This paper reports on the use of computational fluid dynamic (CFD) simulations to predict the interruption behaviour of high-voltage circuit breakers (HV-CB) using the self-blast principle. Two different levels of accuracy of the arc model are proven to be sufficiently accurate for simulating the high-current phase and the period around current zero (CZ). For the high-current phase, a simplified equivalent model of the arc is implemented to predict the pressure build-up, and even more important to accurately trace the hot gas from the arcing zone into the exhausts and the heating volume. A detailed analysis of the gas mixing in the heating volume for different arcing times and current amplitudes showed the optimum geometrical design of the heating volume. For the CZ phase, a more detailed arc model is needed including the effects of ohmic heating, radiative energy transfer, and turbulent cooling fully resolved in space and time. The validation with experiments was done and shows good agreement which justifies the use of the implemented model. With it, scaling laws varying only one parameter at a time (pressure and applied current slope) were derived and confirm previously found empirical laws. This is of particular interest, as it is very difficult to derive such scaling laws from experiments where the scatter is always very large and where it is impossible to vary only one parameter at a time. The influence of the most important geometrical parameters of the nozzle on the interruption performance is shown. In addition to previous experimental indications of this, the simulation reveals that turbulent cooling on the arc edge is the main reason for the difference in interruption performance. Moreover, the exact spatio-temporal build-up of arc resistance and with it the detailed understanding of the arc interruption process is possible and shown here for the first time. These simulations enable us to predict HV-CB performance and to minimise the number of development tests and are routinely used in new development projects.