In nuclear medicine, radiopharmaceuticals are used for diagnosis or treatment purposes. Radiopharmaceuticals containing radionuclide in their structure are produced by reactors, generators or cyclotrons and are generally used for scintigraphy or tomographic investigations. The produced radionuclides can be given to the human body together with organic or inorganic substances. In this study, the production reaction cross sections were calculated for two selected radiopharmaceutical nuclei (99 Tc and 115 In) using the semiempirical cross section formula for the (n,) reactions developed by Tel et al. (2008). The density depending on (n, α) reaction cross sections were also investigated with the four Skyrme Hartree Fock parameters (S3, T3, SKM and SKM*). While the calculated value from the semiempirical formula developed by Tel et al. (2008) gave reasonable results, the densitydependent calculations were observed lower values than that of experimental values.