Cálculos biliares asociados al uso de ceftriaxona en niños

Rangel, Daniel A.; Orejarena, A.P. Pinilla; Diaz, M. Bustacara; García, L. H.; Cadena, A. López; Camargo, R. Montoya; Moreno, Luís A.

doi:10.1016/j.anpedi.2013.04.001

Cited by 11 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This requires both a hydrophobic and an anionic group, is expressed specifically in the kidney, and exportsketoglutarate in the opposite direction. In contrast, the anionic transport system for uptake into the tubular cell is more active, resulting in active accumulation [17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation Effects of Cefepime and Ceftriaxone on Renal Function Tests in Albino Male Rats

Jasim,

Ouda,

Umran

2024

UPJOZ

View full text Add to dashboard Cite

Background: The most commonly used antibiotics frequently mentioned in clinical reports of drug-induced nephrotoxicity. The study is designed to investigate the in vivo effect of cefepime and ceftriaxone on functions of kidney in wistar albino rats. Materials and Methods: In this study, 18 male adult Wister albino rats were used. The animals were separated into three groups of six rats each. The rats in the first group were only given normal saline and served as the normal control group. While the rats in the other two groups were given cefepime at a dose of 90 mg/kg/day I.M. and ceftriaxone at a dose of 90 mg/kg/day I.M., respectively, and were treated as follows (for 10 days). Results: By the end of the treatment period, urine was collected by metabolic cage for total protein, pH, and specific gravity measurements. Renal function parameters were measured using blood samples. Both kidneys were removed for histopathological examination after the animals were sacrificed. The data showed no significant differences in (creatinine, BUN, uric acid, and total protein levels) between the normal, cefepime, and ceftriaxone groups, nor in urine analysis data. Histopathological images revealed an important feature of injurious lesions that are more prominent with cefepime, as well as mild inflammation to acute interstitial nephritis in ceftriaxone specimens. Conclusions: It can be concluded that cefepime has a more negative effect on renal function than ceftriaxone and that it should be used in critically ill patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation Effects of Cefepime and Ceftriaxone on Renal Function Tests in Albino Male Rats

Jasim,

Ouda,

Umran

2024

UPJOZ

View full text Add to dashboard Cite

show abstract

Etiology-Based Decision-Making Protocol for Pediatric Cholelithiasis

et al. 2021

View full text Add to dashboard Cite

Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment

Daudon

Frochot

Bazin

et al. 2017

Drugs

130

136

View full text Add to dashboard Cite

Drug-induced calculi represent 1-2% of all renal calculi. The drugs reported to produce calculi may be divided into two groups. The first one includes poorly soluble drugs with high urine excretion that favour crystallisation in the urine. Among them, drugs used for the treatment of patients with human immunodeficiency, namely atazanavir and other protease inhibitors, and sulphadiazine used for the treatment of cerebral toxoplasmosis, are the most frequent causes. Besides these drugs, about 20 other molecules may induce nephrolithiasis, such as ceftriaxone or ephedrine-containing preparations in subjects receiving high doses or long-term treatment. Calculi analysis by physical methods including infrared spectroscopy or X-ray diffraction is needed to demonstrate the presence of the drug or its metabolites within the calculi. Some drugs may also provoke heavy intra-tubular crystal precipitation causing acute renal failure. Here, the identification of crystalluria or crystals within the kidney tissue in the case of renal biopsy is of major diagnostic value. The second group includes drugs that provoke the formation of urinary calculi as a consequence of their metabolic effects on urinary pH and/or the excretion of calcium, phosphate, oxalate, citrate, uric acid or other purines. Among such metabolically induced calculi are those formed in patients taking uncontrolled calcium/vitamin D supplements, or being treated with carbonic anhydrase inhibitors such as acetazolamide or topiramate. Here, diagnosis relies on a careful clinical inquiry to differentiate between common calculi and metabolically induced calculi, of which the incidence is probably underestimated. Specific patient-dependent risk factors also exist in relation to urine pH, volume of diuresis and other factors, thus providing a basis for preventive or curative measures against stone formation.

show abstract

Cálculos biliares asociados al uso de ceftriaxona en niños

Cited by 11 publications

References 17 publications

Evaluation Effects of Cefepime and Ceftriaxone on Renal Function Tests in Albino Male Rats

Evaluation Effects of Cefepime and Ceftriaxone on Renal Function Tests in Albino Male Rats

Etiology-Based Decision-Making Protocol for Pediatric Cholelithiasis

Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment

Contact Info

Product

Resources

About