Calculation of survival probabilities for cells exposed to high ion fluences

Surdutovich, Eugene; Solov’yov, Andrey V.

doi:10.1140/epjd/e2018-90022-2

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…These doses are not that high, meaning that the heavy ion fluxes are small enough for the ionic pathways to not overlap. 53 Since the radiation dose is proportional to the flux and LET of the irradiated ions, the distance between ionic pathways can be calculated by knowing the dose and LET in any particular problem. 53 Since carbon ions are high-LET beams, they are selected as radiation particles in this study.…”

Section: Resultsmentioning

confidence: 99%

“…53 Since the radiation dose is proportional to the flux and LET of the irradiated ions, the distance between ionic pathways can be calculated by knowing the dose and LET in any particular problem. 53 Since carbon ions are high-LET beams, they are selected as radiation particles in this study. A total of 24 carbon ion beams with energies ranging from E = 132 MeV/u to E =207 MeV/u were tracked along the main axis of the tumour using the Geant4 simulation code.…”

Section: Resultsmentioning

confidence: 99%

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Optimization of treatment planning for hypoxic tumours and re-modulation of radiation intensity in heavy-ion radiotherapy

Rezaee

2020

Reports of Practical Oncology & Radiotherapy

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Aim: The purpose of this study is to optimize treatment planning in carbon ion radiotherapy, taking into account the effect of tumour hypoxia. Background: In conventional hadron therapy, the goal is to create a homogenous dose in the tumour area and, thus, achieve a uniform cell survival level. Since the induction of a specific damage to cells is directly influenced by the level of hypoxia in the tissue, the varying oxygen pressure in the different regions of hypoxic tumours would disrupt the uniformity of the cell survival level. Materials and methods: Using the Geant4 Monte Carlo Code, the physical dose profile and dose-averaged linear energy transfer were calculated in the tumour. Then, the oxygen enhancement ratio in different areas of the tumour were compared with different pressures. Results: Modulations of radiation intensities as well as energies of ion beams were calculated, both considering and disregarding the effect of hypoxia, and the required dose profiles were compared with each other. Cell survival levels were also compared between the two methods. An equation was obtained for re-modulating the beams in the presence of hypoxia, and radiation weighting factors were extracted for the beam intensities. Conclusion:The results show that taking the effect of hypoxia into account would cause the reduction of average doses delivered to the tumour tissues up to 1.54 times. In this regard, the required dose is reduced by 1.63 times in the healthy tissues before the tumour. This will result in an effective protection of healthy tissues around the tumour.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Optimization of treatment planning for hypoxic tumours and re-modulation of radiation intensity in heavy-ion radiotherapy

Rezaee

2020

Reports of Practical Oncology & Radiotherapy

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“…On the other side, when N ion is very large, ion tracks are likely to overlap. This corresponds to the case of large ion fluences, which was discussed in Surdutovich and Solov'yov (2018). This limit may be important in the case of applications of laser-driven proton beams.…”

Section: Calculation Of Lesion Yields and Survival Curvesmentioning

confidence: 96%

Multiscale modeling for cancer radiotherapies

Surdutovich¹,

Solov’yov²

2019

Cancer Nano

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Background: multiscale scenario of radiation damage with ions It has been 10 years since the first paper on the Multiscale approach (MSA) to ion-beam therapy (Solov'yov et al. 2009) has been published. That paper has manifested the start of the development of a phenomenon-based approach to the assessment of radiation damage with ions, fundamentally different from other methods. The first goal was to understand the scenario of radiation damage with ions in the language of physical, chemical, and biological effects, that is, to relate initial physical effects of energy loss by projectiles

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“…In reference [36] a methodology for calculation of survival curves with an account for ion tracks' interference was developed using the multiscale approach to the physics of radiation damage with ions [52]. The method was applied to cells for which shouldered survival curves have been obtained experimentally.…”

Section: Molecular-level Mechanisms Of Radiation Induced Biodamagementioning

confidence: 99%

Topical Issue on atomic cluster collisions

et al. 2019

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The rapidly emerging field of atomic cluster collisions attracts strong research interest of many experimental and theoretical groups worldwide. Being a highly interdisciplinary field, it has numerous links with atomic, molecular and optical physics, astrophysics, plasma physics, biophysics, physical chemistry, solid state physics and even molecular biology. This Topical Issue presents a state-of-the-art description of current research activities in the field of atomic cluster collisions and atomic cluster science. The contributions to this Issue represent experimental, theoretical and computational studies both at the fundamental level of elementary mechanisms and at a more applied level which is necessary in numerous applications of nano-and biotechnology, materials science and medicine.

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Calculation of survival probabilities for cells exposed to high ion fluences

Cited by 7 publications

References 27 publications

Optimization of treatment planning for hypoxic tumours and re-modulation of radiation intensity in heavy-ion radiotherapy

Optimization of treatment planning for hypoxic tumours and re-modulation of radiation intensity in heavy-ion radiotherapy

Multiscale modeling for cancer radiotherapies

Topical Issue on atomic cluster collisions

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