. 1981

Medicine & Science in Sports & Exercise

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Calcium uptake in skeletal muscle mitochondria

Tate

Bonner

Leslie

1978

Europ. J. Appl. Physiol.

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In order to ascertain the effects of long-term exercise training and long-term exhaustive exercise on mitochondrial 45Ca2+ uptake and related variables in rat skeletal muscle, female rats were randomly divided into three groups: sedentary-rested (SR), trained-rested (TR), and trained-exhausted (TE). The trained groups were exercised five times per week on a treadmill for 22 weeks. At the conclusion of the training period, the TE group was exercised to exhaustion following their daily 1 h run. The 45Ca2+ uptake and endogenous mitochodrial Ca2+ content of skeletal muscle followed stepwise increases of approximately 25% and 50%, respectively, across the groups, suggesting that long-term exercise induces the mitochondria to play an important role as a Ca2+ uptake buffer. A 75--83% reduction in 45Ca2+ binding in the TE group suggests a selective loss and partial saturation of membrane phospholipids with exhaustive exercise. The TE group had a two-fold greater content of mitochondrial Mg2+ than did the rested groups. It is speculated that the mitochondria accumulate Mg2+ during acute exercise to maintain the functional integrity of the membrane, thus offsetting the deleterious effects of excessive Ca2+ uptake

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Calcium uptake in skeletal muscle mitochondria

Cited by 11 publications

References 17 publications

Acute and Chronic Responses of Skeletal Muscle to Endurance and Sprint Exercise

Acute and Chronic Responses of Skeletal Muscle to Endurance and Sprint Exercise

Exercise-Induced Alterations of Hepatic Mitochondrial Function

Calcium uptake in skeletal muscle mitochondria

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